Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"fixed-dose"”.
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Development of fixed dose combinations using advanced engineering technologies
… throughout this thesis in order to produce fixed-dose combination products. Depending on the desired characteristics of the final formulation, selection of appropriate continuous manufacturing platform had a critical impact on the overall outcome. Several continuous manufacturing platforms, …
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Pricing and reimbursement challenges for fixed dose combination cardiovascular drugs and intravenous oncologies
… of drugs were chosen to examine this topic: fixed dose combination (FDC) cardiovascular drugs and intravenous oncologies. FDC cardiovascular drugs were chosen because they are covered under the pharmacy benefit / Part D and are considered to have questionable efficacious value over their …
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Development and Bioavailability/Bioequivalence of a Fixed-Dose Combination Antiretroviral Reconstitutable Suspension Intended for Pediatrics
… bioequivalence of age-appropriate fixed-dose combination granules of lamivudine/zidovudine/nevirapine as reconstitutable suspension for pediatrics for use in pediatric patients. The granules were developed via roller compaction process to improve granule flow characteristics, …
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Investigation of a novel modified fixed dose determination protocol for radioiodine treatment of feline hyperthyroidism
… for feline hyperthyroidism. The ideal method of dose determination of 131I remains controversial. Objective: To compare a method of radioiodine dose determination that utilized thyroid scintigraphy with a standard fixed dose for treatment of feline hyperthyroidism. Methods: Fifty-seven and 23 …
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Sample size determination for Emax model, equivalence / non-inferiority test and drug combination in fixed dose trials.
… considered the problem of drug combination in fixed dose trials to test whether a drug mixture, which may combine two or more agents, is more 'effective' than each of its components. Informative priors are derived for component drugs and a non-informative prior is assumed for the drug mixture. …
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Efficacy of single fixed dose of radioiodine (I-131) therapy in patients with hyperthyroidism at Groote Schuur Hospital
… I-131 therapy in whom treatment with a single fixed dose was successful, as defined by the achievement of euthyroidism or hypothyroidism 6-months after the therapy; To identify patients in whom treatment was not successful and a second dose needed; And, if possible, to establish the factors …
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An Adaptive Dose Finding Design (DOSEFIND) Using A Nonlinear Dose Response Model
… trials are the first time that an NCE is dosed in human subjects, the designs used in these trials are unique and geared toward patient safety. We develop a method for obtaining the desired response using an adaptive non-linear approach. This method is applicable for studies in which MTD, …
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Rates of Switching First-Line Antiretroviral Regimen Tenofovir-Emtricitabine-Efavirenz combination in a Primary Care Service in South Africa
… Tenofovir-Emtricitabine-Efavirenz (TEE) fixed-dose-combination (FDC) has been recommended since 2013 as the first-line antiretroviral therapy (ART) for treating HIV for people living with the virus (PLWH) in South Africa. More evidence has emerged to show long term adverse effects of …
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A scoping review on the use of telerehabilitation in physiotherapy in low and middle income countries
… a bacteriostatic drug, administered as part of a fixed-dose combination regimen for the treatment of tuberculosis (TB). Individuals with comorbid HIV have reported reduced serum concentrations of ethambutol. We aimed to evaluate the pharmacokinetics of ethambutol in individuals with both …
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Resumes Of Diploma Theses (2014) for Master’s Degree in Pharmaceutical Management
… AND ACTAVIS ***** POTENTIAL FOR ADMINISTERING OF FIXED DOSE RAMIPRIL / AMLODIPINE COMBINATION OF THE PHARMACEUTICAL COMPANY EGIS IN VARNA AND DOBRICH ***** MARKETING FORCAST FOR TAMSULOSIN 0.4 MG (TBL.), ASTELLAS PHARMA PRODUCT, IN BULGARIA ***** COMPETITIVENESS ANALYSIS OF INNOAVATIVE PASTILLE …
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Patient Friendly Formulations Utilizing Hot Melt Extrusion Technology
… tablet, fast disintegration films and fixed dose combinations. Previous research demonstrated these applications by conventional formulation techniques which has inherent shortcoming of use of large amount of solvent and batch size manufacturing. This present work addressed some of the …
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Fused deposition modelling three-dimensional printing of solid dosage forms
… sustained release of theophylline (THP). Fixed-dose bilayer floating tablets were also manufactured. This thesis displayed the ability of FDM-3DP to manufacture bespoke floating tablets using pharmaceutical excipients with tailored drug release profiles.<br/><br/><i>Thesis embargoed until …
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Incidence and Prevalence Of Renal Dysfunction In Antiretroviral Therapy (ART) Naïve Patients Starting A Tenofovir (TDF) Based ART Regimen In Mitchell's Plain Community Health Centre (CHC) ARV Clinic
… antiretrovirus (ARV) activity and available in fixed dose combination (FDC). However, it has been found to cause renal dysfunction. Objectives: To document the prevalence, incidence, pattern of occurence and associated factors of nephrotoxicity in patients initiated on TDF based ART regimen in …
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Identifying strategies to inform interventions for the secondary prevention of stroke in UK primary care
… medication taking for secondary prevention (i.e. fixed-dose combination polypill). Findings showed that survivors face considerable barriers to medicine taking, but that facilitators, particularly the caregiver role, can encourage good medication taking practice. The online forum has potential as …
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A systematic review of the blood pressure lowering efficacy of ACE inhibitors and angiotensin receptor blockers for primary hypertension
… tolerability. Objectives: 1) To determine the dose-related effect of ACE inhibitors and ARBs on BP, heart rate and withdrawals due to adverse effects (WDAE), compared with placebo in the treatment of primary hypertension (SBP ≥ 140 mm Hg and/or ≥ DPB 90 mm Hg); and 2) To compare the relative …
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Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated Falciparum malaria
… 28 days in a therapeutic efficacy study of the fixed-dose combination therapy, artesunate-amodiaquine. RESULTS: The day 28 genotype-adjusted adequate clinical and parasitological response rate of artesunate-amodiaquine combination in 321 patients studied was above 97% in both the …
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Pharmacometrics of dolutegravir and tenofovir: a quantitative approach to characterise drug-drug interactions, pharmacogenetics and optimise treatment
… efavirenz- to dolutegravir-based regimens. A fixed-dose combination containing dolutegravir, tenofovir, and lamivudine taken daily constitutes one of the most widely used regimens in Africa. In this thesis, we employ population pharmacokinetic modelling to optimise HIV treatment using data …
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Strategies for optimising TB-HIV co-treatment in children and adolescents with drug-susceptible tuberculosis on rifampicin-based standard regimens
… recommendations for first-line TB drugs using fixed-dose combination tablets. Next, we examined two dose-adjustment strategies involving lopinavir/ritonavir, a widely available protease inhibitor for first- and second -line ART, using both liquid and tablet formulations. We then investigated a …
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