Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"fibroids"”.
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Novel Effects of Simvastatin on Uterine Fibroids
Uterine fibroids (also known as leiomyomas) represent a common gynecologic problem with a significant medical and economic burden. Unfortunately, no satisfactory long-term medical treatment is currently available. Statins are drugs commonly used for the treatment of high plasma cholesterol levels. …
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The clinical presentation of women with symptomatic uterine fibroids requiring surgery
Uterine fibroids are the most common tumors among women of reproductive age, affecting more than 70% of women worldwide. Ethnicity influences the development of uterine fibroids and women of African origin are particularly affected. However, despite the high incidence and prevalence of uterine …
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Computer Simulations for Applications of Magnetic Resonance Guided Focused Ultrasound Surgery (MRgFUS) of Uterine Fibroids
Uterine fibroids (UF)s are extremely common growths of the uterus, which despite generally being benign impose a considerable health burden: several hundred thousand hysterectomies for UF treatment are performed annually in North America. Magnetic resonance guided focused ultrasound surgery …
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Investigation of Microstructure of Uterine Fibroids in Magnetic Resonance guided High Intensity Focused Ultrasound Therapy
Uterine fibroids are the most common benign tumors in women. Uterine fibroids can cause substantial symptoms including heavy menstrual bleeding, pelvic pressure, and discomfort. MR guided high intensity focused ultrasound (MRgHIFU) uses MRI to monitor thermal ablation of uterine fibroids. It is …
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Role of MicroRNA-29 and ADAM12 in the Regulation of REST Dependent Signaling Pathways in Uterine Fibroids
Uterine fibroids, also known as leiomyomas, are benign smooth muscle cell (SMC) tumors of the myometrium and are the most frequent reason for a hysterectomy. Although benign, these tumors pose a significant burden on patients with symptoms of abdominal pain, pressure, uterine bleeding, and …
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Dietary intervention with whole flaxseed or vitamin D has beneficial effects on leiomyomas in the oviduct of the laying hen
Uterine leiomyomas, or fibroids, have a symptomatic incidence of around 40% and are a leading cause of reproductive morbidity in reproductively-aged women. Symptoms include menorrhagia, pelvic pain, and infertility. They are characterized by excessive production of extracellular matrix components, …
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The Role of Three-dimensional Ultrasound in the Diagnosis and Treatment of Uterine Pathology
… pathology. We performed serial measurements of fibroids over a period of time to examine their natural history. We found that fibroids tend to grow at a relatively fast average rate in pre-menopausal women, which is influenced by the initial fibroid volume and patients’ demographic …
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Characterization of signalling cross-talk between the EP2 and FP receptors in endometrial epithelial cells
Uterine fibroids are benign tumors that arise from the smooth-muscle uterine cells (myometrium) and are the most common uterine disorder occurring in as many as 30% of women over 35 years of age. Despite their frequent occurrence, the etiology of uterine fibroids is not well elucidated. Several …
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The accuracy of 2D transvaginal ultrasound in the diagnosis of benign endometrial pathology: a comparison between ultrasonography and hysteroscopy
… identified at histology were polyps and fibroids. For those patients who had a normal endometrium at ultrasound (n=59), hysteroscopy revealed 33.9% polyps, 5.1% submucosal fibroids and 49.2% normal/atrophic endometrium. The remainder of these patients demonstrated proliferative or …
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The efficacy of intra-arterial lignocaine as an adjuvant analgesic in the management of post-procedural pain following uterineartery embolization for symptomatic uterine fibroids – a comparative study of outcomes
… artery embolisation (UAE) for symptomatic fibroids has been shown to be an effective and beneficial procedure in our South African population, especially considering any cultural stigma related to hysterectomy. Post procedural pain following UAE can be very significant. Regular review of …
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Gimdos miomos. Klinikinio atvejo pristatymas ir literatūros apžvalga /
… to understand the mechanism of uterine fibroids, the clinical features of the disease, the main methods of treatment and diagnosis, and to describe a clinical case. Methods: The literature search was performed in the PubMed database. The selection criteria were: english language and …
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Determining the endometrial phenotype of women with abnormal uterine bleeding
… of AUB. Two common structural causes of AUB, fibroids and adenomyosis, impact the myometrium, yet, the mechanism by which the endometrial phenotype might be modified, with consequent AUB, is unknown. Research to-date has predominantly investigated the cellular and molecular changes occurring …
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Development of positioning devices for MRI-guided high intensity focused ultrasound (HIFU) for abdominal, thyroid and brain, tumours
… kidney, liver, pancreas, thyroid, uterine fibroids and pancreas. Meanwhile, new investigations are underway for treading cardiac arithmia, strokes, palliative pain treatment of bone metastases and brain disorders such as Parkinson’s disease, essential tremor, and neuropathic pain. These …
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High-Rate Histotripsy Methods for the Rapid Removal of Soft and Fibrous Tissue
… propose histotripsy for the ablation of uterine fibroids, which are large, fibrous tumors that would require unsuitably long treatment times using traditional histotripsy methods. To deliver higher doses and treat larger volumes within a clinically relevant treatment time, (2) I investigate the …
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Health disparities, environmental toxicants, and midlife women’s health outcomes
… phthalate exposure and its associations with fibroids and body mass index at menopause, three statistical methods for phthalate mixture analysis were conducted. We evaluated and compared the predictive capabilities of principal component regression, weighted quantile sum regression, and …
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SYNTHESIS OF PHARMACOLOGICALLY ACTIVE MOLECULES THROUGH BIOCATALYTIC APPROACHES: STUDY OF THEIR STEREOCHEMISTRY AND POLYMORPHISM BY MEANS OF SPECTROSCOPIC AND CRYSTALLOGRAPHIC METHODS.
… diseases, such as endometriosis and uterine fibroids. This PhD project was focused on this drug, studying its conformational features, and improving the synthetic procedures found in the literature. Firstly, theoretical experiments revealed that this drug exists in solution as a mixture of …
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Small molecule inhibitors: novel probes of progesterone receptor action
… as useful treatments for endometriosis, uterine fibroids, and breast cancer. We have identified a set of small molecules that uniquely act outside of PR’s ligand-binding pocket and selectively inhibit PR activity in intact cells. These small molecules inhibit PR-mediated induction of the mouse …
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A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma
Uterine Leiomyoma (UL), also known as Uterine Fibroids, are benign, hormone-sensitive tumors arising in the smooth muscle tissue layer of the uterus, the myometrium. UL are the most common female reproductive tract tumors, with lifetime occurrence in up to 77% of all women. A third of women with UL …
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The Role of PRICKLE1 in the Regulation of Uterine Structure and Physiology
… such as uterine leiomyoma (UL, uterine fibroids), myometrial cell and ECM deposition and organization are disrupted through fibrosis. Despite its importance, the mechanisms governing uterine cell organization, the impact of ECM organization, and uterine fibrosis remain poorly understood. …
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Acupressure and its use for dysmenorrhea
The purpose of this study was to determine the effect of acupressure applied to the Ho-ku acupuncture point (on the hand between the index finger and thumb) on dysmenorrhea and attitudes towards menstruation. Sixty menstruating women were randomly assigned to a control group and an experimental …
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