Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"feedback inhibition"”.
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The identification of the mTOR-regulated phosphoproteome and a mediator of feedback inhibition to P13K-Akt
… as an mTORC1 substrate that mediates the inhibition of P13K typical of cells lacking TSC2, a tumor suppressor and negative regulator of mTORC1. Phosphorylation of Grbl 0 is important for its inhibitory function as well as for its stability. While acute mTORC1 inhibition results in changes …
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Activity-Dependent Regulation of Inhibition from Different Inhibitory Subtypes
… maintenance of neocortical circuitry. A negative feedback mechanism by which neuronal circuits adapt to changing levels of average activity on a time scale of hours to days is known as homeostatic plasticity. At the simplest level, homeostatic adaptations occur to maintain firing rate of neurons …
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Vβ Recombination Signal Sequences Mediate Monoallelic And Monogenic Tcrβ Gene Assembly: Implications For The Tcrβ Repertoire And Allelic Exclusion In Health And Disease
… of an in-frame gene on one allele, transient inhibition of V(D)J recombination signaled by RAG DNA double stranded breaks (DSBs), and the resulting protein sending feedback signals to permanently inhibit V-to-(D)J recombination of the non-functional allele. Any definitive mechanisms that …
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Charakterisierung von NadR : das essentielle Enzym der NAD-Synthese bei Haemophilus influenzae
… in vitro Experimenten konnte für NadR eine Feedback-Inhibition durch das NAD+ gezeigt werden, wobei NAD+ in erster Linie die RNK Domäne von NadR inhibiert. Eine graduelle Erhöhung der NAD+ Konzentration führte in den in vitro Assays zu einer graduellen Abnahme der RNK. Bei der NMNAT …
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The use of mineral oil as a trapping agent for volatiles produced by Ceratocystis moniliformis (Hedg.)
… is limited due to toxicity, or perhaps a feedback inhibition mechanism. Seventeen volatile aroma compounds were tentatively identified by Gas Chromatography - Mass Spectrometry (GC- MS), and of these, the production of isoamyl acetate, B -myrcene, acetophenone, i1-octanol, and geraniol was …
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The Role of Insig-Mediated Cholesterol Homeostasis in Mouse Hair Development
… very homologous proteins, are indispensable for feedback inhibition of cholesterol biosynthesis. Mice null for both Insigs drastically overproduce cholesterol and its precursor sterol intermediates and exhibit many developmental abnormalities such as cleft palate. In this work, we generate and …
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The role of fast-spiking interneurons in cortical map plasticity
… this is mediated by a period of persistent disinhibition in deprived cortex that enables the expansion of spared whisker representations. Alternatively, it has been proposed that inhibition undergoes a biphasic change with an initial, brief period of disinhibition to promote plasticity in …
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The Role of Periplasmic Disulfide Bond Status in the Regulation of the Salmonella SPI1 Type Three Secretion System
… regulation and SPI1 function. The dsbA-mediated feedback inhibition on SPI1 transcription is not due to defects in the SPI1 T3SS apparatus. Rather, the transcriptional response is dependent on both the flagellar protein FliZ and the RcsCDB system, which also affects fliZ transcription. Thus, the …
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A quantitative study of the relationships between morphology, physiology and geldanamycin synthesis in submerged cultures of Streptomyces hygroscopicus var. geldanus
… but regulate geldanamycin synthesis through feedback inhibition of the direct metabolic pathway. This study has demonstrated that, in Streptomyces hygroscopicus var. geldanus, the bulk of factors that affect morphology impact significantly on respiration, and it is this parameter that is the …
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Purification and characterisation of novel recombinant β-glucosidases from aspergillus with application in biofuel production
… cellobiose to glucose, but also remove the feedback inhibition effects of cellobiose on exoglucanase and endoglucanase thereby increasing the rate of cellulose degradation to fermentable sugars. A total of 166 proteins were identified as β-glucosidases after manual BLASTp search on the …
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Investigating the Pyrr-Pyr mRNA Interaction Through Site-Directed Mutagenesis of the PyrR Protein
… operon in Bacillus subtilis is regulated by a feedback inhibition loop involving the product of the first gene of the operon, PyrR, and the downstream products of the pathway, uridine nucleotides. Regulation occurs through a transcriptional attenuation mechanism in which PyrR binds in the …
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Production of biofuels and biodegradable plastics from common waste substrates in engineered Ralstonia eutropha
… of both the pathway enzyme for reduced-feedback inhibition, in addition to genotypic adaptation to exogenous isobutanol stress produced insights that will allow for further improvements on isobutanol production. Furthermore, strains of R. eutropha were also engineered to produce …
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FITSelect: An Invention to Select Microbial Strains Maximizing Product Formation from a Single Culture Without High-Throughput Screening
… screening. This novel system is called Feed-back Inhibition of Transcription for Growth Selection (FITSelect), and it uses a natural feedback inhibition mechanism in the L-arginine production pathway to select strains (transformed with a random genomic library) that can over-produce L-arginine in …
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Characterization of the regulatory domain of the mammalian multifunctional De Novo pyrimidne biosynthetic enzyme CAD
… in the mammalian de novo pathway. It undergoes feedback inhibition by UTP and activation by PRPP, a purine precursor that coordinates purine and pyrimidine biosynthesis, and by cAMP-dependent protein kinase phosphorylation. Several lines of evidence have demonstrated that the carboxyl end (B3) …
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Towards a Better Treatment of Parkinson's disease
… blocking the dopamine autoreceptor-mediated feedback inhibition of dopamine neurons, potentiate L-DOPA's effect on individual basal ganglia neurons and its antiparkinsonian effects in Parkinsonian animals. Electrophysiology (extracellular single-cell recording in the globus pallidus) and …
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Molecular and Physiological Analysis of Putative Amino Acid Transporters in Arabidopsis Thaliana
… was valine uptake mutant rather than a loss of feedback inhibition mutant of acetohydroxy acid synthase. Segregation analysis suggested, however, that the T-DNA insertion was not linked to the valine resistance phenotype. The analysis also revealed a poor penetrance of the valine resistance …
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The Overexpression of a Feedback -Insensitive Anthranilate Synthase in Arabidopsis and Tobacco
… Trp biosynthetic pathway. The activity of AS is feedback inhibited by Trp and its analogs such as 5-methyl Trp (5-MT). Trp analogs are toxic to cells because they cause false feedback inhibition of AS and hinder the normal production of Trp. A feedback insensitive AS gene (ASA2) was previously …
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The direct effects of estradiol and several xenoestrogens on cell numbers of early- vs. late-stage prostate cancer cells
… decrease androgen production by central negative feedback inhibition, but may also have direct tumor killing mechanisms by a less well understood mechanism. To elucidate these mechanisms and provide understanding for potential future therapies, we identified cellular pathways and rapid signaling …
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The conservation of suppressor of Cytokine Signalling 3 in mediating intestinal homeostasis
… pathway and this is an inducer of negative feedback inhibition and is implicated in regulation of intestinal homeostasis, with SOCS3 dysregulation reported in intestinal pathologies, such as cancer and inflammatory bowel disease. Intestinal epithelial cells are also in close proximity to the …
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Molecular-genetic characterisation of arginine auxotrophy in the opportunistic human pathogen, Pseudomonas aeruginosa
… regulatory domain was anticipated to disrupt feedback inhibition of the enzyme. Counter-intuitively, the Tn insertion may therefore elevate the level(s) of certain intermediates in this arginine biosynthetic pathway. The proteomic analysis also provided insight into the likely cellular …
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