Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"filovirus"”.
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Aptamers that bind filovirus GP : a new frontier for detection and neutralization of Ebola and Marburg virus
… of aptamers that have an affinity for filovirus surfaces. I first describe the development of an improved method for purifying highly lytic vesicular stomatitis virus-based filovirus GP displayed surrogate viruses. Filoviruses are highly pathogenic and thus require highly secured …
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Spillover and emergence of bat-origin viral infections
… animals as bridging hosts of henipavirus and filovirus spillover, a statistical model of Ebola spillover observation probabilities, and a Bayesian model of syndromic differentiation of and surveillance for haemorrhagic fevers. By adapting, extending, and developing new analytical methods to …
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Elucidating the Immunogenicity and Protective Immune Response of a Trivalent Vaccine for Sudan Ebola, Marburg, and Lassa Fever Viruses
… antibodies targeting several circulating filovirus strains. While a homologous prime-boost immunisation schedule was superior in BALB/c mice, the vaccine-induced immune response in guinea pigs benefitted from a heterologous prime-boost regimen. Importantly, all immunised animals (n=5) …
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Sphingomyelinases and Lysosomal Trafficking in Ebolavirus Entry
… (EBOV) is a negative sensed, single-strand filovirus which causes up to 90% mortality. Despite increasing outbreaks over the past decade, no approved vaccines or therapies exist. One drug treatment strategy is to target virus entry mechanisms. EBOV enters the cell using a …
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The study of highly pathogenic emerging zoonotic virus envelope proteins through pseudotyped virus generation
… studies to assist their development, a panel of filovirus PVs were rapidly produced. Work was carried out to optimise their method of production; determining lentiviral core PV produced by transfecting HEK 293T/17 cells was most efficient. Efforts to repeat the use of chimeric envelope proteins …
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Bundibugyo Versus Zaire Ebolaviruses: Examination of the Polymerase Complex as a Therapeutic Target
Ebolaviruses, of the family Filoviridae, are the causative agents of outbreaks of hemorrhagic fever throughout Africa. In eastern Africa, three outbreak causing species of ebolavirus overlap in geographic distribution: Zaire ebolavirus (EBOV), Sudan ebolavirus (SUDV), and Bundibugyo ebolavirus …