Global ETD Search
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Showing 1 to 10 of 10 for “"fibrinolytic activity"”.
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Fibrinolysis by bile
… Whatman DE 32 produced four areas, or Peaks, of fibrinolytic activity of cholelysin, each with some differing characteristics against the various substrates. These complexities were not studied in detail, and a simplification of the procedure was discovered, using batch-wise elution with tris …
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Cerebral Amyloid Angiopathy-Causing Beta-Amyloid Variants Have Altered Effects on the Clotting System
… of the known WT Aβ enhancements to proteolytic/fibrinolytic system activation, I examined the effects of HCAA Aβ on the fibrinolytic system. I found that the majority of HCAA Aβ variants led to increased tPA-mediated plasminogen activation. The HCAA Arctic variant (E22G) did not, which may …
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The potential role of innate immunity in the pathogenesis of post-operative adhesions
… Substances released from these cells regulate fibrinolytic activity, tissue remodeling, angiogenesis, and extracellular matrix turnover, processes that are known to be central to the development of adhesions. Our long-term goal is to prevent or selectively limit the development of …
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Proteases of the neutrophil membrane represent an alternative fibrinolytic pathway to that mediated by plasmin
… inhibit neutrophil membrane-dependent fibrinolytic activity. Upregulation of enzyme activity occurred following association of fibrin substrate with the cell membrane and was dependent on the activation of cellular kinases, in particular protein kinase C. Fibrin products generated by …
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The influence of carrageenans on the cells and pathways of haemostasis and their role in immunosuppression
… suggest that carrageenan is able to inhibit the activity of Factor XII, Factor I and thrombin. Unlike the known activities of the anticoagulant heparin, carrageenan activity was noted in the absence and presence of antithrombin III. The efficacy of carrageenan fractions to exert their particular …
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Advancing sepsis treatment: synthesis and evaluation of multi-target drugs with antimicrobial, antioxidant and anticoagulant properties.
… hours at a dosage of twice the MIC. Antioxidant activity was investigated using Ferric Reducing Antioxidant Power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays, with all compounds showing antioxidant activity. JW6, JW7 and JW10 demonstrated strong activity in the DPPH assay, with lead …
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Cloning and targeted deletion of the mouse histidine rich glycoprotein gene and functional characterization of HRG in mice
… blood coagulation and fibrinolysis. Antithrombin activity in plasma of Hrg-/- mice was higher than in plasma of heterozygous Hrg+/- or wild-type Hrg+/+ mice in the presence of a fixed amount of heparin. The prothrombin time was shorter in Hrg-/- mice than in Hrg+/- and Hrg+/+ mice. Bleeding time …
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Effects of air pollution on vascular thrombosis
… cells, thus inhibiting the endogenous fibrinolytic mechanisms that promote thrombus breakdown. The initial aims of this work were to develop an in vivo model of thrombosis, to determine whether exposure to DEP did alter clotting. Initial attempts to develop the Folts’ model (which …
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The detection of occult metastatic disease in patients with cutaneous melanoma
… whether high or low plasma levels and/or activity of plasminogen activator inhibitor type 1 (PAI1) correlate with the presence of metastatic disease in patients with melanoma. PAI1 is considered to be the main regulator of fibrinolytic activity in blood and has been identified as a key …
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Thyroid hormonal axis as a significant regulator of haemostasis // Тироидната хормонална ос - значим регулатор на хемостазата
Дисертационният труд е посветен на актуален за медицинската теория и практика проблем. Проучва се влиянието на хормоните на тироидната ос - TRH (Thyrotropin releasing hormone), TSH (Thyroid stimulating hormone), T3 (Trijodthyroninum) и Т4 (Thyroxin) върху хемостазата у плъхове. Използвани са 1027 …