Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"ferroportin"”.
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Misregulation of Iron Handling Proteins in Excitotoxic Brain Injury
… Increased expression of the iron transporters, ferroportin-1 and ceruloplasmin was also observed after kainate injection. The misregulation of iron handling proteins would lead to abnormally high iron accumulation in kainate lesioned hippocampus, which generate reactive oxidative stress and …
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The effects of quercetin on iron metabolism
… decrease in basolateral transport genes ferroportin (FPN) and hephaestin expression suggesting polyphenols may have direct gene regulatory effects. Exploring the cellular mechanisms underlying quercetin-induced FPN down-regulation, transfection of 5’FPN promoter constructs showed …
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Restored iron transport by a small molecule promotes absorption and hemoglobinization: discovery, development, and mechanistic studies
… of iron out of J774 macrophages deficient in ferroportin. The same compound promotes gut iron absorption in DMT1-deficient rats and ferroportin-deficient mice, as well as hemoglobinization in DMT1- and mitoferrin-deficient zebrafish. These findings illuminate a general mechanistic framework …
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Hinokitiol restores hemoglobinization and mitigates neurodegeneration in animals by re-establishing iron homeostasis
… and iron deficiency in various sites due to ferroportin (FPN1) dysfunction. Genetic FPN1 deficiency causes Ferroportin disease (FD), which is characterized by iron deposition in liver macrophages and anemia. Aside from loss-of-function genetic mutations, FPN1 deficiency can be induced by …
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Identification of Chlamydial Iron-Responsive Proteins during Intracellular Growth.
… line with inducible expression of recombinant ferroportin, a eukaryotic iron efflux protein, was examined. Lastly, 10 chlamydial proteins differentially expressed during growth in iron-restricted host cells were identified by proteomic analysis of radiolabeled proteins followed by mass …
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Resistance to HER2-targeted therapies in HER2-positive breast cancer
… increased heme oxygenase-1 (HO-1), iron exporter ferroportin and altered iron storage. To ascertain if modulation of dietary iron intake could affect the development of resistance to sapatinib, mice were given a control or iron-deficient diet and treated with vehicle or sapatinib. This showed that …
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Comparison of expression pattern and localization of iron transport proteins in rat liver, brain and spleen during acute phase response:invivo and invitro studies
… divalenten Metallions transpoter-1 (DMT-1) und Ferroportin-1 (FPN-1) in Ratten Leber, Gehirn und Milz während der Akutphase-Antwort auf experimentelle Gewebeschädigung. Schädigung der Muskulatur wurde durch Injektion von Terpentinöl (TO) in Hinterbeine von Ratten und Mäusen (Wildtyp und …