Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"fibril polymorphism"”.
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Automated protein NMR data analysis and its application to a-synuclein fibrils
… to the problems of refining an a-synuclein fibril structure with proton-detected NMR data, the analysis and characterization of a pair of interrelated a-synuclein fibril strains with distinct pathological properties, and to the general question of fibril polymorphism, a phenomenon that …
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Amyloid fibril structure of peptides and proteins by magic angle spinning NMR spectroscopy and dynamic nuclear polarization
Amyloid fibrils are insoluble, non-crystalline protein filaments associated with a number of diseases such as Alzheimer's and Type Il diabetes. They can have a functional role in different organisms and many proteins and peptides have been found to form amyloid fibrils in vitro. We have used magic …
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Structural Elucidation of [RNQ+] prions Transmissible Infectivity
… of the structure and toxicity of yeast fibrils formed in vivo, while correlating them to what is observed in vitro.</p><p>I looked to investigate the fibril polymorphism of aggregates and prions associated with prion disease by using yeast prions as a mode of toxicity and propagation. …
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Structural Polymorphism of Alpha-Synuclein in Conditions Resembling the Cellular Environment
… from its functional disordered form into amyloid fibrils with characteristic β-sheet structure, as being at the centre of PD. However, many unanswered questions remain with regards to the aSyn aggregation mechanism in neurons and, in particular, the earliest steps of this process, when the …