Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"fic"”.
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Genetic Analysis of Fic-Mediated BiP AMPylation in Photoreceptors
… Depending on ER stress levels, the ER-resident Fic protein catalyzes AMPylation or deAMPylation of BiP, the major ER chaperone. This work elucidates a critical role of the reversible AMPylation of BiP in maintaining the Drosophila visual system in response to constant light-induced stress. In …
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Structural studies on the LINC complex and Fic-1
… or KASH2 peptides. In this project testes-specific human SUN proteins (SUN3, SPAG4, and SUNS) were compared to ubiquitously-expressed SUN2. Secondly, fission and budding yeast LINC complexes differ from human ones and were analyzed as well. I was able to confirm SUN-KASH interaction in human and …
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Fic-Mediated AMPylation in Bacterial Infection and Endoplasmic Reticulum Stress
The post-translational modification AMPylation is emerging as a significant regulatory mechanism in both prokaryotic and eukaryotic biology. This process involves the covalent addition of an adenosine monophosphate to a protein resulting in a modified protein with altered activity. Proteins capable …
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Structural and Kinetic Characterization of Protein Ampylation by VopS Fic Domain
… catalyzed by known AMPylators including Fic domain and adenylyltransferase domain proteins. Further, we showed that N6pATP can be used for the detection and purification of endogenous AMPylated proteins. Preliminary studies were performed on another effector protein of unknown function, …
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Pharmacological and Non-pharmacological Prevention of Fentanyl-Induced Cough : A meta-analysis
Fentanyl-induced cough (FIC) is often observed after intravenous bolus administration of fentanyl during anesthesia induction. This meta-analysis assessed the efficacy of pharmacological and non-pharmacological interventions to reduce the incidence of FIC. We searched for randomized controlled …
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The economic and financial feasibility of food innovation centers
A Food Innovation Center (FIC) is an enclosed commercial space comprising a mix of complementary uses pertaining to locally-operated food growing, production, processing, testing, distribution, and sale. These uses include indoor vertical farms, commercial shared-use kitchens for start-up food …
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Post-translational regulation of BiP by FICD-mediated AMPylation and deAMPylation
… response (UPR). Conversely, a metazoan-specific, endoplasmic reticulum (ER)-resident, Fic domain containing protein (FICD) is able to dynamically adjust BiP’s activity through AMPylation and deAMPylation. These two mutually antagonistic reactions, catalysed by the single active site of FICD, …
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Characterization of Vibrio VopS, an AMPylator of Rho GTPases
… VopS, contains a Filamentation induced by cAMP (Fic) domain that we have shown is critical for the function of this effector. Our studies have found that VopS inhibits Rho GTPase signaling during infection by directly modifying Rho, Rac, and Cdc42, preventing their interaction with downstream …
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Evaluation of Antibiotic Drug Synergisms Against Periodontal Aggregatibacter Actinomycetemcomitans
… the fractional inhibitory concentration (FIC) index was calculated per each antibiotic in combination. FIC index values of less than or equal to 0.5 indicated the presence of synergistic antimicrobial effects of the antibiotic combination against the test bacterial clinical isolates, …
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Atividade sinérgica do citral em associação com antimicrobianos convencionais frente à Enterococcus faecalis multirresistentes
… Índice de Concentração Inibitória Fracionada (FIC index). O citral foi o mais eficaz frente as cepas de Enterococcus faecalis avaliadas quando comparado ao linalol. Os valores do FIC index variaram de 0,5 a 0,125 sugerindo uma interação sinérgica para todas as associações exceto com gentamicina …
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A Microstructural Model for Flow -Induced Crystallization With Applications to the Simulation of Polymer Processes
… as well as other polymer processes involving FIC.
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Challenging attitudes towards people with impairment within the UK and Chilean workplace
… and the second, a quantitative phase to test the FIC model developed. Results confirm that people’s attitudes arise from a circle of permanent stigmatization, which is activated by factors (activators) categorised in three dimensions according to the ABC model of attitude structure. That is …
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Desequilíbrio de ligação e mapeamento associativo em populações de milho-pipoca relacionadas por ciclos de seleção
… (MA) refere-se à associação estatística significativa entre o marcador molecular e a característica fenotípica. Os objetivos deste trabalho foram: (1) estimar o desequilíbrio de ligação em populações de milho pipoca relacionadas por ciclos de seleção utilizando marcadores SNP, (2) comparar as …
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AN ANALYSIS OF THE BUCKLING BEHAVIOR OF SPINAL ANESTHESIA NEEDLES
… force and the critical buckling force, termed ∆FIC, should be considered when choosing a needle to best detect and prevent a buckling complication. Needle gauge was the most significant factor affecting ∆FIC results, followed by tissue depth, needle brand and use of a stylet. The results of this …
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The microbiology of diabetic foot infections: a Ghanaian perspective
… AI–2 quorum sensing molecules which significantly increased biofilm formation and fold induction of bioluminescence in a luxS mutant V. harveyi reference strain. Quorum sensing (QS) inhibition assays using baicalin hydrate, cinnamaldehyde and 2(5H)–furanone showed considerable inhibition …
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The fan fiction reading guide: the use of multimedia and comments as close reading tools
… the benefits of including multimedia in fan fiction multimedia and its effects on the close-reading and critical analysis skills of readers. By completing an illustrative and cumulative case study with three fan fiction authors who are currently writing and publishing a new fiction (fic), the …
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Výroba středního kola objemovým tvářením
Pavel Fic: Výroba středního kola objemovým tvářením. Bakalářská práce. Kombinované studium bakalářského studijního programu Strojírenství, Obor Strojírenské technologie. 3.ročník, letní semestr, akademický rok 2009/2010. FSI VUT v Brně, ÚST - odbor technologie tváření kovů a plastů, květen 2010, …
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Uncovering Reversible AMPylation of BiP Mediated by dFic During ER Homeostasis
AMPylation is a posttranslational modification involving a covalent attachment of an AMP moiety from ATP to hydroxyl side chains of target substrates. Fic domain which mediates AMPylation is highly conserved across species, including higher eukaryotes, implicating an essential role of this …
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Uncovering Reversible AMPylation of BiP Mediated by dFic During ER Homeostasis
AMPylation is a posttranslational modification involving a covalent attachment of an AMP moiety from ATP to hydroxyl side chains of target substrates. Fic domain which mediates AMPylation is highly conserved across species, including higher eukaryotes, implicating an essential role of this …
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Caracterización de liofilizado de maqui (Aristotelia chilensis (Mol.) Stuntz) y su incorporación a una matriz alimentaria tipo película comestible
… interés por el consumo de alimentos benéficos para la salud humana por parte de la población, los berries adquieren cada vez más protagonismo en este nuevo estilo de vida sana. Dentro de ellos, destaca el maqui (Aristotelia chilensis (Mol.) Stuntz), berry nativo chileno conocido por su …
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