Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"fgf8"”.
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Signaling mechanisms and developmental function of fibroblast growth factor receptors in zebrafish
… of vertebrates (Itoh 2007). Some Fgfs, such as Fgf8, are locally secreted and signal over a long range to provide positional information in the target tissue (Scholpp and Brand 2004). Fgf ligands signal in a receptor-dependent manner via tyrosine kinase receptors, four of which have been so far …
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Collective Behavior of Drosophila Melanogaster Neural Progenitor and Imaginal Disc Cells within Controlled Microenvironments
… to gradients of fibroblast growth factor 8 (FGF8), while single cells demonstrated chemokinesis, non- directed cell migration within the μLane. A microfluidic system called the Micro Optic Stalk (μOS), that recapitulated in vivo geometric constraints seen during Drosophila retinal …
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FGF signaling in Xenopus laevis lens regeneration
… The described experiments found that FGF1, FGF8, and FGF9 mRNA are more expressed in the retina than the cornea, indicating that they may be the signal for inducing lens regeneration. Three receptor mRNAs (FGFR1, FGFR2, and FGFR3) were found to be expressed in the cornea. Second, the …
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Limbs gone batty : the role of the anterior-posterior patterning signal, Sonic Hedgehog, in the development of the unique bat limb
… is in line with the reported expansion of Fgf8 expression in the AER (Cretekos et al. 2007) and reveals that an enhancement of the Shh-Fgf positive feedback loop may be responsible for the initial posterior expansion of the bat forelimb. Later in development (stage 16) Shh and PtcJ acquire …
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Temporal and spatial controls of cell fate specification in the cerebellum
… I also demonstrate the role of the isthmic gene, Fgf8, in the maintenance of the expanded domain through in ovo electroporation of plasmids encoding Fgf8 and a dominant-negative FGF receptor. This FGF-dependent domain of Atoh1 is regulated independently from the specification of rhombic lip …
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Identification and characterisation of novel zebrafish brain development mutants obtained by large-scale forward mutagenesis screening
… analysis of the expression patterns of lim1 and fgf8, genes functioning as early neuronal markers and as a patterning gene, respectively. Three of these mutants lacked an MHB, and by complementation studies, I identified these mutants as being defective in the spg locus. The second screen …
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A genetic analysis of somitogenesis in the Medaka (Oryzias latipes)
… MHB defects were described in the zebrafish fgf8 mutant acerebellar (ace). In ace zebrafish mutant, somites were only slightly defective, although FGF signaling has been shown to be important for somite formation in chicken, mouse and zebrafish. This was explained by functional redundancy …
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Zebrafish Cardiac Development Requires a Conserved Secondary Heart Field
… in teleosts, as Nkx2.5 and Nkx2.7 as well as Fgf8 regulate Bmp signaling in the zebrafish heart fields. Additionally, the transcription factor Tbx1 and the Sonic hedgehog pathway are necessary for normal development of the zebrafish arterial pole.</p>
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The Misexpression of Sonic Hedgehog Leads to Digit Duplication
… using in-situ hybridization with probes for Fgf8, Fgf10 and Shh. Taken together, morphological and molecular expression analysis data supports our hypothesis that mis-expression of Shh leads to digit duplication defects.
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Mechanism of cell adhesion at the midbrain-hindbrain neural plate in the teleost Danio rerio
… by the expression and subsequent release of FGF8. False patterning events of this region in early developmental stages would therefore display dramatic results over time. As it has been shown that the midbrain-hindbrain boundary (mhb) in the zebrafish is a compartment (or lineage restriction) …
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Regulation of morphogen signalling during neural patterning in the Xenopus embryo
… of xHtrA1, and xHtrA1 stimulates FGF4 and FGF8 gene activities, allowing positive feedback regulation. We also show that xHtrA1 triggers proteolytic cleavage of xBiglycan, xSyndecan-4, and xGlypican-4, suggesting a model, in which xHtrA1 through cleaving proteoglycans releases …
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The role of pou2/spiel-ohne-grenzen (spg) in brain and endoderm development of the zebrafish, Danio rerio
… I demonstrate that pou2 synergizes with Fgf8 signaling in order to activate particularly the hindbrain primordium. Since pou2 is already provided to the embryo by the mother, I generated embryos which lack maternal and zygotic pou2 function (MZspg) to reveal a possible earlier than …
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Cross-species microarray analysis of limb development in the bat, Miniopterus natalensis
… in bat limb development (Hoxd13, Bmp2, Fgf8 and Prrxl), higher mRNA transcript levels in the CS 17 bat hand plate relative to the mouse hand plate was found for Hoxd13 (FC = 2.6) and Prrxl (FC = 1.8). These differences were also found in a comparison to the CS 17 bat foot plate (Hoxd13: …
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Transcriptional profile of c-kit positive cardiac stem-progenitor cells (c-kitpos eCSCs) isolated from the four chambers of the adult human heart
… Hand1, Hand2, Pitx2, Tbx5, Tbx20, Hrt1, Hrt2, Fgf8, Fgf10, and Isl1 were found at differential levels in c-kitpos CSCs isolated from the four cardiac chambers. Conclusion: This study is the first to show that c-kitpos eCSCs derived from human adult cardiac samples, do not appear to have a …
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Defining The Molecular Networks Necessary For Thymus Fate and Organogenesis
… consistent with the dual hypothesis that <em>Fgf8</em> expression in the ventral 3<sup>rd</sup> pp promotes thymus fate by restricting TBX1. Based on these results, we generated a working model describing the signaling networks that contribute to thymus fate and 3<sup>rd</sup> pp …
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Genexpression während der Zahnentwicklung der Maus (Mus musculus)
… by ectodermal signals. An early signal (Fgf8) comes from the oral epithelium and induces the development of the lower jaw. Molar morphogenesis in the maxillary starts from the mesenchyme, influenced by genes like Barx1, Dlx2 and Dlx2. At the same time the absence of genes like Msx1 and …
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Limb cell behaviors in Monodelphis domestica growth and development: the effects of Fgf pathway activators and inhibitors
A fundamental question in biology is, “how is growth differentially regulated during development to produce organs of particular sizes?” Research in invertebrates has shown that answers to this question can be gained by studying how serially homologous organs of a single animal (e.g., Drosophila …