Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 170 for “"fibril"”.
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Amyloid Fibril Nucleation In Reverse Micelles
… a conformational change and aggregates into fibrils. These fibrils then coalesce into amyloid plaques, which are the pathognomonic brain lesions of Alzheimer‘s disease. The plaques are centers of active oxidative stress and neuronal death, so the conditions under which fibrils form is of high …
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Amyloid fibril formation in Alzheimer's disease
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1993.
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DESIGNER COLLAGEN-FIBRIL BIOGRAFT MATERIALS FOR TUNABLE MOLECULAR DELIVERY
One of the biggest challenges in tissue engineering currently is the formation of a functional microvascular network as part of an engineered tissue graft. Despite many advances in tissue engineering methods, the field still awaits biograft designs that enable neovascularization at clinically …
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Solid-state NMR studies of α-synuclein fibril structure
… α-synuclein (α- syn), adopts an amyloidogenic fibrillar form in Lewy bodies. In recent years research has slowly started to unravel clear pathological links between this fibrillar protein and PD disease progression. While great progress is being made, it has become evident that the structures …
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Applications of EPR with an Emphasis on Tau Fibril Structure
… as a powerful technique for the study of amyloid fibrils, a class of protein aggregates implicated in a number of neurodegenerative disorders. Microtubule-associated protein tau forms fibrils linked to Alzheimerfs disease through seeded conversion of monomer. Self-assembly is mediated by the …
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Chemical modifications of insulin and their relation to fibril formation.
Massachusetts Institute of Technology. Dept. of Biology. Thesis. 1945. M.S.
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pH MODULATION OF FIBRIL DISSOCIATION AND COPPER BINDING PROPERTIES OF THE PRION PROTEIN
… its "scrapie" conformer (PrP<sup>Sc</sup>, the fibrillar form) constitutes the key event of the etiology of prion diseases. Fibril dissociation is necessary for efficient conversion and continued propagation of the disease state. Recent studies have revealed that conversion occurs along the …
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pH MODULATION OF FIBRIL DISSOCIATION AND COPPER BINDING PROPERTIES OF THE PRION PROTEIN
… its "scrapie" conformer (PrP<sup>Sc</sup>, the fibrillar form) constitutes the key event of the etiology of prion diseases. Fibril dissociation is necessary for efficient conversion and continued propagation of the disease state. Recent studies have revealed that conversion occurs along the …
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Investigating the process of fibril formation of the Iowa mutant of the Alzheimer's peptide
… Alzheimer’s disease, has been shown to undergo a fibrillization process that involves numerous intermediate stages. One of the intermediate stages has revealed a high neurotoxicity and is believed to be the cause of neurodegeneration associated with Alzheimer’s disease. Various point mutations of …
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Amyloid fibril structure of peptides and proteins by magic angle spinning NMR spectroscopy and dynamic nuclear polarization
Amyloid fibrils are insoluble, non-crystalline protein filaments associated with a number of diseases such as Alzheimer's and Type Il diabetes. They can have a functional role in different organisms and many proteins and peptides have been found to form amyloid fibrils in vitro. We have used magic …
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Study of Structural and Physical Properties of Small Molecule and Nanoparticle Inhibitors of Amyloid-B Protein Fibril Formation In Alzheimer'S Disease
<p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia in the elderly. The instances of AD are rapidly increasing and there is no cure currently available for this devastating disease. Current therapies for the disease allow AD patients to delay or …
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Conformational studies of the beta amyloid protein and in vitro models for the effects of apolipoprotein E on fibril formation in Alzheimer's disease
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Solid-State Nuclear Magnetic Resonance Spectroscopy of Alpha-Synuclein Fibrils
… towards solving 3D structures of amyloid fibrils. Alpha-synuclein is a 140-residue protein that has been implicated in Parkinson's disease. Fibrils of alpha-synuclein are the primary fibrillar component of Lewy bodies, which are the pathological hallmark of the disease; however, the role …
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Investigating the self-assembly and molecular chaperone ability of casein proteins and polyproline
… is their propensity to assemble into amyloid fibrils, which are associated with many age-related diseases. Based on the stability of their predicted 'steric zipper' structures, which form the backbone of amyloid fibrils, caseins from all species contain amyloidogenic sequences. Such sequences …
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Investigating the self-assembly and molecular chaperone ability of casein proteins and polyproline
… is their propensity to assemble into amyloid fibrils, which are associated with many age-related diseases. Based on the stability of their predicted 'steric zipper' structures, which form the backbone of amyloid fibrils, caseins from all species contain amyloidogenic sequences. Such sequences …
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Computational Prediction of the Agregated Structure of Denatured Lysozyme
… conditions where heat denatured lysozyme formed fibril structures that were observed to be 8-17 nanometers in diameter under the electron microscope. Even though the crystal structure of lysozyme is known, the denatured form of this protein is still unknown. Therefore, we used Rosetta++ protein …
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Growth and Toxicity of Amyloid β Polymorphs
… soluble aggregates or insoluble β-sheet-rich fibrils and plaques in the brain. Limited success in targeting these fibrils and plaques stems from a lack of understanding of the intricate process of Aβ fibrillization. We investigated the unknown mechanism of action of a potential Alzheimer’s …
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Tau Aggregation, Conformational Selection, and Inhibition
<p>Tau fibrils are a pathological hallmark of over 20 neurodegenerative disorders, including Alzheimer's disease. There currently is no cure for these diseases and treatments are limited. Once Tau fibrils form in the brain, they propagate down neuronal networks, and this spreading is linked to …
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