Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"first line therapy"”.
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Prevalence of Pik3ca-Mutations and Response to First-Line Endocrine Therapy in a Population of Bulgarian Patients with HR(+) HER2(–) Metastatic Breast Cancer // Честотата на PIK3CA-мутацията и отговорът към първа линия ендокринна терапия в популацията от български пациентки с HR(+)HER2(-) метастазирал карцином на гърдата
… of the patients and their response to first-line therapy were investigated. The data analysis was retrospective. All patients provided histological samples for examination after signing informed consent. Some of the patients were diagnosed at the metastatic stage, while others were …
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Outcome and prognostic factors of palliative chemotherapy for non-small cell lung cancer patients at single institution: 2002-2011
… cancer patients who received palliative chemotherapy, overall survival, and factors that affect the survival rates. The study subjects were 402 non-small cell lung cancer patients who received palliative chemotherapy during 10 years from January 2002 to December 2011 at a university hospital. …
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Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa
… South African children in need of antiretroviral therapy (ART) were receiving treatment which is a 20% increment in treatment access from 2008 to 2009. With increase in access to treatment, understanding drug tolerability, safety and durability is important especially among children whose drug …
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The use of bempedoic acid in treating hypercholesterolemia
Statins are often the first-line therapy in the treatment of patients with hypercholesterolemia. Though often regarded as relatively low risk and widely effective in treating hypercholesterolemia, statin therapy has a variety of limitations, including statin resistance and statin intolerance. These …
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Recent advances in drug therapy of tuberculosis
The current medications for tuberculosis treatment could cause a lot side effects, and indirectly lead treatment failure by patient intolerance. Scientists are trying to analyze the gene differences in resistant tuberculosis isolates, find out the reason and later target mechanism could be achieved …
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A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga
Following the completion of a detailed baseline study of malaria in the region, a model was developed to assess the cost-effectiveness of switching from chloroquine to sulfadoxine-pyrimetharnine as first line treatment in the Tonga district of Mpumalanga, South Africa, where malaria is seasonal and …
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Evaluating adherence to recommended clinical guidelines for the prevention of cardiovascular disease in patients with Type 2 diabetes mellitus at primary care level
… disease (CVD). Evidence-based guidelines lower cardiovascular risk in diabetics. Adherence to clinical guidelines for the prevention of CVD in South African primary care public sector facilities is unknown. Aim: This study determined adherence of Cape Town primary care clinicians to …
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Impact of Cyclin-Dependent Kinase 4 and 6 Inhibitors on Chemotherapy Utilization and Overall Survival in Women with HR+/HER2– Metastatic Breast Cancer in the United States
Purpose: Delaying chemotherapy remains a vital goal in therapeutic management of HR+/HER2– metastatic breast cancer (MBC). However, recent reports continue to highlight substantially high chemotherapy utilization in earlier therapy lines. In this study, we explored the impact of cyclin-dependent …
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Inhibition of Urothelial Carcinoma By Type I Interferon Activation of The Innate and Adaptive Immune Response
<p>Bacillus Calmette-Guerin (BCG) is the first line therapy for bladder cancer patients with non-invasive disease. However, roughly 40% of patients exhibit no response, tumor recurrence or tumor progression following BCG treatment. Type I interferon (IFN-I) has potent anti-tumor effects against …
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Factors associated with different responses to combination antiretroviral therapy in an observational cohort study of HIV-1 infected patients
The introduction of combination antiretroviral therapy (cART) into clinical practice for the treatment of HIV in 1995-1996 has led to dramatic reductions in mortality and morbidity. Factors linked to a positive response to therapy include a potent and tolerable regimen, good adherence and low …
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Ethosuximide stabilizes sleep-related oscillations and reduces sleep fragmentation during alcohol withdrawal
… risk of relapse. Furthermore, the current first-line therapy for alcohol withdrawal, chlordiazepoxide, is inappropriate for long-term management of AWI due to potential for abuse and negative side effects. While much of the research into the mechanisms underlying AWI has focused on …
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Variability in Pricing of Generic Antipsychotic Medications Used in the Treatment of Schizophrenia at Community Pharmacies in the Kansas City Metropolitan Area
… ziprasidone, and aripiprazole) recommended for first line therapy in the treatment for schizophrenia is lacking. Pharmacy-level variability in retail cash pricing for five generically available second-generation and one first-generation antipsychotic medications at therapeutic doses for the …
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Preparation, Characterization and In Vitro Evaluation of Metformin Loaded Hyaluronic Acid Nanoparticles for Oral Delivery
… indicated that the drug was present in a crystalline state in the matrix. The in vitro drug release studies showed that >50% of metformin was released within one hour. Metformin nanoparticles were non-toxic at a concentration of ≤ 100 µM in Cacco-2 cells. Haemolysis studies indicated that these …
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Psychological Well-Being and Health-Related Quality of Life Following Ventricular Tachycardia Ablation, A Prospective Study
… cardioverter defibrillators (ICD) are first-line therapy for treatment of VT. However, ICD shocks can have a profound impact on psychological well-being and health-related quality of life (HRQoL). Catheter ablation of VT is a novel procedure intended to reduce VT recurrence, medication …
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Role and Regulation of Epha2 In Pancreatic Cancer
… cause of death in the US. Gemcitabine is the first-line therapy for this disease, but unfortunately it shows only very modest benefit. The focus of the current study was to investigate the role and regulation of EphA2, a receptor tyrosine kinase expressed in PDAC, to further understand this …
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The prevalence of Legionella and mycoplasma seropositivity in the elderly in Cape Town
… are increased in those in whom initiation of therapy with an appropriate agent has been delayed. Whereas Mycoplasma pneumoniae and Legionella pneumophila are sensitive to the macrolides or tetracycline, they do not respond to the currently recommended first-line agents for community acquired …
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Toxicities associated with antiretroviral treatment of HIV-1
… associated with ABC/3TC and TDF/FTC. The first study compared cardiovascular safety profiles of the two ART by examining CVD biomarkers. The second identified baseline predictors of limb fat recovery. A final study identified specific HLA genotypes associated with body composition changes. …
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High flow nasal oxygen versus mechanical ventilation as initial respirator support in severe COVID-19 ARDS at Groote Schuur Hospital : a propensity score analysis
… Hospital in Cape Town, South Africa, during the first COVID wave. Patient received MV if HFNO failed. The purpose of this study was to compare outcomes of this “HFNO first” strategy to a “MV first” strategy. METHODS: This was a secondary analysis of two propsective cohort studies conducted during …
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Human Endogenous Retrovirus K As A Novel Tumor-Associated Antigen For Development of An Ovarian Cancer Vaccine
… are currently lacking and most women first present with either stage III or IV disease. To date, there has been no substantial decrease in death rates and the majorities of patients relapse and die from their disease despite response to first-line therapy. Several proteins, such as …
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Treatment of prepubertal labial adhesions: a randomized, double-blinded trial comparing topical emollient versus topical estrogen
… estrogen had traditionally been considered first-line therapy, this method of treatment can be associated with alarming side effects in prepubertal girls including breast budding and vaginal bleeding. This clinical study aimed to assess the need for estrogen for treatment of prepubertal …
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