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Showing 1 to 11 of 11 for “"filamin A"”.

  1. The cross-linking mechanism of filamin A in the actin cytoskeleton

    Hartemink, Christopher Allan, 1974-Massachusetts Institute of Technology2005

    … confer to the cell its mechanical properties. Filamin is an abundant actin-binding protein that efficiently cross-links actin filaments in large-angle orientations, requiring the lowest concentration to convert actin filaments into a cohesive gel. Filamin dimers are composed of two 24-repeat …

    mit Repository record

  2. The Role of Rac and Filamin A in Osteoclast Function and Osteoclast Heterogeneity

    Goldberg, Stephanie2015

    … in osteoclasts lacking actin binding protein Filamin A (FLNA), which interacts with Rho GTPases to regulate osteoclast formation (osteoclastogenesis (OCG)) and function. It was observed using this technique that FLNA-knock-out (KO) osteoclasts were smaller and produced shallower Rpits compared …

    toronto-retro Repository record

  3. Identifizierung und Charakterisierung neuer intrazellulärer Bindungspartner von CEACAM1-L und deren Einfluss auf CEACAM1-L-vermittelte zelluläre Funktionen

    Klaile, Esther2006

    In dieser Arbeit wurde Filamin A als neuer intrazellulärer Interaktionspartner von CEACAM1-L identifiziert. Um die funktionelle Auswirkung der Interaktion von CEACAM1-L und Filamin A zu untersuchen, wurde ein humanes Melanom- Zellsystem etabliert, dass die Filamin A- und CEACAM1-L-negativen …

    fu-berlin Repository record

  4. The filamin A actin binding domain structure and function: implications for a gain-of-function mechanism for the otopalatodigital syndrome: a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, Palmerston North, New Zealand

    Clark, Alice Rosemary2010

    massey

  5. Genomic Approaches to Congenital Genitourinary Disorders

    Harrison, Steven Michael2016

    … PBS brothers identified a missense mutation in Filamin A and functional testing suggests this mutation impairs muscle cell contraction and mechanosensing. Candidate genes identified from sequencing the exomes of unrelated patients are hypothesized to have similar effects on cellular function, …

    utswmed Repository record

  6. Actin remodeling in motile cells

    Osborn, Eric A. (Eric Alan), 1975-Massachusetts Institute of Technology2004

    … state and after orthogonal cross-linking with filamins using a novel, non-perturbing fluorescence system. Human filamin A or Dictyosteliun discoidium filamin slow actin filament turnover by [approximately] 50% and recruit much of a significant population of actin oligomers that we measure are …

    mit Repository record

  7. Mapping the actin and actin binding proteins interactions : from micromechanics to single molecule force spectroscopy

    Ferrer, Jorge M., 1976-Massachusetts Institute of Technology2007

    … assay by testing it with two different ABPs: filamin, a crosslinker, and a-actinin, a bundler. We measured rupture forces of 28-73 pN and 30-56 pN for filamin/actin and a-actinin/actin respectively, suggesting that the former is a slightly stronger interaction. Moreover, since no ABP unfolding …

    mit Repository record

  8. MOLECULAR MECHANISMS UNDERLYING CLINICAL BEHAVIOR OF NEUROENDOCRINE TUMORS: STUDY OF NEW POSSIBLE BIOMARKERS PREDICTABLE OF PHARMACOLOGICAL RESISTANCE AND TARGETS

    MANGILI, FEDERICAUniversità degli Studi di Milano2023

    … Moreover, the cytoskeleton actin binding protein filamin-A (FLNA) emerged as an important player in the regulation of PitNETs drug responsiveness and invasiveness. At this regard our data showed that activation of the cAMP pathway and DRD2 agonist regulated FLNA activity by increasing or …

    milano Repository record

  9. Investigating DNA Methylation Changes in a Preclinical Murine Model of Cutaneous Squamous Cell Carcinoma

    Roth, KevinUniversity of Dundee2019

    … methylation in the tumor suppressor gene Filamin A interacting protein 1 like (Filip1l). Down-regulation of the FILIP1L gene has been linked to ovarian, prostate and pancreatic cancer aggressiveness and metastatic potential and is an independent prognostic marker in ovarian cancer …

    dundee Repository record

  10. THERAPEUTIC POTENTIAL OF TARGETING THE FLNA-REGULATED WEE1 KINASE PATHWAY IN ADRENOCORTICAL CARCINOMAS.

    ESPOSITO, EMANUELAUniversità degli Studi di Milano2025

    … benign adenomas (ACA), the cytoskeletal protein filamin A (FLNA) is poorly expressed in ACC. Of note, its presence, even at low levels, is associated to a less aggressive tumor behaviour, potentially due to its role in negatively regulating the insulin-like growth factor 1 receptor (IGF1R) …

    milano Repository record

  11. The Master Synaptic Regulator: Activity Regulated Cytoskeleton Associated Protein, Arc, in Normal Aging and Diseases with Cognitive Impairment

    Khan, AmberThe Graduate School and University Center of The City University of New York2021

    … that Arc is associated with PSD-95/NMDAR and filamin A (FLNA) signaling pathways. Further, we identify protein kinase C (PKC) and Src in the PSD-95/NMDAR complexes as well as JAK2 and PAK1 in the FLNA signaling cascade as the kinases that phosphorylate Arc following activation of the NMDARs …

    cuny-grad Repository record