Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 181 for “"female mice"”.
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Loss of basigin expression in the uterus reduces fertility in female mice
… and is important for fertility in both males and females. I hypothesized that loss of Bsg expression in the uterus reduces fertility in female mice by altering implantation, decidualization, lactate transporters and angiogenesis. In mice, global ablation of Bsg is embryonic lethal, which …
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Prenatal exposure to phthalates accelerates reproductive aging in multiple generations of female mice
… detrimental effects on reproduction in males and females. Specifically, in females, phthalates have been shown to accelerate primordial follicle recruitment, disrupt estrous cyclicity, inhibit ovarian steroidogenesis, and disrupt fertility. Furthermore, these effects have been observed in a …
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Behavioral and Neurobiological Consequences of Benzodiazepine Exposure During Adolescence in Male and Female Mice
… I found that ALP exposure during adolescence in mice potentiates the rewarding properties of morphine (MOR) and induces persistent changes in second messenger signaling within the ventral tegmental area -- nucleus accumbens (VTA-NAc) pathway, a neurocircuit implicated in the regulation of drug …
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Genotype effects impact lipids and organ weights in female mice lacking carotenoid cleavage enzymes
… and their metabolites on lipid metabolism in female mice, CMO-I KO, CMO-II KO or wild type (WT) mice, 29-31 weeks old, were fed the following AIN-93G based diets for either 4 or 30 days: lycopene beadlet, 10% tomato powder, and their respective controls. We hypothesized that mice lacking …
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The effect of continuous infusion of human parathyroid hormone on bone architecture in female mice
… infusion of parathyroid hormone (PTH) in adult female mice, and to subsequently study the catabolic effects of PTH. Osmotic pumps were implanted subcutaneously and infused either vehicle, 40 pg/kg/day of PTH or 80 pg/kg/day of PTH for either 2 week or 4 week duration. Total body bone mineral …
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The Effect of Maternal Separation and Postnatal Oxytocin Administration on Social Recognition in Adolescent Female Mice
… dissertation was to determine whether separating female infant mouse pups from their mother, but not siblings, for 3 hrs daily, during the first two weeks of life, influences social recognition during adolescence (Experiment 1). This dissertation also sought to evaluate whether postnatal …
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Examination of voluntary wheel running on markers of adipose thermogenesis in intact and ovariectomized female mice
… wheel running (VWR) in ovariectomized (OVX) mice on whole body energy expenditure and body composition, key protein markers of thermogenesis and adipose tissue browning, and fluctuations in circulating and AT BDNF and receptor content. It was hypothesized VWR would either prevent or mitigate …
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The role of high affinity nicotinic acetylcholine receptors on anxiety-like behavior: a study in female mice
… of β2*nAChRs on anxiety-like behavior in female mice. In this study, antagonism and nicotine effects on anxiety-like behavior was investigated across the life span in 6, 12 and 24-month-old drug-naïve knockout (KO), heterozygous (HET) and a gain of function α6L9S mice and wild type (WT). …
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Nmp4 restricts bone marrow osteoprogenitors and parathyroid hormone induced bone formation in healthy and estrogen depleted female mice
… (PTH) in healthy and ovariectomized (OVX) female mice using a global knockout of the Nmp4 gene. Additionally, these mice have increased bone marrow osteoprogenitors and CD8+ T-cells which support osteoblast differentiation. The animals were not protected from bone loss following OVX, but …
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THE USE OF PREVENTATIVE CANNABIDIOL, CANNABIGEROL, AND MITRAGYNINE TO AMELIORATE MECHANICAL SENSITIVITY OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY IN FEMALE MICE
… but Mitragynine studies showed promise in female-only models. In the present set of experiments, we conduct dose-response studies using both single agents and combinations of these plant alkaloids. These studies were designed to fully evaluate the extent to which these compounds can …
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Antagonizing Dorsal Hippocampal Dopamine D1-type Receptors Affects Social Learning and Social Interactions but not Food Intake in Male and Female Mice
… into the dorsal hippocampus of adult male and female mice. We found that SCH23390 blocked social learning in both male and female mice without influencing total food intake. While there was a sex-specific effect of SCH23390 on certain social behaviors, there was no significant influence of drug …
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Thermoneutral Housing Did Not Impact the Combined Effects of External Loading and Raloxifene on Bone Morphology and Mechanical Properties in Growing Female Mice
… by non-invasive external tibial loading in female mice and combined with raloxifene treatment to assess their combined effect on bone morphology and mechanical properties. Thermoregulation is an important factor that could have physiological consequences on research outcomes, and was …
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Sex-influenced histopathological changes and the immunity during Toxoplasma gondii infection
Studies indicate female mice are more susceptible to T. gondii infection in comparison to male mice. The following studies were undertaken to enhance our understanding about the influence of sex in the immune response during T. gondii infection and the disease outcome in BALB/c mice. Early parasite …
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The sex-dependent interplay of integrin alpha1beta1 and epidermal growth factor receptor in regulating oxidative stress in articular cartilage
… in ex vivo articular chondrocytes of male and female mice. Through confocal microscopy, we determined that chondrocytes of male mice had elevated levels of superoxide compared to female mice. Only male mice demonstrated a condyle effect, with greater superoxide levels in the medial condyles, …
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Characterizing Lung Inflammation in Agricultural Respiratory Exposures Between the Sexes
… including grain dust and pesticides. Although female workers make up approximately 25% of the agricultural working population, the majority of current research on the respiratory and inflammatory effects in agriculture has been conducted on male animal models and workers; very little has been …
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The Influence of Social Experience on Acoustic Communication in Mice
… preference, and perception of USVs in female mice. These experiments were the first comprehensive investigation of whether chronic social deprivation leads to changes in the ways that mice are able to use and understand their USVs. Additionally, I addressed some gaps in knowledge about …
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A Role for Microglia Activation in Modulating Behavior in a Variable Stress Model for Depression
… subregions of the hippocampus in both male and female mice following variable stress. Our findings demonstrate that following 6 days of variable stress female microglia acquire a more activated phenotype compared to microglia in males. These sex specific effects in microglia activation were also …
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Exploring the metabolic role of GPR30 in mice
… for the first time that GPR30 knockout (GPRKO) female mice were protected from high-fat diet (HFD)-induced obesity, glucose intolerance, and insulin resistance. The decreased body weight gain in GPRKO female mice is due to the reduction in body fat mass. These effects occurred in the absence of …
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Men and Women are Not Just From Different Planets: The Role of Sex-Based Differences in the Prevention of Non-Melanoma Skin Cancer
… chronic ultraviolet light B (UVB) exposure, male mice had greater tumor multiplicity, burden, and grade compared to female mice. Additionally, our acute UVB studies revealed decreased antioxidant capacity and cutaneous inflammation in male mice, suggesting that topical antioxidant or …
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