Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"feedback regulation"”.
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Feedback regulation in gene networks
… function of their components. Transcriptional regulation is an important part of this multi-level process. By using feedback loops as part of transcriptional gene networks, cells can tune the level and stability of gene expression. In the first half of my thesis, I will discuss how isogenic …
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Feedback Regulation of Human Hematopoietic Stem Cell Fate
… HSC fate. However, fundamentals underlying the feedback regulation of HSC fate are poorly understood. Here, we explored the fundamentals of the feedback regulation of HSC fate at the microenvironmental, intercellular (between cells), and intracellular (inside a cell) levels. First, we developed …
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Feedback Regulation of Wnt Signaling by Naked Cuticle (Nkd) During Drosophila Embryogenesis
… and physiological processes in animals. Deregulation of the Wnt signaling pathway in mammals can cause diseases such as birth defects, cancer, osteoporosis, and diabetes. In Drosophila, the naked cuticle (nkd) gene antagonizes the Wnt/beta -catenin signaling in every segment of the embryo. …
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Feedback regulation of nitrogenase and response of a hypernodulating soybean mutant to increased photosynthate supply
… results are consistent with the idea that the feedback control of nodulation and nodule activity is located in the shoot and indicated that asparagine may be the signal molecule involved in sensing of soybean N status. These results also indicated that partial-NO$\sb3\sp-$ tolerance of …
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Negative feedback regulation as a means to constrain the oncogenic potential of mutant Egfr in NSCLC
… germline mutant mice revealed significant downregulation of the mutant receptor, and this was predominantly at the post-transcriptional level. These data suggest that normal cells can respond to an oncogenic lesion by upregulating negative feedback pathways to counteract the induction of …
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Direct Regulation of Apoptosis By Linear Ubiqutin Chain Assembly Complex (Lubac) and Feedback Regulation of Lubac Function By Caspases
… pathway, the precise mechanism of apoptosis regulation remains unknown. Moreover, NF-κB and apoptosis pathways have opposed but fundamental functions for various cellular processes. Although these two pathways actively interplay to balance the death and survival, the reciprocal regulation …
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A four-cysteine zinc finger in carboxyltransferase structurally links the functions of enzymatic activity and negative feedback regulation of translation
… mechanism of carboxyltransferase translational regulation not captured by the current model.
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Regulation of morphogen signalling during neural patterning in the Xenopus embryo
… FGF4 and FGF8 gene activities, allowing positive feedback regulation. We also show that xHtrA1 triggers proteolytic cleavage of xBiglycan, xSyndecan-4, and xGlypican-4, suggesting a model, in which xHtrA1 through cleaving proteoglycans releases FGF/proteoglycan complexes that act as long-range …
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Molecular Mechanism of Aurora-A Kinase in Human Oncogenesis
… study, we have demonstrated: 1) transcriptional regulation of Aurora-A by E2F3; 2) feedback regulation between tumor suppressor CHFR and Aurora-A; 3) CNTD2 as a novel Aurora-A partner and oncogene to activate Aurora-A and induce transformation. Aurora-A expression and activity are cell cycle …
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Identification and analysis of Arabidopsis thiamine pyrophosphate transporters
… have been characterised, and a mechanism of feedback regulation for thiamine biosynthesis via riboswitching has been unravelled. In plants, thiamine is made in the chloroplasts and then transferred to the cytosol to generate the active form of thiamine, TPP. The mitochondria and chloroplasts …
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The hemo-neural hypothesis : effects of vasodilation on astrocytes in mammalian neocortex
… often and as strongly as the reverse, suggesting feedback regulation between vascular diameter and astrocytic calcium activation levels.
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SR proteins in microRNA/mRNA biogenesis
… are a family of splicing factors involved in the regulation of both constitutive and alternative splicing of pre-mRNAs. Despite years of studies, several big questions still remain: how the expression levels of SR proteins are regulated; what are the underlying mechanisms responsible for SR …
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Stress response and habituation as influenced by nutritional and thermal factors in dwarf and normal chickens
… the fast. corticosterone mediated inhibitory feedback regulation of the hypothalamic - pituitary - adrenal axis which down-regulates ACTH response was also evident.
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Bile Acids and Nuclear Receptors: Their Roles in Nutrition and Cancer
… as farnesoid X receptor (FXR), is essential for feedback regulation of bile acid synthesis. Bile acids are required for the proper absorption of dietary lipids, including fat-soluble vitamins; however, some bacterial metabolites of bile acids have been shown to promote intestinal tumorigenesis in …
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Studies on the mode of CRF action in the optic tectum of the African Clawed Frog, Xenopus laevis
… neuroanatomical evidence for the direct GABA regulation on CRF signaling pathway. The fourth chapter used the fluorescent Ca2+ marker to show the real-time Ca2+ concentration in response to CRF, but failed to prove the Ca2+ flux was able to be regulated by CRF or GABA. The last chapter used …
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Understanding the molecular mechanism of postharvest seed coat darkening in pinto beans
… and thus ensuring substrate flow to maintain a feedback regulation for upstream epicatechin biosynthesis. Knowing the mechanism and committed steps of the PA pathway will not only help tackle postharvest darkening issues but also will make it easy to incorporate other beneficial traits in SD …
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The Measure of Emotion During an Attention Demanding Task and Mindfulness Biofeedback for Improved Selective Attention
… 2018, Farb et al. 2015; Kabat‐Zinn, 2003). Biofeedback training is a method of self-regulation of autonomic responses (Moss, 2016). Mindfulness biofeedback (MB) has recently gained attention regarding its benefits (Khazan Moss, 2020). MB improves athletic performance (Perry, 2018); however, the …
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Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… and outflow tract anomalies along with downregulation of particular neural crest-derived pharyngeal arch mesenchyme markers. Mice deficient for both Gaq and Ga 11 are phenotypically similar to EtA or Et-1-null mice. My analysis of expression patterns of Et-1 dependent and independent …
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Investigation of regulatory and functional diversity in an enzyme superfamily
… revealed the conservation of the mechanism of regulation in these different versions of IPMS enzymes. The presence of identical feedback regulation mechanisms in distinct enzymes indicates the complexity of identifying structure/function relationships in multidomain allosteric enzymes. To …
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