Global ETD Search
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Showing 1 to 20 of 36 for “"fetal growth restriction"”.
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Perinatal outcomes with fetal growth restriction according to hypertensive disorder in pregnancy
태아 발육 부전이 의심되는 환자에 있어 산전 진찰의 목적은 실제 성장 부전을 일으킬 수 있는 위험인자를 가진 산모들을 조기에 발견하고 산과적 중재를 통하여 신생아의 이환률과 사망률을 줄이는데 있다. 발육부전을 동반한 임신은 다양한 산과적 문제들이 합병되어 있는 경우가 많으며 병태 생리학적으로 전자간증 및 만성 고혈압 등의 고혈압성 질환과도 연관이 있다고 밝혀진바 있다. 하지만 발육부전과 임신성 고혈압 질환이 같이 있는 경우 각 질환의 유형에 따른 주산기 예후에 대한 예후를 직접적 비교 연구는 많지 않다. 본 논문에서는 태아 …
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Unsupervised Multi-Scale Analysis for the Identification of Placental Subtypes of Human Preeclampsia and Fetal Growth Restriction
Preeclampsia (PE) and fetal growth restriction (FGR) are two of the most common pathologies of pregnancy, both thought to be primarily driven by placental dysfunction. Despite decades of research into the underlying etiologies of these disorders, as well as potential biomarkers and treatments, no …
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Automated Detection of Maternal Vascular Malperfusion Lesions in Human Placentas Diagnosed with Preeclampsia and Fetal Growth Restriction Using Machine Learning
Introduction: Preeclampsia (PE) and fetal growth restriction (FGR) are common obstetrical complications, often with pathological features of maternal vascular malperfusion (MVM) in the placenta. Current placental clinical pathology methods involve a manual visual examination of histology sections, …
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Prediction and prevention of fetal growth restriction and compromise of fetal wellbeing: systematic reviews and meta-analyses with model based economic evaluation.
Restriction of fetal growth and compromise of its wellbeing remain significant causes of perinatal death and childhood disability. There is a lack of scientific consensus about the best strategies for predicting these conditions before birth and thus there is uncertainty about the best management …
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Impact of fetal growth discordance and selective fetal growth restriction on perinatal outcomes in dichorionic diamniotic twins: A systematic review and meta-analysis
Σκοπός: Η διερεύνηση της επίδρασης της ασυμφωνίας εμβρυϊκής ανάπτυξης και του εκλεκτικού περιορισμού της εμβρυϊκής ανάπτυξης (sFGR) στην περιγεννητική έκβαση σε δίδυμες κυήσεις διχοριακές διαμνιακές (DCDA). Μέθοδοι: Πραγματοποιήθηκε συστηματική ανασκόπηση και μετα-ανάλυση με χρήση των βάσεων …
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Preeclampsia Link to Gestational Hypoxia
… and adverse effects on the offspring include fetal growth restriction, which is not only a major driver of perinatal morbidity, but also increases cardiometabolic risk in later life. In this thesis, we used bespoke isobaric chambers to induce hypoxia in sheep for the last third of pregnancy …
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Pareto Task Inference Analysis of Single-Cell RNASequencing of Human Placenta Reveals Biological Insightsinto Adverse Pregnancy Outcomes
… pregnancy outcomes (APOs), such as preeclampsia, fetal growth restriction, and preterm birth, occur in 10-15% of pregnancies. There is limited knowledge of how the cellular states in the placenta and decidua tissues are altered in women with particular APOs or may contribute to APOs. Single-cell …
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Intrauterine effects of maternal weight dynamics
… hypothesised to play an aetiological role in fetal growth restriction and the development of preeclampsia. This thesis aims to investigate the association between maternal weight dynamics and both cardiovascular adaptation to pregnancy and related perinatal outcomes. First, a meta-analysis was …
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Maternal Cardiac Autonomic Function and Fetal Behaviour in Hypertensive and Obese Pregnancies
… is associated with placental insufficiency and fetal growth restriction, whereas obesity in pregnancy is associated with placental inflammation and macrosomia. Fetal growth restriction is associated with an increased risk for language deficits at 2-5 years of age. However, maternal cardiac …
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Early life origins of the insulin resistance syndrome in the aged guinea pig.
In human populations, perturbed growth in early life and ageing have been identified as risk factors for the development of Insulin resistance syndrome (IRS). The consequences of restricted prenatal growth on postnatal function have been investigated using numerous experimental models of …
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Serotonin Reuptake Inhibitor Use During Pregnancy: Perinatal Outcomes
… differences in rates of prematurity (4% vs. 7%), fetal growth restriction (6% vs. 2%), transfer to a higher nursery for NBS (11% vs. 10%), respiratory abnormality (7% vs. 5%), or hospitalization duration among infants with NBS findings (2 vs. 6 days). CONCLUSIONS: Findings of NBS were identified …
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Tissue- specific DNA methylation profiles in newborns
… and epidemiological studies demonstrate that fetal growth restriction and low birth weight enhance the risk of chronic diseases in adulthood. Derangements in tissue-specific epigenetic programming of fetal and placental tissues are a suggested mechanism of which DNA methylation is best …
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Pregnancy outcomes in females with hidradenitis suppurativa
… severe maternal morbidity, preeclampsia, fetal growth restriction, gestational diabetes, and gestational hypertension. These measures were compared using Chi-square and Breslow-Day. No evidence suggested the rates observed in the datamart were substantially different from national figures. …
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Risk of Expectant Management and Optimal Timing of Delivery in Low-risk Term Pregnancies: A Population-based Study
… anomalies, diabetes, hypertension, and fetal growth restriction were excluded. Composite outcomes and individual maternal complications, stillbirth rates, neonatal complications and infant death rates were compared among cases that underwent expectant management vs. deliveries that …
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Chronic Gestational Inflammation: Comparisons of Obesity-Mediated and Preeclampsia-Mediated Placental Inflammation using Transcriptomic and Histological Methods
… at embryonic day 18.5, with assessments of fetal and placental weights. Placentas were then collected and processed for detailed histomorphometry and transcriptomic analyses. Placenta transcriptomics data underwent differential gene expression analysis using DESeq2. Ranked gene set …
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Recapitulation of Human Placental Insufficiency in a Novel Mouse Model :New Paradigm in Translational Research
… branch ligation (MUAL) reliably resulting in fetal growth restriction (FGR).Methods: At 18 days, timed mated C57BL/6J dams were divided into two groups: MUAL(n=18) ; and control-sham operated (n=18) with uterine horn fetal positions matched to each MUAL fetus. Pups were delivered on day 20, …
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The Role of Apolipoprotein E in Pregnancy-Associated Protein Misfolding and Risk of Preeclampsia
… responsible for >70,000 maternal and 500,000 fetal deaths annually. Currently, there is no cure for preeclampsia, apart from the emergent delivery of the fetus and the placenta. Although several pathophysiologic processes are implicated, our understanding of preeclampsia causation remains …
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The Effect of Aberrant Inflammation During Pregnancy on Subsequent Risk of Maternal Metabolic Disease Development
… results in development of metabolic disease in growth restricted offspring. To study maternal metabolic disease development, bacterial lipopolysaccharide (LPS) was administered to induce inflammation to pregnant mice on gestational day (GD) 10.5, resulting in total fetal loss. Starting on GD …
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Effect of Inflammation in Pregnancy on Maternal and Offspring Cardiovascular Systems
… utilized rodent models of pregnancy loss and fetal growth restriction to assess the effects of aberrant inflammation during pregnancy and subsequent high fat diet consumption on cardiac function, morphology, and biomarkers of CVD in mothers and offspring. In the maternal study, pregnant …
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A prospective study of implantation, maternal cardiovascular function and pregnancy outcome
… implantation, ultrasound measurements of fetal size and cardiovascular changes during pregnancy. The secondary objective was to investigate ovulation and implantation timing using digital home ovulation and pregnancy test kits along with cardiovascular changes in relation to various …
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