Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"fate specification"”.
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Transcription factor Pax6 protects mouse cortical cell fate specification
… the hypothesis that Pax6 protects cortical PC specification by inhibiting interneuron-inducing signals.
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Developmental Patterning and Cell Fate Specification in the Mouse Colon
Despite being only a single cell thick, the epithelium of the mammalian colon exhibits a remarkable degree of organisation. The epithelium is highly invaginated into glandular structures. These “crypts” provide the niche for the stem cells of the epithelium. Not only do such structures form during …
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Temporal and spatial controls of cell fate specification in the cerebellum
… of Atoh1 is regulated independently from the specification of rhombic lip derivatives, suggesting a novel role for both Atoh1 and FGF signalling in rhombomere1. Analysis of triple knockout FGF receptor mutants and FGF hypomorph mice confirmed the results of dominant negative overexpression in …
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Auxin coordinates cell division and cell fate specification during lateral root initiation
Met behulp van hun wortels zijn planten in staat zich te verankeren in de bodem, waar ze ook dienen voor de opname van water en nutriënten en verankering in de bodem. Het volume bodem dat door de wortels efficiënt gebruikt wordt, hangt in sterke mate af van de complexiteit van het wortelsysteem. De …
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Neuroblast lineage and cell fate specification in the Drosophila central nervous system
The generation of cellular diversity during early development of nervous system is poorly understood. In the Drosophila central nervous system, cell diversity is primarily generated by the invariant lineage of neural precursors called neuroblasts. It has been proposed that a class of genes are …
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Regulation of fate specification in stem cells of the planarian Schmidtea mediterranea
… planarian Schmidtea mediterranea that undergo fate specification to produce over 125 adult cell types. Fate specification in neoblasts can be regulated through expression of fate-specific transcription factors. We utilize multiplexed error-robust fluorescence in situ hybridization (MERFISH) and …
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Transcriptional Regulation of Neuronal Fate Specification by Proneural Genes in the Developing Neocortex
… and Ascl1 in specifying a subcerebral layer V fate (Ctip2+, Fezf2+), while repressing layer VI (Tbr1+) and upper layer II-IV (Satb2+) identities (Chapter 2). This work expanded our knowledge of Neurog2’s role in neuronal subtype specification and identified a new role for Ascl1 in specifying …
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The rhinoceros gene of drosophila restricts cell fate specification in the developing eye
… the correct number and identity of cell fates. Among the signaling pathways that regulate cell fate determination in the developing eye, RTK/Ras/MAPK is among the most important. One effect of RTK/Ras/MAPK signaling is to downregulate the transcription factor Yan, thus allowing …
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The role of the C. elegans transcription factor LIN-11 in cell fate specification
… cells that could take on their developmental fate. These cells were believed to be responsible for the inability of hermaphrodites homozygous for a lin- 11 mutation to form a functional vulva. The results show that ablated hermaphrodites homozygous for a lin-11 mutation are rarely able to lay …
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Regulation of growth, patterning and cell fate-specification during imaginal disc regeneration in drosophila
… orchestration of growth, patterning and cell-fate specification. Drosophila melanogaster larval tissues have recently emerged as a useful model organism to study this process. These larval tissues are simple but experience complex gene expression to finally form the adult tissue. As such, …
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Cell Fate Specification and the Regulation of RNA-dependent DNA Methylation in the Arabidopsis Root Meristem
… a lot of information is known regarding the cell fate decisions that occur at the RAM, cortex specification and differentiation remain poorly understood. In the first part of this thesis, I used an ethylmethanesulfonate (EMS) mutagenized marker line to perform a forward genetics screen. The goal …
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The <i>Drosophila</i> T-box Transcription Factor Midline Functions within the Insulin/AKT and c-Jun-N-terminal Kinase Signaling Pathways to Regulate Interomatidial Bristle Formation and Cell Survival
… have identified <em>mid</em>’s role in cell fate specification of sensory organ precursor cells in conjunction with the Notch-Delta signaling pathway (Das et al., 2013). The Notch, InR, and JNK signaling pathways regulate dFOXO activity under conditions of stress. Thus, we determined the …
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The Role for Proteoglycans in Regulating Embryonic Patterning and Morphogenesis
… morphogens regulate embryonic patterning, cell fate specification, cell migration and morphogenesis. The activity and behaviour of these signalling molecules is regulated in the extracellular space through interactions with proteoglycans. Proteoglycans are high molecular-weight proteins …
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Rb pathway and chromatin remodeling genes that antagonize let-60 Ras signaling during C. elegans vulval development
… redundantly to regulate Ras-mediated vulval cell fate specification in the nematode Caenorhabditis elegans. The class B synMuv gene lin-35 encodes a protein similar to the mammalian pRb tumor suppressor protein. The LIN-35 Rb protein is proposed to act with HDA-1, a histone deacetylase homolog …
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Elucidating the Role of Cellular Architecture in the Developing Pancreas
… instruct the step-wise acquisition of β-cell fate in the developing pancreas, with the intention of recapitulating the events necessary in order to generate these cells in vitro for replacement therapies. Directed differentiation protocols have improved upon transitioning from 2D to 3D …
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Investigating the Transcriptional Regulation of PTF1A and the Function of PRDM13 to Specify Dorsal Spinal Interneurons
… is a fundamental process required for cell fate specification. During neural development, complex interactions of diverse transcription activators and repressors regulate lineage specific programs. The multitudes of neuronal subtypes generated during development is dependent on …
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The Identification of the Mid Transcription Factor Regulatory Network Specifying Cell Fate and Regulating Survival in the <i>Drosophila</i> Eye
… Tbx-20. Both Mid and Tbx-20 regulate cell-fate specification with in diverse tissues including the central nervous system (CNS) and heart. Although, some important studies reported that Tbx-20 transcripts express in a wide range of developing mammalian eye tissues including those of the …
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How, when, and where: fate selection in regenerative planarians
… in planarians is regulated by the expression of fate-specific transcriptions factors (FSTFs) in dividing cells called neoblasts. However, it remains unclear whether all ~150 fate choices are made in neoblasts, or whether additional mechanisms for generating cell type diversity are used. We used …
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