Global ETD Search
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Showing 1 to 2 of 2 for “"fate switching"”.
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Multiscale Modeling Of Cell Fate Switching To Predict Patient-Specific Response To Combination Cancer Therapy
All cells in the human body share the same DNA sequence, but differ in their functional identity, guided by a wide array of regulatory mechanisms controlling cellular lineage commitment and encoded in the unique epigenome of each cell type. Recent experimental studies with induced pluripotent stem …
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Pioneer Factors Compete for Epigenetic Factors in Switching Stem Cell Fates
… progenitor cells can activate one cell fate while simultaneously silencing another, a process that is tightly regulated in adult tissues. However, this process is often derailed in diseases such as cancers, leading to uncontrolled growth and malignancy. At the crossroads of …