Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"fate choice"”.
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The physics of cell-fate choice
… the zygote--- and acquire the various cell fates seen in adult organisms. The different cell types are characterized by distinct, cell-fate-specific gene expression patterns. Cells of different types can also exhibit varying metabolic states depending on their intrinsic needs and the …
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Extrinsic regulation of fate choice in mouse haematopoietic stem cells
Extrinsic regulation of fate choice in mouse haematopoietic stem cells The mechanisms regulating stem cell self-renewal, proliferation, and differentiation are still not fully understood. Improving our knowledge of these processes will not only provide greater insight into stem cell biology but …
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From coarse fate choice to precise pattern: post-mitotic progenitor targeting
Planarians possess remarkable regenerative abilities, driven by pluripotent stem cells called neoblasts. While neoblasts are known to give rise to progenitor cells that form various tissues, whether and the extent to which these progenitors migrate across the animal remains unclear. Irradiation …
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The effect of aging on myelinating gene expression and oligodendrocyte cell densities
… to differentiate into astrocytes, with this fate choice occurring following cytoplasmic translocation of Olig2. These data reveal for the first time age-related differences in the differentiation of PDGFαR+ve progenitor cells into OLs and astrocytes and lead me to suggest that during aging …
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Dynamics of Cell Fate Decision Making Between Sporulation and Competence in Bacillus Subtilis
… differentiation cells must reliably make a cell fate decision under a variety of conditions, yet remain sensitive to changes in extracellular environment. It is unclear how the cells reconcile these seemingly contradictory requirements. To complicate the issue, the cells often face a decision …
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How, when, and where: fate selection in regenerative planarians
… in planarians is regulated by the expression of fate-specific transcriptions factors (FSTFs) in dividing cells called neoblasts. However, it remains unclear whether all ~150 fate choices are made in neoblasts, or whether additional mechanisms for generating cell type diversity are used. We used …
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Regulation of fate specification in stem cells of the planarian Schmidtea mediterranea
… planarian Schmidtea mediterranea that undergo fate specification to produce over 125 adult cell types. Fate specification in neoblasts can be regulated through expression of fate-specific transcription factors. We utilize multiplexed error-robust fluorescence in situ hybridization (MERFISH) and …
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The Role of Meis1 in Hematopoietic Development
… transition: EMT) and of cardiovascular cell fate in differentiating embryonic stem cells: ESCs). To understand the molecular mechanisms underlying the actions of <italic>Mesp1</italic>, we sought to identify transcription targets of <italic>Mesp1</italic>. <italic>Mesp1</italic> rapidly …
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Uncovering molecular mechanisms of the notch signaling pathway in the regulation of pituitary gland development
… pathways that are necessary for pituitary cell fate determination can result in pituitary disorders such as hypopituitarism, which is associated with several detrimental health conditions including growth deficiencies, adrenal insufficiency, infertility, and hypothyroidism. To understand the …
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A phagocyte-specific Irf8 gene enhancer establishes early conventional dendritic cell commitment
… Irf8 expression, subsequently to disturbed cell fate decisions, demonstrating the importance of these factors for proper phagocyte cell development. Collectively, these data delineate a transcriptional program establishing cDC fate choice with IRF8 in its center.
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Role of Notch Signaling and GATA-3 in Establishing T-lineage Commitment and Survival in Developing Thymocytes
… factors such as GATA-3 to fully induce this fate choice while inhibiting the B-cell lineage. Although both Notch and GATA-3 are indispensible for thymocyte development, their precise roles in directing these events remain to be elucidated. Examining such phenomena during ontogeny has been …
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Investigating neuroectodermal transdifferentiation: How do CNS progenitors form Schwann cells?
… underlying this damage-induced plasticity of OPC fate choice remain incompletely understood. Therefore, in this thesis I sought to understand how changes in the lesion environment alter the differentiation trajectories of individual OPCs, and to determine how these factors affect the …
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pRb's role in cell fate, lineage commitment, and tumorigenesis
… or Rb re-activation was sufficient to switch the fate commitment of osteosarcoma tumor cells in vitro through direct regulation of transcription factors that control mesenchymal differentiation. Consistently, we found that reactivation of Rb in tumors generated from Rb;p53 DKO cells was sufficient …
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Activation of developmental signaling pathways in hematopoietic stem cell regeneration
… we discovered Notch activated cells change their fate choice during regeneration. To determine if Notch gain of function provides radio-protection we infected stem cells with an active form of Notch prior to radiation and then scored self renewal potential in vitro. This led us to the conclusion …
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Novel roles of KAT2A chromatin complexes ATAC and SAGA in normal and malignant haematopoiesis
… been an attractive model to explore how cell fate decisions are conducted at the molecular level, to generate the vast diversity of blood cell types. Blood cell fate choice is for the most part regulated by transcription factors and epigenetic modifiers. The enzymatic activities of epigenetic …
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The role of the mechanical microenvironment in regulation of cholangiocyte specification and tubulogenesis
… of the extracellular matrix (ECM) on cell fate and functionality associated with ageing, development and disease (Segel et al. 2019; Bansaccal et al. 2023). Despite most studies emphasising ECM stiffness, recent insights suggest a cooperative role of ECM ligand composition and stiffness in …
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Computational reconstruction of mouse development using single cell transcriptomics
… associated with cell differentiation and fate choice. Longitudinal cohort studies, ideal for capturing the dynamic nature of developmental mechanisms delineate the temporal relationship between cell type diversity and developmental dynamics. The efforts to build cell atlases from different …
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Mechanical mapping of lineage boundaries in the developing Xenopus laevis embryo
… and must regularly make decisions between these fates. While we have a good understanding of how the chemical environment influences these decisions, there is mounting evidence that stem cells integrate mechanical and chemical signals *in vitro* when making fate decisions. Specifically, substrate …
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Identifying Novel Molecular Mechanisms Underlying Lateral Line Organ Development in Sterlet
… the system a useful model to investigate cell fate decisions during development. Electroreception was lost in the lineages leading to teleost ray-finned fishes and frogs, so the electrosensory (AO) vs. mechanosensory (neuromast) fate-choice cannot be studied in the standard anamniote models, …
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