Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"fast-spiking"”.
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The role of fast-spiking interneurons in cortical map plasticity
… which I have tested in this thesis. I focused on fast-spiking (FS) interneurons, which are thought to play an important role in<br/>adult cortical plasticity. I made electrophysiological recordings in layer 2/3 to determine how inhibitory circuitry in deprived cortex is affected by whisker …
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Causal evidence for the behavioral impact of oscillations in neocortex and hippocampus
… behaving mice. By rhythmically stimulating fast-spiking interneurons in somatosensory cortex, I can emulate the activity patterns that define gamma oscillations under natural conditions. Emulating gamma enhances the detection of threshold-level vibrissae deflections, analogous to the …
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Anoxia-Mediated Electrical Suppression in the Cerebral Cortex of the Western Painted Turtle (Chrysemys picta bellii): Role of the Mitochondrion
… oxygen species results in increased activity in fast-spiking GABAergic interneurons and elevated extracellular [GABA]. Together, this research contributes to our understanding of neuroprotective mechanisms in anoxia-tolerant organisms and demonstrates the importance of mitochondrial function …
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Scalable Bundle Design for Massively Parallel Neuronal Recordings <i>In Vivo</i>
… can sample at a temporal resolution to resolve fast spiking neurons. If scaled to a sufficiently large number of simultaneous recorded neurons, this technique would be an excellent candidate for such large scale recording. I propose the combined use of glass ensheathed microwire bundle …
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Longitudinal tracking of neural vascular recovery post microinfarct using multimodal neural platform
… single neurons revealed that the excitability of fast-spiking narrow interneurons is dampened the most among all cell types during this minor ischemic induction and recovery process. Thirdly, we found that neuronal damage is depth-related, with shallower layers being more severely affected than …
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Gamma frequency entrainment attenuates amyloid load and modifies microglia
… are generated by a resonant circuit between fast-spiking (FS)-parvalbumin (PV)-interneurons and pyramidal cells. Changes in gamma oscillations have been observed in several neurological disorders. However, the relationship between gamma oscillations and cellular pathologies of these disorders …
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Large-scale neural recordings and biophysical models for inferring network mechanisms of ketamine anesthesia
… neural activity. Furthermore, I demonstrate that spiking UP-states that underlie gamma bursts wax and wane in a synchronous fashion across the majority of the neocortex, entraining local field potentials in the intralaminar thalamus, a major subcortical regulator of arousal. While cortical gamma …
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The Role of Perineuronal Nets in Regulating Barrel Cortex Physiology
… increasing action potential amplitude in fast spiking (FS) inhibitory interneurons; 3) enzymatic digestion of PNNs only mildly impac spike frequency and firing probability, but significantly reduces input resistance, and spike amplitude in FS inhibitory interneurons and 4) Perturbation of …
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Mechanisms of ocular dominance plasticity in the juvenile and adult mouse visual cortex
… and demonstrate that parvalbumin-expressing fast-spiking basket cells are specifically implicated in the absence of juvenile-like deprived-eye depression in adult mice.
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Pitx3Null Mutant (Striatal Dopamine-Deficient) Mice Have Exaggerated Spiny Projection Neuron Responses to l-DOPA and D1 Agonism and Lack Baseline Striatonigral Spiking
… (SPN) spike rates, SPNs <em>should </em>increase spiking during the motor response to l-DOPA. In fact, stimulating specific subsets of these neurons to spike in freely-moving wild type and parkinsonian animals causes or inhibits motor activity as predicted. However, pharmacological effects of DA …
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Selective Neuronal Vulnerability in Neocortices from Patients with C9ORF72-related Neurodegeneration
… doing, upper layer excitatory subtypes, PVALB+ fast-spiking basket interneurons, and specific VIP+ interneurons were identified as vulnerable. Transcriptomic changes primarily manifested in neurons as altered mitochondrial, proteostatic, and synaptic function. Minimal evidence of glial …
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Mechanisms underlying neural circuit remodeling in Toxoplasma gondii infection
… also has tropism, and moreover, are rich with fast-spiking parvalbumin perisomatic synapses, a type of GABAergic synapse whose dysfunction has been implicated in epilepsy and schizophrenia. By employing a range of visualization techniques to assess cell-to-cell connectivity and neuron-glia …
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Systematic examination of the impact of pre-stimulus alpha- mu and gamma band oscillations on perception : correlative and causal manipulation in mouse and human
… stimulus. Then using optogenetic control of the fast-spiking interneurons, we causally entrain a gamma oscillation to show enhancement of perception.
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Striatal Microcircuits Underlying Control of Actions
… as a behavioral variable, but it is unclear how fast the animal moved, in what direction, or what effectors were used. The following experiments were designed to investigate the role of striatal neurons in controlling movement velocity in mice. The first set of experiments (Chapter 2) examined …