Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 862 for “"fibroblasts"”.
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Excitable fibroblasts! : ion channels, gap junctions, action potentials and calcium oscillations in normal rat kidney fibroblasts
Contains fulltext : 19366.pdf (Publisher’s version ) (Open Access)
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REPROGRAMMING LUNG FIBROBLASTS INTO LUNG PROGENITORS
… of one cell type directly into another; fibroblasts have been reprogrammed into neural, cardiac and hepatic lineages using forced expression of lineage-specific transcription factors. This strategy offers the possibility of regenerating damaged tissue in vivo by reprogramming resident …
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Mechanism of Metformin Action in Dermal Fibroblasts
… in hepatocytes. However its effects in dermal fibroblasts are unknown. Furthermore, up to 90 percent of burn patients develop hypertrophic scars due to dysregulated collagen secretion, which can lead to functional impairment due to excessive collagen deposition associated with hypertrophic …
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Fibroblasts: Key Cells in Inflammation and Fibrosis
… a pro-inflammatory cytokine that is secreted by fibroblasts and macrophages in the aortic adventitia and promotes the development of aortic dissections. In our previous work, analysis of aortic adventitial fibroblast secretions in vitro suggested that aortic fibroblasts were the main producers …
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DIRECT REPROGRAMMING OF HUMAN FIBROBLASTS INTO CARDIOMYOCYTES
Direct reprogramming of human fibroblasts into induced cardiomyocytes (iCMs) offers a potential therapeutic approach for cardiovascular disease yet hampered by low efficiency of human iCM generation. Here, we established an optimal culture condition by defining a chemically defined media (CDM). In …
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Triglyceride synthesis in normal and hyperapoB fibroblasts
… and HyperapoB patients using cultured skin fibroblasts as an experimental model. In a medium supplemented with lipoprotein-deficient serum, triglyceride synthesis and cholesterol esterification were reduced in the HyperapoB fibroblasts by 40% and 44% respectively as compared to the normal …
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Transdifferentiation of fibroblasts to neural stem cells
The developmental process is carefully controlled by transcriptional and epigenetic changes that occur as a zygote transforms into an adult organism. This process can be reversed by the overexpression of transcription factors Oct4, Sox2, Klf4, and c-Myc, which reprogram a differentiated cell!s …
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Site-Specific Genome Engineering in Mouse Primary Fibroblasts
… several cell types including embryonic and adult fibroblasts, astrocytes and embryonic stem cells. For gene addition, we have demonstrated site-specific insertion of multiple transgenes including human growth hormone and human platelet derived growth factor-B, as well as a surface selectable …
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Site-Specific Genome Engineering in Mouse Primary Fibroblasts
… several cell types including embryonic and adult fibroblasts, astrocytes and embryonic stem cells. For gene addition, we have demonstrated site-specific insertion of multiple transgenes including human growth hormone and human platelet derived growth factor-B, as well as a surface selectable …
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Functional Heterogeneity of Fibroblasts In Dermal Wound Healing
… approaches are critically important. Dermal fibroblasts are critical players in cutaneous wound healing, possibly lending their contractile properties and extracellular matrix (ECM) remodeling functions to promote effective tissue repair. Dermal fibroblasts are also postulated to orchestrate …
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Direct Reprogramming of Fibroblasts into Smooth Muscle Cells
… an attempt to achieve direct differentiation of fibroblasts to specific cell lineages. Human fibroblasts were shortly reprogrammed by overexpression of four reprogramming factors (OCT4, SOX2, KLF4 and c-MYC) and maintained in reprogramming media on a gelatin substrate for four days. These cells …
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Gene expression in synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients Novel expression of IL-19 and IL-22 by fibroblasts
… receptor. This is the first indication that fibroblasts are capable of transcribing this gene. The work presented in this thesis has addressed gene expression in FLS and the findings may prove to be important in understanding maintenance of inflammation in RA. The finding that FLS can …
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Functional Heterogeneity and Metabolic Adaptation of Fibroblasts In Cancer
… in the tumor microenvironment, cancer-associated fibroblasts (CAFs) are a key component in the regulation of tumor development and progression, but their exact functions in tumorigenesis remain poorly understood. This is partly due to the considerable heterogeneity amongst these cells, which …
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The Role of Cancer-Associated Fibroblasts In Lung Tumorigenesis
… microRNA-200 (miR-200) family. Cancer-associated fibroblasts (CAF) enhance tumorgrowth and invasion by secreting VEGF-A that binds to VEGFR1, a processrequired for tumor growth and metastasis in mice and correlated with a poorprognosis in lung adenocarcinoma patients. In this study, we discovered …
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Neurogenesis from Neural Stem Cells, Ependymal Cells and Fibroblasts
… cells in the lateral ventricular wall and fibroblasts. We show that Lnk, a known inhibitor of hematopoietic stem cell self-renewal, is also expressed in the brain. Overexpression or removal of Lnk expression leads to decreased or increased neurogenesis in vitro respectively. When brain is …
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Fibroblasts as matrix modulating cells in asthma and COPD
… the mesenchymal cell phenotypes such as the fibroblasts play a key role. This phenomenon is defined as airway remodeling and is characterized by a deposition of extracellular matrix (ECM) molecules such as collagens and proteoglycans. Importantly, hitherto available studies have only studied …
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Biomolecules that impact phenotypic transitions in fibroblasts and macrophages
<p>Macrophages and fibroblasts are intricately involved in many biological responses. The foreign body response (FBR) is orchestrated by macrophages, wherein the phenotypes of these macrophages exist plastically along a spectrum from M1, proinflammatory macrophages to M2a, anti-inflammatory, …
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Bioenergetic Evaluation of Site-specific Keloid and FKN Fibroblasts
… and the intra- and peri-lesional Keloid patient fibroblasts, normal skin and non-hypertrophic (normo-trophic) scar fibroblasts were used as negative controls. The results show statistically significant and variable growth dynamics with increased proliferation and migration in keloid fibroblasts, …
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