Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"flavoenzymes"”.
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STRUCTURE-FUNCTION STUDIES OF NOVEL MEDICALLY RELEVANT FLAVOENZYMES
… characterization of two medically-relevant flavoenzymes will be discussed. In a last section we will address a combined computational and experimental study on flavocytochrome b2, a well-characterised flavoenzyme, whose catalytic mechanism is stillat the center of a lively debate. …
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Flavin-dependent Enzymes in Natural Product Biosynthesis
… Because of their chemical versatility, flavoenzymes are commonly involved in natural product biosynthetic pathways. This has given rise to the identification of flavoenzymes that are promising candidates for biomedical and biotechnical applications. This dissertation discusses the …
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Design and Application of Nanostructured Flavin Photocatalysts
… within a range of flavin-containing enzymes (flavoenzymes) that are responsible for metabolic, antioxidant and photoreception processes across animal, plant and bacteria kingdoms. Their broad redox and photochemistry has seen the field of flavin-based catalysis emerge as a powerful addition to …
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Intracellular Dynamics of Hydrogen Peroxide in Escherichia Coli
… However, these results did confirm that specific flavoenzymes, shown in vitro to make H 2O2, can autoxidize and adventitiously contribute to cytosolic H2O2 formation in vivo. However, the most substantial H2O2 generator remains unidentified.
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Biochemical Characterization of Thermocrispum agreste TheA: A Flavin-Dependent N-hydroxylating Enzyme
… the general knowledge and understanding of flavoenzymes, ornithine monooxygenases, and their associated mechanisms.
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Photochemistry, photophysics and spectroscopy of redox states of flavins relevant to photoactive flavoproteins
… model compounds that can mimic the functions of flavoenzymes. This thesis aims a) to explore and enhance the knowledge about the behavior of the flavin cofactors in its different redox states b) to further study and develop the mechanism of BLUF domain protein. To achieve a better understanding …
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Investigation of FAD Chemical Models to Study the Monoamine Oxidase Catalyzed Oxidation of Cyclic Tertiary-Allylamines
… that participates in the redox process of flavoenzymes. Attempts to characterize the catalytic pathways of these enzymes have relied in part on the use of FAD chemical models. The efforts described in this dissertation focus on the chemical model approach to investigate the mechanism of the …
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Biophysical and structural studies of novel F420-dependent oxidoreductases in Mycobacterium tuberculosis
… fragments was designed based on known ligands to flavoenzymes and screened for binding to Rv1155 and Rv2991 in the presence and absence of F420 using STD NMR and differential scanning fluorimetry. Rv1155 and Rv2991 show affinity for distinct classes of fragments. Using a computational method known …
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The Investigation of the Active Sites of Monoamine Oxidase (MAO) A and B and the Study of MAO-A Mediated Neurotoxicity Using 4-Substituted Tetrahydropyridines
The mitochondrial membrane bound flavoenzymes monoamine oxidase A and B (MAO-A and MAO-B) catalyze the a-carbon oxidation of a variety of amines including neurotransmitters such as dopamine and serotonin. Although the primary structures of these enzymes have been established from the corresponding …
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Investigations on the Reaction Mechanism of Xenobiotic Reductase A
… new insights on how substrates interact with flavoenzymes.
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Röntgenstrukturanalyse der 6-Hydroxy-D-Nikotin-Oxidase aus Arthrobacter nicotinovorans sowie Darstellung und Charakterisierung einer Protein-Protein-Kontaktfläche mit der 6-Phospho-ß-Galaktosidase aus Lactococcus lactis
Die 6-Hydroxy-D-Nikotin-Oxidase (6HDNO) aus Arthrobacter nicotinovorans wurde rekombinant exprimiert, gereinigt und kristallisiert. Die Struktur wurde mit röntgenkristallographischen Methoden in drei Kristallformen bis zu einer Auflösung von 1.9 Å gelöst und verfeinert. Das Enzym katalysiert die …