Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"fih"”.
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Characterising Novel Substrates of the Asparaginyl Hydroxylase FIH
Factor Inhibiting the Hypoxia Inducible Factor (FIH) is an oxygen-dependent asparaginyl hydroxylase that plays a role in the cellular response to changes in oxygen concentrations. It was first found to catalyse the post translational hydroxylation of a family of transcription factors known as …
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Metabolic control of immune cell fate by hypoxia-inducible factors
… In Chapter 3, the role of factor inhibiting HIF (FIH) in directing T cell metabolism and fate is explored. Using a mouse T cell-specific FIH knockout model, FIH is shown to regulate T cell differentiation in an oxygen-dependent manner. Furthermore, by considering a metabolic network of related …
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Confirmatory research of Minsky’s financial instability hypothesis for the 1945-2017 era
… known as the Financial Instability Hypothesis (FIH). If such theory holds true, its application could be used to forecast future business cycles to improve engineering economic decisions. However, the current literature shows a lack of proper methodology to confirm whether this theory is valid …
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The role of mitochondria in regulating smooth muscle cell proliferation and migration in pulmonary hypertension
… and a decrease in hypoxic genes (HIF1α and FIH-1).Interestingly, despite the reduced DRP1 expression and the presence of elongated mitochondria that were observed in the PDGF stimulated cells during hypoxia, inhibiting mitochondrial fission in these cells with Mdivi-1 slows cell …
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The role of the chromatin remodeller ISWI in the cellular response to hypoxia
… Prolyl-Hydroxylases and Factor Inhibiting HIF (FIH). In order to activate genes, HIF has to access sequences in DNA that are integrated in chromatin. It is known that the chromatin remodelling complex SWI/SNF (Switch/Sucrose non-fermenting) is essential for HIF activity. However, no additional …
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Characterization of Novel Substrates of the Tankyrase and RNF146 Destruction Complex and Mechanisms of its Regulation
… how Tankyrase PARylation is regulated through FIH dependent hydroxylation. I have identified SH3BP5 and SH3BP5L as new Tankyrase substrates that are targets of RNF146. I have shown that both substrates are guanine exchange factors for the small GTPase Rab11a. I have defined the minimal …
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‘So proved themselves supreme in women’s hockey throughout the world’: a history of English and British international women’s hockey 1951–2016
… or the Fédération Internationale de Hockey (FIH). This changed after the early 1970s when the sport experienced renewed external influences not seen in previous generations, from the British government’s increasingly interventionist sport policy and the IOC’s ambivalence towards amateurism. …
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Characterising mechanisms of regulation of hypoxia-inducible factors.
… that the protein factor inhibiting HIF-1 (FIH-1), previously shown to interact with HIF, is an asparaginyl hydroxylase enzyme capable of hydroxylating the asparagine in the HIF CAD. Like other known hydroxylases FIH-1 is an iron and 2- oxoglutarate-dependent enzyme that uses molecular …
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Job Sequencing & WIP level determination in a cyclic CONWIP Flowshop with Blocking
… approach called the Fast Insertion Heuristic (FIH) coupled with a method to appraise the quality of every enumeration at each iteration. This is done by using a modified version of the Floyd's algorithm, to determine the cycle time (or Flow time) of a partial/full solution. The performance …
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The Mammalian Hypoxia Response Pathway: Regulation of HIF and HIF Prolyl Hydroxylases
… degradation. Factor Inhibiting HIF 1 (FIH-1, an asparaginyl hydroxylase), on the other hand, hydroxylates C-terminal Transactivation Domain (CTAD) thereby abolishing recruitment of transcriptional co-activators by HIF alpha. However, under hypoxic conditions, both hydroxylations are …
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Oxygen-dependent regulation of the activating transcription factor-4 (ATF-4)
… oder PHD2 sowie dem HIF-inhibierenden Faktor (FIH) nachgewiesen werden. ATF-4 ist an der Regulation der zellulären Stressantwort beteiligt und seine Expression wird wiederum durch verschieden Arten von Stress induziert. Weiterhin ist gezeigt worden, dass ATF-4 posttranslationell und auf Ebene …
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Evaluating Travelers Experience with Highway Advisory Radio (HAR) And Citizens Band Radio Advisory System (CBRAS) On Florida's Turnpike Enterprise Toll Roadways And Florida Interstate Highways
… on both Florida Interstate Highway system (FIH) and the Florida Turnpike Enterprise (FTE) toll roads. To achieve this goal, two different survey tools were used. The first tool is a random digit dialing phone survey known as CATI (Computer-Assisted Telephone Interviewing). The second tool is …
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Incidence of injuries and associated factors at the senior inter provincial field hockey tournament
… who had a Federation of International Hockey (FIH) qualification had lower injury incidence rates compared to players with coaches who did not hold this qualification (p = 0.015; Fisher exact), with a lower incidence of injury in players coached by a FIH qualified coach (logistic regression …
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Ir-rappreżentazzjoni tas-sess f’Jutta Heim ta’ Immanuel Mifsud
… li niffoka fuq l-introduzzjoni għaliex tiġbor fiha r-riflessjonijiet ewlenin dwar dak li ntqal fuq il-ġisem. Il-kumplament tax-xogħol ta’ Mifsud niddiskutih filkapitli ta’ wara għaliex inħoss li hu iktar utli nuża l-informazzjoni li sibt f’din it-teżi biex insaħħaħ jew nibni argumenti …
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Il-makkjetta : riċetta Maltija għall-buri u l-geddum
… kien kbir, tant li jilħaq is-sittin ruħ. Dawn fihom infushom jidhirli li huma ġabra ta’ interess kbir għal min irid jissokta fl-istudju tal-ispettaklu popolari f’Malta. Ħafna minn dawn it-traskrizzjonijiet ma stajtx indaħħalhom fit-teżi minħabba l-ispazju, imma xorta waħda wieħed jista’ jsibhom …