Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 114 for “"fatty liver disease"”.
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Personalised Medicine for Non-Alcoholic Fatty Liver Disease
Non-Alcoholic Fatty Liver Disease (NAFLD) is a chronic and dangerous condition which has grown in prevalence over recent decades due to increasing rates of obesity, affecting roughly a quarter of adults globally. This thesis develops a useable NAFLD definition which can be applied to large …
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The role of MBOAT7 on fatty liver disease
https://gupea.ub.gu.se/handle/2077/67133
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Non-invasive diagnosis of non-alcoholic fatty liver disease.
Non-alcoholic fatty liver disease (NAFLD) has become one of the top concerns for the practising hepato-gastroenterologist due to the obesity epidemic and its potential to progress to an advanced liver disease that significantly impacts on overall and liver-related mortality. Due to the rapidly …
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Engineering in vitro models of non-alcoholic fatty liver disease
… the world. Consequentially, non-alcoholic fatty liver disease (NAFLD), which is highly correlated with obesity, rates are also increasing with greater than 30% of the US population currently diagnosed. NAFLD starts as a benign state of fat accumulation within liver hepatocytes but often …
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Hepatoprotective properties of Gentiana SPP: Against non-alcoholic fatty liver disease (NAFLD)
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterised by the accumulation of fat in the liver. It is estimated that 33 % of the UK population have NAFLD with 2-5 % progressing to non-alcoholic steatohepatitis (NASH). Due to a lack of an outright therapy for NAFLD, treatment …
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Aerobic exercise training as a mitigator of nonalcoholic fatty liver disease related fibrosis
… Nonalcoholic steatohepatitis (NASH) is a liver disease that is associated with obesity and is characterized by inflammation and fibrosis (scar tissue) within the liver. This condition is difficult to study in humans, therefore rodent models often are used to better understand factors that …
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Effect of the ligands of thyroid hormone receptor on non-alcoholic fatty liver disease
The term non-alcoholic fatty liver disease (NAFLD) has been used as a general name for conditions ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. End-stage NAFLD cirrhosis carries a substantial risk for early hepatocellular carcinoma development. Therefore, there …
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PKC-δ and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: Effect of Vitamin D
ABSTRACT|Nonalcoholic fatty liver disease (NAFLD) due to excess ectopic fat deposit in the liver of nonalcoholic is a broad spectrum of liver diseases encompassing simple liver steatosis to more complicated and morbid steatohepatitis (NASH) that can lead to cirrhosis and even to hepatocellular …
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Mechanisms into the development of fatty liver disease: role of free fatty acids and alcohol
Background: Alcohol and Free fatty acids such as palmitate are known to promote liver injury. However less mechanistic information is available regarding omega fatty acids ratios with/out alcohol. In healthy populations omega 6/3 ratios are between 1:1 to 4:1, whereas high ratios (>15:1) are …
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Mechanisms into the development of fatty liver disease: role of bile acids, Betaine and MHY908
Background: Non-alcoholic fatty liver disease (NAFLD) is an emerging epidemic worldwide. It is a metabolic condition that etiologically parallels with obesity, type 2 diabetes, and the metabolic syndrome. However, the pathogenesis of NAFLD remains elusive, though it is known free fatty acids such …
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Effects of vitamin D on pro-inflammatory cytokines associated with Non-alcoholic fatty liver disease
ABSTRACT|Non- alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in the United States, affecting approximately one-third of the population. The prevalence of NAFLD increases to 90% in morbidly obese individuals. Many studies have shown a negative association between …
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A systems biology approach to the pathogenesis and progression of Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) refers to a spectrum of diseases ranging from simple steatosis (isolated hepatic fat accumulation) to steatohepatitis (NASH; hepatic fat accumulation with lipotoxicity, hepatic cell damage and inflammation), eventually progressing to fibrosis, cirrhosis and …
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Investigation of Microbiome Metabolites and Mitochondrial Function in a model of Non-Alcoholic Fatty Liver Disease
… produced by gut bacteria have been linked to disease including non-alcoholic fatty liver disease (NAFLD). Trimethylamine N-oxide (TMAO) and phenylacetic acid (PAA) are microbiome-derived metabolites that have been associated with early onset of NAFLD. Hypothesising that these metabolites …
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INVESTIGATING THE ROLE OF LIPID DROPLETS AS INTRACELLULAR MECHANICAL STRESSORS IN NON-ALCOHOLIC FATTY LIVER DISEASE
… external mechanical stress have been linked to disease and cancer development in multiple tissues, including the liver, where cirrhosis (which increases stiffness markedly) is the major risk factor for hepatocellular carcinoma (HCC). Stiffness is correlated with cancer development and patient …
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Non-Alcoholic Fatty Liver Disease: Investigating the Impact of Bariatric Care and the Role of Immune Function
Non-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis (SS) to nonalcoholic steatohepatitis (NASH) and cirrhosis. It is one of the most common causes of chronic liver disease resulting from obesity. 74-98% of morbidly obese individuals have NAFLD at the time of bariatric surgery. …
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Biopsychosocial profile of non-alcoholic fatty liver disease (NAFLD) associated with liver transplantation and prevention of risk factors
En la presente Tesis Doctoral se han llevado a cabo un estudio teórico y cinco trabajos empíricos y pioneros que abordan principalmente distintos perfiles biopsicosociales de pacientes con EHGNA asociados, por un lado, a los distintos niveles de gravedad de la enfermedad hepática y, por otro lado, …
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