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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"fed-batch"”.
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Optimal control of fed-batch fermentation processes
Optimisation of a fed-batch fermentation process typically uses the calculus of variations or Pontryagin's maximum principle to determine an optimal feed rate profile. This often results in a singular control problem and an open loop control structure. The singular feed rate is the optimal feed …
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Perturbation-based Control of Industrial Fed-batch Bioprocesses
… control of industrial-scale microbial fed-batch bioprocesses. Its focus is therefore on methods which are easy to implement in an industrial setting, which gives certain limitations on sensors, actuators and control systems. The main part of the work in the thesis concerns control of …
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Modelling of batch and fed-batch ethanol fermentation
Two series of batch and fed-batch fermentations were carried out using S.cerevisiae in a semi-defined medium containing 200 gl-1 glucose as limiting substrate. Growth rates were calculated and the data used to test the applicability of eight empirical kinetic models. The form proposed by …
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Dynamic operation of mammalian cell fed-batch bioreactors
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Applied Biological Sciences, 1992.
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The application of fuzzy control to fed-batch fermentation
Fermentation processes are highly nonlinear and subject to variability. The fermentation's states are not readily available on-line and therefore the application of closed loop control schemes have been hindered. It was decided to investigate fuzzy control as it is able to deal with systems whose …
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Hybride Modellbildung zur Prozessführung von Fed-Batch-Kultivierungen mit Aspergillus niger
… the growth and product formation of A.niger in fed-batch cultivations is modelled by using the enzyme glucoamylase as an example product. Since classical modeling of bioprocesses involves a great deal of effort, a hybrid modeling approach is being pursued that combines biologically motivated …
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Probing Control : Analysis and Design with Application to Fed-Batch Bioreactors
… the technique to the control of feed supply in fed-batch fermentations of the bacterium Escherichia coli. The thesis is divided into three parts. In the first part, the convergence properties of the probing algorithm are examined. The analysis is limited to processes modeled by a linear …
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Studies on the fed-batch propagation of brewer's yeast in high gravity wort
The traditional batch brewing process is characterised by serial yeast propagation to build sufficient yeast for pitching. This results in cyclic variations in yeast environment, leading to a slow brewing process. In high gravity brewing the carbohydrate utilisation is inefficient as a result of …
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Stoichiometric medium design and nutritional control in fed-batch cultivation of animal cells
Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1997.
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Modeling based process development of fed-batch bioprocesses: L-valine production by Corynebacterium glutamicum
A framework for modeling and optimization was written in the Matlab environment. The system allows the use and simulation of dynamic multivariable experiments. Models can be fitted to the experimental data and the accuracy of the parameter estimates can be regarded. Also the accuracy of the model …
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Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch
… of antibody producing CHO cell cultures in fed-batch bioreactors. Multivariate monitoring techniques in biopharmaceuticals has resulted in the generation of large amounts of data comprising real-time measurements of critical quality and performance attributes, and if exploited efficiently …
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Design of an optimised fed-batch process for insulin precursor production in Pichia pastoris
… developed in this study employed a two-stage fed-batch feeding strategy in which growth was optimised by feeding glycerol to boost biomass followed by induction of the gene encoding insulin precursor by feeding methanol.
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Metabolic activity control of the L-lysine fermentation by restrained growth fed-batch strategies
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1992.
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Development of mathematical descriptions of mammalian cell culture kinetics for the optimization of fed-batch bioreactors
Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Applied Biological Sciences, 1987.
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Entwicklung und Anwendung einer Fed-batch-Betriebsweise mit Nährstofffreisetzungssystemen zur kontrollierten Kultivierung und zum Screening von Mikroorganismen in Schüttelreaktoren
… industrial production processes are performed in fed-batch operational mode. In contrast, the screenings for microbial production strains are run in batch mode which results in completely different physiological conditions than relevant for production. This may lead to wrong strain selections. …
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Process Intensification of Spodoptera frugiperda (Sf) Cell Growth via Multi-Parallel Bioreactor System
… of this project is to improve the yield of the fed-batch manufacturing process for the production of Flublok influenza vaccine, which was approved by the FDA in 2018. In short, Spodoptera frugiperda (SF+) insect cells are grown to a specific target cell density and then infected with baculovirus …
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MOLECULAR ROLES OF HSP27 IN IMPROVING MONOCLONAL ANTIBODY PRODUCTION OF CHO CELLS
… AND STATIONARY GROWTH PHASE OF CHO FED-BATCH BIOREACTOR CULTURES, MAKING IT A POTENTIAL CELL LINE ENGINEERING TARGET FOR IMPROVING RECOMBINANT BIOLOGICS TITRES IN CHO CELLS. IN THIS THESIS, CHO CELLS WERE ENGINEERED TO OVEREXPRESS HSP27 AND ITS EFFECTS ON CELL GROWTH, MAB PRODUCTION …
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Control strategies for exothermic batch and fed-batch processes A sub-optimal strategy is developed which combines fast response with a chosen control signal safety margin. Design procedures are described and results compared with conventional control.
… It can be applied to both exothermic batch and fed-batch processes. It consists of servo and regulatory modes, where a Generalized Predictive Controller (GPC) was used to provide self-tuning facilities. The methods outlined allow for limited thermal runaway whilst keeping some spare …
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Experimental investigations of isotopologue fractionation during microbial methanogenesis
… during microbial methanogenesis. Chapter 2 uses batch and fed-batch culturing systems to investigate the effects of H₂ concentrations on isotopologue fractionation. The results from fed-batch experiments confirmed the previous observation of decoupled ¹³C/¹²C and D/H systematics and provide …
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