Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"female genital tract"”.
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Impact of the mycobiome on the health of the female genital tract
The female genital tract microbiome comprises a community of microorganisms. Imbalances in the microbiome are associated with vaginal diseases such as bacterial vaginosis (BV) and sexually transmitted infections (STIs). These diseases greatly burden South Africa, and young women in this region are …
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Gene expression patterns of the female genital tract and immunomodulation by Lactobacillus species
Inflammation in the female genital tract (FGT) is associated with increased HIV-1 viral replication, HIV-1 transmission and HIV-1 acquisition. The optimal commensal Lactobacillus bacterial species is associated with reduced inflammation in the FGT and dampened immune responses to non-optimal …
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Effects of hormonal contraceptives on the female genital tract microbiota in South African adolescents
… might affect HIV-1 risk through changes in the female genital tract (FGT) microbiota. We examined the impact of three different HC methods on the adolescent female genital tract microbiota and related cytokine and HIV target cell levels at the cervical mucosa in a randomized, crossover trial. …
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Impact of long-acting contraceptives on female genital tract cytokine profiles in a randomised controlled trial
The Evidence for Contraceptive Options and HIV Outcomes (ECHO) trial found no substantial difference in HIV acquisition risk between women randomised to injectable depot medroxyprogesterone acetate (DMPA-IM), copper intrauterine device (IUD) or the levonorgestrel (LNG) implant. However, it remains …
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Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract
… activation. The role of Th17 cells in regulating genital mucosal immunity during HIV infection is less well described. The aims of this study were (1) to compare the frequency and phenotype of Th17 cells in the female genital tract and blood in uninfected compared to HIV-infected women; and (2) to …
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Role of HAART in reconstituting T-cell function and HIV inhibitory activity in the female genital tract during chronic HIV infection
Includes abstract. Includes bibliographical references.
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Differential effects of combinations of anti-retrovirals and progestins on gene expression and HIV-1 replication in cells of the female genital tract
… of ARVs and hormonal contraceptives in the female genital tract. The mucosal surface in the female genital tract is the initial site of HIV entry and viral replication. Understanding the effect of hormonal contraceptives and ARVs is relevant to the potential safety of these for long term …
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The impact of sexually transmitted infections and inflammation in the female genital tract and blood on susceptibility to HIV-1 infection and disease progression
… that pro-inflammatory cytokine production in the genital tract is necessary for immune cell recruitment and establishment of simian immunodeficiency virus (SIV) infection following vaginal inoculation. The aims of this study were to evaluate the relationships between inflammation in the female …
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HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity
The female genital tract serves as the major portal of entry for human immunodeficiency virus (HIV). Local immune factors unique to the mucosal micro-environment such as the genital tract cytokine milieu or the activation/differentiation status of T cells may play a significant role in heterosexual …
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Co-occurrence of shedding Herpes Simplex Virus type-2 (HSV-2), Human Papilloma Virus (HPV) and Human Immunodeficiency Virus 1 (HIV-1) in the female genital tract among HIV-infected women
… show the presence of other viral STI in the genital region may have increased HIV shedding in the genital region. However, it not clearly known if the presence of ART or HIV may affect the shedding of other viral STI in the genital region and if the combination of other viral STI treatment …
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Comparison of HIV-1 specific T cell immunity in the female genital tract and blood of HIV-infected women : impact of in vitro T cell expansion on HIV-specific T cell specificity, maturational status and functional complexity
… responses detected in the polyclonal expanded female genital tract T cells are associated with those measured in blood during HIV infection.
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The role of seminal plasma in the regulation of inflammation and inflammatory pathways in the cervix: potential for cervical cancer progression and HIV transmission in South African women
… to initiate inflammatory response within the female genital tract. Exposure of neoplastic cervical epithelial cells to SP has been shown to promote the growth of cancer cells in vitro and tumors in vivo by activating several proinflammatory pathways. In addition to the regulation of tumor …
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Effect of HIV infection and pregnancy on parameters of vaginal immunity
The female genital tract is a mucosal epithelium that has an array of factors contributing to the cervicovaginal immune environment. Like with systemic immunity, innate and adaptive immune mediators are integrated in the efficiency for fighting infections in the female genital tract. Our study …
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Regulation of HPV infection and cervical cancer development following a helminth infection
… hookworm infec7on increased pathology in the female genital tract (FGT) following infec7on with the commonly sexually transmi,ed herpes simplex virus (HSV)-2. Although epidemiological studies have linked helminth infec7on with an increased prevalence of the most common sexually transmi,ed …
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Cancer cell behaviour following parasite exposure
… decreased vimentin expression within the female genital tract, confirming the relevance of these in vitro findings. Furthermore, exposure to antigen from the gastrointestinal nematode Heligmosomoides polygyrus decreased the in vitro proliferation of human and mouse colorectal cancer cells …
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The role of HIV-1 subtype B Envelope transmission motifs in subtype C variant infectivity
… (HIV-1) to overcome immune barriers within the female genital tract. One study compared over 5000 subtype B TF and mismatched chronic infection envelope (env) sequences and identified two putative transmission motifs: Histidine at position 12 of the signal peptide (His12) and a potential …
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The role of surfaceant protein A in immunity to HPV16 pseudovirus infection
… agent for the development of various anogenital cancers, including cervical cancer. Worldwide, the majority of cervical cancer cases occur in less developed regions, and while prophylactic vaccines exist to combat HPV infection, they are largely unattainable in these areas. Therefore, …
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Role of the glucocorticoid receptor and HIV-1 Vpr in inflammatory gene expression and HIV-1 LTR transcription in response to dexamethasone and progestogens
… a key point of entry for pathogens in the lower female genital tract (FGT). Quantitative real-time PCR analysis showed that MPA, unlike NET-acetate (NET-A) and P4, increases mRNA expression of the anti-inflammatory GILZ and IκBα genes. Similarly, MPA unlike NET-A, decreases mRNA expression of …
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