Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"fibrin gel"”.
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Ex-vivo-Expansion perikardialer Patchstrukturen : zur Frage des Einflusses von zyklischem Stress und laminaren Strömungsbedingungen auf das Ex-vivo-Remodelling perikardialer Patchstrukturen
… concerning active migration and proliferation in fibrin gel scaffolds should be investigated. METHODS: Perforated porcine pericardial patches filled up with a fibrin-cell-carrier were cultivated in custom-designed bioreactor systems up to 20 days, one group under cyclic stress conditions observing …
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Studying the Efficacy of an Injectable 3-Dimensional Fibrin Extracellular Matrix to Characterize the Effects of Antitumor Agents on SW620 Cells in a Microfluidic Device
… tumor culture that was seeded on top of a fibrin extracellular matrix (ECM) gel to determine how the tumor cells would respond to the 5-luorouracil treatments while growing on the fibrin. The third experiment was to create a 3-dimensional tumor culture that was seeded inside the fibrin ECM …
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Development of a Tubular Biological Tissue-Engineered Heart Valve with Growth Potential
… fabricated by entrapping dermal fibroblasts in a fibrin gel and allowing them to replace it with circumferentially-aligned extracellular matrix. Following in vitro culture, the engineered tubes possessed physiological strength and were decellularized to increase their shelf-life and reduce their …
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Fibrin targeting microbubbles for the detection of nascent surgical adhesions
… adhesions. This thesis examines the use of fibrin-targeting microbubbles as an ultrasound contrast agent to diagnose peritoneal adhesions. Fibrin targeting is achieved by integrating a CREKA (Cys-Arg-Glu-Lys-Ala) peptide into the microbubble shell. The properties of targeted and non-targeted …
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Pädiatrische tissue engineerte Herzklappen auf Basis einer Fibringelmatrix : Optimierung des Herstellungs- und Konditionierungsprozesses
… so far to valvular tissue engineering based on a fibrin gel to the needs of pediatric heart valves. This adaptation to the synthesis of tissue engineered heart valves in a reproducible quality was conducted in three work packages: (1) The readjustment of the 3D mould geometry to the miniaturized …
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IN-VITRO VASCULARIZED TISSUE EQUIVALENTS FROM HUMAN EMBRYONIC STEM CELL-DERIVED ENDOTHELIAL AND VASCULAR SMOOTH MUSCLE CELLS
… arterial ECs and vSMCs in a polyethylene-glycol-fibrin gel under serum-free conditions. Upon the 3D co-culture, the arterial ECs and vSMCs self-organize and mature into a microvascular network to form in-vitro VTE. In summary, we demonstrate the efficient differentiation of hESCs to ECs (arterial …
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Using electrical stimulation responses to understand cochlear implant status
… on a CI in which I culture fibroblasts in a fibrin gel wrapped around a CI electrode array. CIs are known to cause fibrosis formation intracochlearly, which can lead to residual hearing loss. I show that complex impedance can be used to track fibrosis formation over time by measuring …
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In vitro modelling of human glioblastoma migration and angiogenesis
… GBM/HUVECs spheroids in HDF containing fibrin gel. Co-culturing HUVECs with HDF lead to HUVECs undergoing an angiogenic-like response, sprouting radially outwards forming capillaries. Primary, stem-like cell rich, GBM cells were found to integrate with the capillaries. Their presence …
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Delayed Thrombus Resolution and Fibroproliferative Vascular Wound Healing From Deficiency of Type Iii Collagen: A Paradoxical Mechanism For Tissue Fragility
… mutations were seeded into three-dimensional fibrin gel constructs and stimulated with transforming growth factor-β1 to initiate myofibroblast differentiation. Although early signaling events occur similarly in all cell lines, late extracellular matrix- and mechanically-regulated events like …
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Sustained hydrogel-based delivery of RNA interference nanocomplexes for gene knockdown
… and injectable scaffolds such as hydrogels. Various scaffolds have been shown to aid in sustained localised delivery of RNAi molecules and improve gene silencing. This research focused on optimising and establishing such an RNAi hydrogel-siRNA-nanoparticle (hydrogel-nanocomplex) system …
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Fibringel als Scaffold für das Tissue Engineering von Herzklappen
… goal was to optimize the molding technique for fibrin-based heart valves first described by Jockenhoevel et al. and to develop a bioreactor system for in-vitro culture of fibrin-based tissue engineered heart valves. The molding technique was simplified to allow for routine use and a bioreactor …