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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"fatty acid binding protein"”.
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Neuroprotective Functions of Docosahexaenoic Acid and Epidermal Fatty Acid Binding Protein
… Using NGFDPC12 cells we show that palmitic acid (PA) induces the expression of stress response genes HIF-1α and BNIP3, increases the accumulation of reactive oxygen species, and decreases cell viability by apoptosis. Inhibition of cathepsins does not rescue neurons from PA-LTx but inhibition …
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Expression and Requirement of Epithelial Fatty Acid- Binding Protein in Neuronal Axon Growth
<p>Epithelial fatty acid-binding protein (E-FABP) is expressed in the dorsal root ganglia following sciatic nerve injury and in migrating and differentiating neurons during neuronal development. It was hypothesized that E-FABP expression is required for the robust outgrowth of axons from developing …
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Examination of Brain-Fatty Acid Binding Protein Interaction with Hydrophobic Ligands and Micelles
Members of the fatty acid binding protein (FABP) family function as intracellular transporters of hydrophobic molecules, facilitating both fatty acid and lipid metabolism. FABPs share a common tertiary structure of beta barrel pocket for ligand incorporation with a flexible lid domain. Dysfunction …
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Isolation and Characterization of Fatty Acid Binding Protein From Lactating Bovine Mammary Gland
An intracellular protein which binds fatty acids had been found in a wide range of organisms and tissues. Its presence had not been documented in mammary tissue. The purpose of this study was to determine whether fatty acid binding protein (FABP) exists in bovine mammary tissue and if so, to …
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Effects of low and high intensity exercises on serum mean values of myoglobin and heart-type fatty acid-binding protein in athletes
… fast-twitch (ST and FT) fibers, respectively. Fatty acid-binding protein (FABP) is one of the novel and promising plasma markers for detection of tissue injury. Heart-type (H)-FABP appears to be a valid serum biomarker for the early diagnosis of: AMI, stroke, and acute muscle damage. The ratio …
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Design and synthesis of novel compounds as fatty acids binding protein inhibitors and as gallium-68 chelators for positron emission tomography
… discussed. In the first one, the design of new Fatty acid binding protein 4 inhibitors is discussed. In the second one, the design of two targeting peptide bioconjugates for the detection of cancers is reported. Fatty acid binding proteins are a class of proteins involved particularly in the …
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Caratterizzazione proteomica di fluidi e tessuti in diverse condizioni fisio-patologiche
… study has been performed in order to compare the acid-insoluble fraction of saliva from preterm with at-term newborns and adults and establish if differences exist. In the second study medulloblastoma and pilocytic astrocytoma pediatric brain tumor extracts have been compared. In both studies 2- …
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Exploring Protein-Ligand Interaction with Rotamer-Library Based Refinement Tools
… extensively used for the predicting and refining protein sidechains, loops and tertiary structures. These refinement techniques have been expanded to allow the inclusion of protein-ligand interactions by developing and evaluating methods for creating rotamer libraries for small drug-like …
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Role of IGF-II, PRL, and FABPs in the Breast Cancer Disparity among AA Women
… stimulates the expression of intracellular fatty-acid binding protein 3 (FABP3). FABP3 is detected in human breast tissue and is known as mammary-derived growth inhibitor (MDGI) because it has a strong inhibitory effect on cell proliferation. FABP5 is also expressed in the breast, and has …
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Uncoupling Lipid Metabolism from Inflammation in Adipose Tissue
… with obesity, such as type 2 diabetes, fatty liver disease, cardiovascular disease, and hyperlipidemia cost billions of dollars to health care annually. One such major obesity-linked syndrome is the development of insulin resistance, which can lead to other systemic complications. …
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Identification of Anti-inflammatory and Antioxidant Properties of MangostinXanthones in Adipocyte Reporter Assays
… factor κB response element (<i>Nfkb</i>-RE)/GFP, fatty acid binding protein 4 promoter (<i>Fabp4</i>-P)/CFP, and nuclear factor erythroid 2-related factor2 promoter (<i>Nrf2</i>-P)/YFP fluorescent reporters. We hypothesized that fluorescent signals directly correlated to inflammatory, adipogenic, …
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Cellular mechanisms of environmental enrichment: Novel discovery-based strategies for target identification for neuropsychiatric disorders
… transcriptomic/proteomic analysis of mRNA and protein regulated by enrichment and cocaine. This strategy identifies AKT signaling as a promising pathway; therefore, we knocked down the downstream target of AKT, glycogen synthase kinase 3 (GSK3) beta, with a novel adeno-associated viral (AAV) …
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Apolipoprotein M – Studies of Structure and Function
Apolipoprotein M (apoM), a 25 kDa plasma protein, is found in all major lipoprotein classes, although the majority is found in high density lipoproteins (HDL). ApoM has been suggested to be involved in the formation of and adding to the antiatherogenic functions of HDL, but its function is still …
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Cyst morphology and serological variation in cystic echinococcosis patients from Turkana, Kenya
… beta/delta (EgEF-1β/δ), Echinococcus granulosus fatty acid binding protein 1 (EgFABP1), Echinococcus granulosus heat shock protein 70 (EgHSP70) and Echinococcus granulosus thioredoxin peroxidase (EgTPx). Crude hydatid cysts fluid was also used for comparison. The optimised antigens were then …
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Characterisation of a panel of recombinant antigens from Echinococcus granulosus and their role in the immunological follow up, after treatment, of cystic hydatid patients from Turkana, Kenya
… were selected andused to synthesise recombinant fatty acid binding protein 1 (EgFABPI), heatshock protein 70 (EgHSP70), thioredoxin peroxidase (EgfTPx) elongation factor1-beta/delta (EgEF1-(3/6) and antigen B (EgAgB) fusion proteins respectivelycarrying N-terminal His-tagged sequences. A panel of …
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The Role of Autotaxin in Cancer
… (LPC) into lysophosphatidic acid (LPA). LPA is the agonist for at least six G protein coupled receptors whose activation stimulates cell proliferation, survival and migration. Overexpression of ATX and increased levels of LPA have been linked to fibrotic and inflammatory …
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Copper from copper hydroxychloride in diets for growing pigs increases feed efficiency, improves energy utilization and changes intestinal microbial activity
… digestibility of nutrients, intestinal microbial protein, immune response, intestinal permeability, and lipid metabolism of pigs. The first 3 experiments were conducted to determine effects of Cu hydroxychloride on digestible energy (DE) and metabolizable energy (ME), apparent total tract …
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Neue Biomarker und Multimarkerstrategien für eine optimierte Risikostratifizierung von Patienten mit Lungenembolie
… der neuen kardialen Biomarker heart-type fatty acid-binding protein (H-FABP) und growth-differentiation factor-15 (GDF-15) für die Risikostratifizierung von Patienten mit akuter Lungenembolie untersucht. In einem Patientenkollektiv von 107 Patienten erwies sich H-FABP als zuverlässiger …
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Investigating the role of toll-like receptor 4 in myocardial ischaemic-preconditioning and ischaemic-reperfusion injury
… recovery after ischaemic insult. Although protein analyses revealed that cardiac fatty acid binding protein (cFABP) and high mobility group box one (HMGB1) were influenced by the suppression of TLR4 the data collected was conflicting. Study 3 showed that (+)-naloxone and (+)-naltrexone …
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Effects of dietary macronutrient composition and exogenous neuropeptide Y on adipose tissue development in broiler chicks
… A high-carbohydrate (HC), high-fat (HF) or high-protein (HP) diet was fed to broiler chicks in all experiments and various facets of physiology were evaluated at day 4 post-hatch, including diet-, fasting-, and neuropeptide Y-induced effects on gene expression, cellular morphology, and lipid …
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