Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 82 for “"fatty acid oxidation"”.
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Chickens Selected for High Body Weight Show Relative Impairment in Fatty Acid Oxidation Efficiency and Metabolic Flexibility in Skeletal Muscle and White Adipose Tissue
… HWS chickens are associated with altered fatty acid oxidation efficiency and metabolic flexibility in tissues associated with energy sensing and storage, and relative cellular hypertrophy in white adipose tissue. Hypothalamus, liver, Pectoralis major, gastrocnemius, abdominal fat, …
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The Role of Neuropeptide Y Y1R in Skeletal Muscle Lipid Metabolism
… myotubes were incubated in 14C palmitate labeled fatty acid oxidation medium containing 80ng/mL, 250ng/mL, and 500ng/mL of NPY and for a three hour period. Experiments were repeated with the addition of 17mg/mL diprotin A to each NPY treatment. Fatty acid oxidation (FAO) and the percentage of …
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Advancing Dynamic Imaging for Microfluidic Stimulated Tissues: Biology, Techniques, and Applications
… transfer flavoprotein (ETF) autofluorescence to fatty acid oxidation in living pancreatic islets. We found that elevated glucose (>10 mM) decreases the ETF redox state within 20 minutes in islets when presented with a mixed nutrient condition associated with glucolipotoxicity. This observation …
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The Role of Angiotensin II in Skeletal Muscle Metabolism
… hours and a number of effects were investigated. Fatty acid oxidation and lipid synthesis was measured using [1-14C]-palmitate, glucose oxidation and glycogen synthesis were measured using 14C-glucose. In addition,mitochondrial oxidative capacity was measured using an XF 24 Flux Analyzer (Seahorse …
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Regulation of Highly Unsaturated Fatty Acid Metabolism
… are considered as the main regulators of fatty acid oxidation and synthesis, respectively, including metabolism of highly unsaturated fatty acids (HUFAs). The objective of the first project was to investigate functional differences of PPARalpha between species. PPARalpha is essential for …
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L-Carnitine Supplementation for Periparturient Dairy Cows
L-Carnitine is required for mitochondrial oxidation of long-chain fatty acids. The objectives of this research were to determine whether L-carnitine supplementation increases hepatic fatty acid oxidation and decreases liver lipid accumulation in dairy cows. In experiment 1, 8 mid-lactation cows …
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The Role of High Saturated Fatty Acid Diets on Skeletal Muscle Metabolism and Inflammation
… Skeletal muscle samples were used to measure fatty acid oxidation, glucose oxidation, oxidative enzyme activities, mRNA expression of metabolic targets, and phosphorylation and total content of inflammatory proteins. In response to five days of high SFA feeding, skeletal muscle glucose and …
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Development of gas chromatography/mass spectrometry analysis of urinary acylcarnitines : application to metabolism studies
The metabolism of fatty acids in humans is recognized as an important source of energy. It is especially vital to newborn infants when metabolic pathways are often stressed as the early stages of life demand fundamental changes and developments of body processes. Defective fatty acid oxidation …
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Investigating IL-15 Metabolic Impact and Its Mechanism of Action in Skeletal Muscle Cells
… glucose uptake in muscle and whole-body fatty acid oxidation and its overexpression in skeletal muscle in mice generates a very lean and active phenotype. However, there are discordant reports throughout scientific literature. The aim of the current study was to 1) characterize the …
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Transcriptional Regulation of Melanocortin 4 Receptor by Nescient Helix-Loop-Helix-2 and its Implications in Peripheral Energy Homeostasis
… energy expenditure, glucose homeostasis and fatty acid oxidation are reported. To investigate the transcriptional mechanisms of Mc4r and the involvement of Nhlh2, gene expression analysis, DNA-protein binding, transactivation assays, and SiRNA induction were used. We show that Nhlh2 regulates …
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Amylin, tissue hypoxia and metabolic dysregulation in diabetic heart and liver
… islet amyloid polypeptide (IAPP), is a 37 amino-acid peptide hormone, that is co-secreted with insulin from pancreatic β-cells in response to nutrient stimuli. Amylin dyshomeostasis occurs in T2DM. Initially, as peripheral insulin resistance develops, β-cells compensate by increasing insulin …
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INTERDEPENDENT REGULATION OF METABOLISM AND INFLAMMATION IN HUMAN MONOCYTES
… late sepsis is marked by immune suppression and fatty acid oxidation. As an increasing body of data suggests, these metabolic and immune states may be interdependent.
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Metabolic lipid regulation during developmental stress : fatty acid dynamics in fasting northern elephant seals.
Long chain fatty acids (LCFA) are important as fuel during exercise in humans, yet have pathological consequences during LCFA overabundance. The northern elephant seal (NES) (Mirounga angustirostris) is a temporally insulin resistant, deep-diving marine mammal reliant on fatty acid oxidation during …
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Effects of carnitine on medium-chain fatty acid metabolism in newborn pigs
Metabolism of medium-chain fatty acids (MCFA) is considered to be independent of carnitine because of their passive diffusion into the mitochondrion. However, upon feeding medium-chain triglycerides (MCT) to piglets (n = 16) followed by serial blood sampling, we observed significant changes in free …
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CARDIAC ENERGY METABOLISM IN ISCHAEMIA AND TYPE 1 DIABETES
… diabetic heart becomes more dependent upon the oxidation of fatty acids (FAO) for ATP synthesis due to an inability to regulate blood glucose concentration. The work presented in this thesis aimed to further our understanding of substrate selection and metabolism in the ischaemic and type-1 …
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Skeletal Muscle Adaption to 5 days of High-Fat Feeding in Humans
… impaired insulin signaling, as well as decreased fatty acid and glucose oxidation. Utilizing proteomic analysis of metabolic proteins in humans may lead to the mechanism behind skeletal muscle adaption to macronutrient composition, potentially providing the groundwork for characterizing the …
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Farnesol-Mediated Regulation Of Hepatic Lipid Metabolism In Heparg Cells
<p>Non-alcoholic fatty liver disease is emerging as one of the most common liver disorders worldwide and is characterized by accumulation of triglycerides (TGs) in liver. The endogenous isoprenoid farnesol reduces hepatic TG levels in rodents, and this effect appears to involve at least two nuclear …
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The role of Toll-like Receptor 4 in the Modulation in Skeletal Muscle Metabolism
… in skeletal muscle results in the preferential oxidation of glucose for ATP production over that of fatty acids. Currently, the exact mechanism(s) for TLR4-induced modulation of metabolism are not known. The purpose of this project was to test the hypothesis that activation of TLR4 pathway …
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The role of AMP-activated protein kinase in endothelial VEGF signalling
… activation has been demonstrated to stimulate fatty acid oxidation in endothelial cells. However, exposure of HAEC to VEGF did not alter fatty acid oxidation in the present study. Together, the current investigation suggests that a VEGF-Ca2+-CaMKK-AMPK-eNOS- NO pathway is present in HAEC, and …
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Hepatic gene networks due to the trans-10, cis-12-conjugated linoleic acid supplementation in growing male mice
Trans-10, cis-12-conjugated linoleic acid (trans-10, cis-12-CLA) has been reported to reduce body fat mass but accompanied by increased liver mass. However, the cellular and molecular mechanisms have been unknown. Our study investigated the effects of trans-10, cis-12-CLA supplementation on hepatic …
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