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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"fibroblast growth factor 21"”.
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Metabolic Regulation by Fibroblast Growth Factor 21
Fibroblast growth factor 21 (FGF21) is a secreted hormone that can beneficially regulate glucose and lipid homeostasis. Through a reverse endocrinology approach, we uncovered that FGF21 expression is transcriptionally regulated by the peroxisome proliferator activated-receptor alpha (PPARa) in …
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An investigation of acute exercise and FGF21.
Fibroblast growth factor 21 (FGF21) is a molecule that freely circulates in the blood and helps to regulate metabolism. Interest in FGF21 stems from its ability to promote weight loss and ameliorate type II diabetes in animal models. Recent findings have shown that blood levels of FGF21 increase …
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Jėgos treniruočių įtaka griaučių raumenų ir kraujo uždegiminių rodiklių pokyčiams: sisteminė literatūros apžvalga /
… on increases in brain-derived neurotrophic factor, fibroblast growth factor-21, and insulin-like growth factor-1 levels were found. There was a statistically significant effect of the number of sets on the decrease in interleukin-6 levels. Strength training was found to significantly …
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Exploring neurodegeneration in Ataxia-Telangiectasia
… to mitochondrial DNA depletion in human A-T fibroblasts. In this study, I have identified a cerebellar cognitive affective syndrome in A-T patients with executive and motor language dysfunction. Serum fibroblast growth factor 21 and dentate nuclei hypointensity could serve as potential …
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The Role Of Crebh In Hepatic Energy Regulation Under Metabolic Stress
… regulated by nuclear receptors, transcription factors, and cellular enzymes in response to nutritional, hormonal, and stress signals. Hepatocyte specific, cyclic AMP responsive element-binding protein (CREBH) is a transcription factor that is preferentially expressed in the liver and localized …
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The Physiology and Pharmacology of FGF21 in the Exocrine Pancreas
… with prolonged ISR activation. In the pancreas, fibroblast growth factor 21 (FGF21) is highly expressed, induced by feeding and acts in an autocrine/paracrine fashion. The pancreas also expresses the FGFR1/beta-klotho receptor complex that FGF21 binds to elicit downstream signaling. The …
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The Liver-Derived Endocrine Hormone FGF21 Alters Metabolism and Diurnal Behavior via the Nervous System
… reduce energetically costly activities (growth, reproduction, locomotion). Little is known about the mechanisms that orchestrate and coordinate these physiological and behavioral responses to starvation. The liver-derived endocrine hormone fibroblast growth factor 21 (FGF21) is induced in …
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Non-invasive diagnosis of non-alcoholic fatty liver disease.
… transmembrane 6 superfamily 2 (TM6SF2) and fibroblast growth factor 21 (FGF21) variants as well as a panel of most abundant liver microRNAs. After univariate and multivariate analysis, we confirmed that GG genotype of PNPLA3 exerted a clear role in NASH development, and we identified the …
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Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease
… are lipophilic ligand-dependent transcriptional factors that regulate the expression of specific target genes involved in diverse biological pathways, including development, differentiation, cell proliferation, reproduction and metabolism. FXR is a member of the nuclear receptor superfamily. …
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Regulation of Energy Balance by Dietary Protein
The protein leverage hypothesis posits that protein restriction triggers a compensatory hyperphagia to facilitate the acquirement of the animal's protein needs whereas protein excess elicit hypophagia as the animal's protein requirement is met at a lesser calorie intake. However, the effects of …