Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 46 for “"female offspring"”.
-
Maternal High Fat Feeding: Impact of Female Offspring Body Composition and Bone Health
… body composition and weakens bones. Whether female offspring of mothers consuming a HFD are similarly affected at weaning and early adulthood is unclear. This research determined whether maternal HFD contributes to long-lasting alterations in body composition and bone health of female …
-
Variation in postpartum maternal care programs the development of neuroendocrine and mesolimbic dopamine pathways in female offspring
… licking and grooming (LG) in infancy, such that females that experience high levels of LG (High LG) during postnatal development typically themselves become High LG dams, and females that experience low levels of LG become Low LG dams. Experience of high maternal LG also predicts elevated …
-
A maternal low-protein diet during gestation induces hepatic autophagy gene expression only in the female offspring Sprague-Dawley rats
… related-gene expression in the liver of offspring rats. In this study, pregnant Sprague-Dawley rats were fed either a control diet (18% energy from protein) or a low-protein diet (8.5% energy from protein) during gestation period followed by the control diet during lactation. Offspring …
-
Maternal High-Salt Diet During Pregnancy in Sprague Dawley Rats Programs Exaggerated Stress-Induced Blood Pressure and Heart Rate Responses in Adult Female Offspring
… high salt (HS) diet throughout pregnancy. Adult offspring were fitted with radiotelemetry probes to continuously measure blood pressure and heart rate. Rats were placed in restraining cages to test for a programmed acute stress hyperresponsiveness. Offspring were challenged with HS diet for one …
-
The effect of metformin intervention on the programming of cardiometabolic health in offspring of obese pregnancy
… metabolic and cardiovascular disease in the offspring. Clinically relevant interventions are required to break the transgenerational cycle of obesity. Metformin is used to treat GDM in the UK and RCTs are investigating metformin as a candidate for implementation in pregnancies complicated by …
-
Prenatal and postnatal nutritional influences on leptin sensitivity and susceptibility to diet-induced obesity in the rat
… induce prenatal undernutrition in experimental offspring. To investigate the interaction between prenatal nutrition and postnatal diet, and its effects on obesity development, female offspring were placed on three different diets: standard chow, a high fat diet or a calorie restricted diet. The …
-
Mother-Offspring Relationships in Tibetan Macaques (<i>Macaca thibetana</i>) at Mt. Huangshan, China
<p>The mammalian mother-offspring relationship, the first bond an offspring will form, is complex in its development, as well as its costs and benefits to both mother and offspring. Across various non-human primate species, researchers have extensively examined this relationship, yet very little is …
-
Microbial and Immune Signatures of Stress and Antidepressants Across Sex and Generations
… distinct microbial alterations in males and females, with males showing a greater magnitude and diversity of microbial alterations. We further observed that female offspring more closely mirrored the microbial community structure of their dams, and that perinatal citalopram treatment produced …
-
An investigation into whether an exercise intervention during pregnancy can prevent the programming of cardiovascular disease in the offspring of obese mothers
… Previous data using this model showed that male offspring born to obese dams have pathological cardiac hypertrophy and ex vivo cardiac dysfunction. A second aim of this thesis was to establish if exercise intervention in obese dams was protective to the cardiovascular health of the offspring. …
-
Neurodevelopmental and Behavioral Consequences of Serotonin System Disruption via Early Life Exposure to SSRI Antidepressants
… long-term impact of these medications on exposed offspring are poorly understood. Perinatal SSRI exposure alters human offspring's neurodevelopment and increases risk for psychiatric illness in later life. Rodent studies suggest that perinatal SSRI-induced behavioral abnormalities are driven by …
-
Prenatal PolyI:C induced schizophrenia-like cognitive inflexibilities in the male, but not female, rat adult offspring
… to develop psychiatric disorders in the adult offspring. One study found that schizophrenic patients pre-exposed to a prenatal infection perseverated more during the WCST, than non-pre-exposed patients. Despite these findings, there are still numerous limitations (e.g., ethical concerns) when …
-
Do females counter against costly males in the degu, Octodon degus?
Sexual conflict over reproduction may result in females incurring reproductive costs from males. Females may counter against costly males through social support from cohesive relationships with other females. In plural breeders, social support may promote communal offspring care, improving the …
-
The effects of dietary protein intake by the dam and by the offspring on mammary gland development in young female rats
… on mammary gland development in first generation female Sprague Dawley rats. Offspring were fed the same diet as fed to their dams during gestation and lactation, or offspring were crossed over at weaning to different protein intakes, from control dams fed 16% casein during lactation and …
-
The effect of maternal nutrition on offspring gene regulation via epigenetic modulation
… that results in persistent alteration of the offspring epigenome and associates with health outcome later in life. Both DNA methylation and histone modifications have been reported in a range of rat tissues including liver, kidney, skeletal muscle and adrenal gland following a restricted diet …
-
The effects of leptin on placental development and function, and offspring behavior in mice
… the effect of maternal hyperleptinemia on offspring behavior. We compared wildtype offspring from two hyperleptinemic mouse models. Adult offspring from hyperleptinemic dams weighed less, and were more active than their controls. Female offspring from these dams consumed more food and had …
-
Aberrant segregation in human populations
… age was very highly significant (for pooled offspring of A1B and A2B fathers). The sex ratio changed within each sperm class in opposite directions. The segregation frequency of the B sperm class for female offspring increased with father's age (but not mother's age or birth order) and again …
-
Sexually Dimorphic Developmental Patterns of Chemosensory Behaviors in African Elephants (Loxodonta Africana)
… elephants exhibit social dimorphism in which females reside in matriarchal groups while males often travel alone or in bachelor groups. Males search for receptive mates who may advertise their condition through chemical and other signals. The difference in adult lifestyles suggests that the …
-
The effects of diethylstilbestrol on myometrial contractility in mice
… adenocarcinoma, and infertility in both male and female offspring. My study focused on DES-induced structural changes of the myometrium in mice and related them to uterine contractility (strength, duration, and rate) in Balb/c mice treated with 1.0 [micro]g DES or a placebo during a critical …
-
Exploring the sex-specific programming of cardiovascular disease by maternal obesity and assessing potential interventions to the mother
… and the long-term cardiometabolic health of her offspring. Maternal interventions in obese pregnancy are needed to prevent transmission of poor cardiometabolic outcomes between mother and child. Maternal exercise in obese pregnancy in both humans and animal models has shown success for the …
Page 1 of 3