Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"fibroblast growth factor 14"”.
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Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels
… of Nav channels as potently as the intracellular fibroblast growth factor 14 (FGF14). FGF14 is a biologically relevant accessory protein of the neuronal Nav channel complex controlling gating, stability, and trafficking of native Nav channels. Through a monomeric interaction with the intracellular …
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Regulation of signaling and function of the voltage-gated sodium channel complex by protein:protein interactions
… PPI between Nav1.6 and its regulatory protein, fibroblast growth factor 14 (FGF14). Using a newly developed assay we screen cellular pathways followed by biophysical validation, we discovered a mechanism by which the JAK2 tyrosine kinase might directly influence neuronal firing through …
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DISRUPTION OF THE HIPPOCAMPAL GABAERGIC SYSTEM IN THE Fgf14 ̶ / ̶ MOUSE MODEL
… that the genetic ablation of the intracellular fibroblast growth factor 14 (FGF14), a molecule required for proper neuronal development, excitability, synaptic plasticity and cognitive function, leads to a reduction in PVIs in the hippocampal CA1 area, accompanied by declined expression of …
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CELLULAR ALTERATIONS OF ADULT HIPPOCAMPAL NEUROGENESIS IN THE FGF14−/− MOUSE MODEL
… have shown that neurogenesis is clearly a multifactorial and complex process that includes proliferation, differentiation, migration, maturation, and integration of newborn neurons in the adult brain circuit. However, a thorough understanding of the molecular and cellular elements at the base of …
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Regulation of the FGF14:Nav Interactome by a GSK-3 Centered Pathway
Psychiatric disorders are complex, multifactorial diseases characterized by disruption of neural circuits, accompanied by an imbalance of excitatory and inhibitory inputs leading to dysregulations in neuronal excitability. Recent research focused on uncovering novel causes of psychiatric disorders …