Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"fibroblast activation protein"”.
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Investigating the fibroblast activation protein alpha expressing stromal cell in a spontaneous murine model of pancreatic adenocarcinoma
… demonstrated that a stromal cell marked by fibroblast activation protein alpha (FAP) mediates local immune suppression in transplantable tumour models. Such models however do not always reflect the biology of human cancer. The following work investigates whether FAP+ cells modulate the …
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Bioenergetic Evaluation of Site-specific Keloid and FKN Fibroblasts
… Owing to reports on an increase in ATP and Fibroblast Activation Protein-1α production in keloids, the aim of this study was to investigate whether the disease phenotypes were linked to bioenergetic changes at a cellular level in these two conditions. Patient-derived tissue biopsies were …
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Finding Common Ground to Treat Primary and Metastatic Cancer: The Potential of Targeting Tumor Stroma
… especially for patients with metastatic disease. Fibroblast activation protein (FAP) is a membrane surface protease found overexpressed in cancer-associated stromal cells. Overexpression of FAP is associated with tumor progression, metastasis and recurrence, and predicts a poorer prognosis in many …
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Elucidating The Role of Cd44 Expression On Mesenchymal Stem Cells Within The Tumor Microenvironment
… and small molecule inhibitor of matrix metalloproteinases. Blocking CD44 signaling through MMP inhibition was characterized by lack of intracellular domain cleavage and lead to the decrease in Twist gene expression. A functional relationship between CD44 and Twist expression was confirmed by …
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Targeting the Tumor Stroma Using a Monoclonal Antibody Platform Technology
… treatment response. Our research shows fibroblast activation protein alpha (FAP) is a relevant target for imaging and treating mCRPC. FAP is emerging as the next pan-cancer target given its upregulated expression in cancer associated fibroblasts (CAFs) and localization to the tumor …
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Blocking Immunosuppressive Factors and Taking Advantage of the Nutrient Supply Within the Tumor Microenvironment: Pathways to Achieve Improved Cancer Immunotherapeutic Efficacy for Patients With Metastatic Melanoma
… MAAs within herpes simplex virus (HSV) glycoprotein D (gD), which blocks the inhibitory BTLA/CD160-HVEM pathway. Compared to a non-gD vaccine, the gD-adjuvanted vaccine enhances CD8+T cells to low avidity epitopes and prolongs survival of tumor-bearing mice. gD renders MAA-specific CD8+TILs …
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Generation and in vivo validation of multi-functional antibody-fusion proteins for cancer therapy
… characterization of three antibody-based fusion proteins for cancer therapy. The first project focused on Tripokin, a multi-specific immunocytokine that combines interleukin 2 (IL2) and tumor necrosis factor (TNF) with the L19 antibody. Tripokin demonstrated enhanced tumor targeting, macroscopic …
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Advancing Technologies for Precision Medicine: From Liquid Biopsy to Single-Molecule DNA Sequencing
… (EpCAM) and mesenchymal cells expressing fibroblast activation protein α (FAPα), were isolated directly from whole blood. Longitudinal monitoring of these CTC subpopulations showed that the ratio of mesenchymal to epithelial CTCs provided an early indicator of treatment response, showing …
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Etablierung und Charakterisierung einer Tetracyclin-induzierbaren PHD2-Knockdown-HeLa-Zelllinie
Prolyl-4-Hydroxylase-Domäne-Proteine 1-3 (PHD1-3) sind sauerstoffabhängige Enzyme, die den Hypoxie-induzierbaren Faktor (HIF-1α) hydroxylieren und damit für den Abbau markieren. HIF-1 ist ein Transkriptionsfaktor, der die Expression von mehr als 70 Genen reguliert, die im weitesten Sinne für die …
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Tumour infiltrating T cells in non-small cell lung cancer and their interactions with cancer-associated fibroblasts
… and therapeutic approaches. Cancer associated fibroblasts (CAFs) are the most abundant stromal cells of the tumour microenvironment (TME) and dampen the cytotoxic T cell (CTL) response in other solid tumours. Recently, CD39 has emerged as a marker to identify tumour relevant T cells and CD39 …
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Funktionelle Untersuchungen zum Einfluss von FAP-Inhibitoren auf die Tumorzellmigration und Invasion
Das Fibroblasten-Aktivierungs-Protein (FAP) ist eine Oberflaechenprotease mit kollagenolytischer Aktivität in vitro, die in vivo spezifisch von Fibroblasten in der Umgebung maligner epithelialer Tumoren in der Phase der Invasion und Disseminierung aufreguliert wird. Da Matrixproteasen durch …
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Generation of Glioblastoma specific SNAP based antibody fusion proteins for future radiolabelling application
… overexpressed in GBM: (i) the transmembrane protein epidermal growth factor receptor (EGFR), which is associated with tumour cell proliferation, and (ii) Fibroblast Activation Protein alpha (FAPα), an active protease in the stromal tissue of the GBM tumour microenvironment. SNAP-tag® fusion …