Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"filament bundles"”.
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Material properties of actin filament bundles
… to Limulus that decorates and crosslinks actin filaments into a crystalline bundle. Our goal is to reconstitute the structure of the acrosome using these two proteins in order to further elucidate the role of scruin in actin bundle crosslinking.A multi-scale approach is presented wherein the …
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A Platform for Analyzing Force Sensitivity and Multivalency in Actin Networks
… properties. These networks are composed of actin filaments and numerous actin binding proteins (ABPs), many of which engage multiple filaments simultaneously to crosslink them into specific functional architectures. Mechanical force has been shown to modulate the interactions between several ABPs …
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Role Of Actg2 Mutations In Visceral Myopathy
… effects of ACTG2 R257C on organization of actin filament bundles and actin-mediated cellular functions in cultured primary human intestinal smooth muscle cells (HISMCs) (Chapter 2). I discovered that the ACTG2 R257C mutation led to fewer, shorter, thinner, and less branched ACTG2 filament bundles …
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Determining alpha-smooth muscle actin expression in embryonic and mesenchymal stem cells of assorted mammals seeded in collagen scaffolds in vitro
… the embryonic scaffolds did not generate actin filament bundles, and that several of the mesenchymal stem cell seeded scaffolds were imaged after [alpha]-SMA expression in them ceased.
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Mechanics of the hysteretic large strain behavior of mussel byssus threads
… et. al. (2004), consists of tiny banana-shaped filament bundles, with molecular folded domain ends. It is demonstrated that as the thread is stretched these bundles straighten and the ends unfold, increasing the tension-free length of the filaments. Further stretching is required to load this …
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Processive Acceleration of Actin Barbed End Assembly by N-WASP
… to activating Arp2/3 complex, N-WASP binds actin filament barbed ends, and both N-WASP and barbed ends are tightly clustered in these invasive structures. We used nanofibers coated with N-WASP WWCA domains as model cell surfaces and single actin filament imaging to determine how clustered N-WASP …
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Actin polymerization dynamics at the leading edge
… motility in vitro to investigate how actin filaments are organized to coordinate elongation and attachment to leading edge. Using total internal reflection fluorescence microscopy of actin filaments, we tested how profilin, Arp2/3, and capping protein (CP) function together to propel beads …
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Conformations of semiflexible polymers and filaments
… of semiflexible polymers, such as DNA, actin filaments and carbon nanotubes, strongly depend on their rigidity. Semiflexible polymers are characterized by their persistence length, the definition of which is the subject of the first part of this thesis. Attractive interactions, that arise …