Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"filaggrin"”.
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Increased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria
국문요약 i 차례 iⅱ 그림차례 iv 표차례 v Ⅰ. 서론 1 Ⅱ. 연구대상 및 방법 3 Ⅲ. 결과 8 Ⅳ. 고찰 13 Ⅴ. 결론 19 참고문헌 20 ABSTRACT 27
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Improving the skin barrier function in atopic dermatitis
… affecting the epidermal barrier protein filaggrin. Filaggrin aggregates keratin filaments during terminal keratinocyte differentiation, allowing normal epidermal stratification. The role of filaggrin in maintaining a functional skin barrier is further supported by a clinical study …
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Intrinsic alterations of the skin barrier function promote the pathogenesis of atopic dermatitis in dogs
… natural antimicrobial peptides (AMPs) and filaggrin. Antimicrobial peptides are small proteins secreted by many mammalian epithelial cells. Their main functions include: defense against external pathogens, orchestration of the innate and adaptive immunity, and regulation of the normal local …
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Skin barrier dysfunction in common genetic disorders
… an indispensable role in barrier formation is filaggrin, which is encoded by the filaggrin gene (FLG) that lies within a cluster of epidermal genes known as the epidermal differentiation complex (EDC) on chromosome 1q21. Recent studies in Europe have shown that null mutations in FLG lead to the …
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The Role of Polycomb Repressive Complex 2 in Epidermal Homeostasis and Hair Growth
… of terminal differentiation genes, such as Filaggrin. EZH2 expression was downregulated in aged keratinocytes accompanied with upregulation of senescence-associated genes, p16INK4A and p19INK4D, suggesting EZH2 involvement in epidermal aging. In human anagen hair follicle (HF), EZH2 was …
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Molecular and Genetic Mechanisms in Atopic Eczema
… loss-of-function mutations in the gene encoding filaggrin (FLG). FLG null mutations play a major role in eczema and other atopic diseases and my work has built on this seminal discovery. I described, for the first time, transcriptomic features of FLG haploinsufficiency (Cole et al. J Allergy Clin …
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Molecular and functional analyses of human synovial B-lymphocytes in rheumatoid arthritis
… tetanus toxoid, mitochondrial antigens (M2), filaggrin and bacterial HSPs. The contributions of these antigens to the pathogenesis of RA are still hypothetical. A possible contribution could derive from crossreactivity and epitope mimicry: due to crossreaction, an antibody directed originally …
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Characterizing various aspects of the male genital tract barrier function and immunity
… scoring and gene expression using RTqPCR of Filaggrin, Involucrin, E-cadherin and Claudin. Spatially resolved gene expression in CD68+ macrophages and pan-cytokeratin epithelial cells was made from 8 foreskin tissue samples dissected into inner and outer tissue. Using a DeltaVision Elite …