Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"fast scan cyclic voltammetry"”.
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Improving Fast-Scan Cyclic Voltammetry and Raman Spectroscopy Measurements of Dopamine and Serotonin Concentrations via the Elastic Net
… in a human brain using a technique known as fast-scan cyclic voltammetry, for example from patients undergoing deep brain stimulation (DBS) electrode implantation surgery. In this work, we aimed to assess the feasibility of obtaining veridical dual measurements of serotonin and dopamine from …
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THE EFFECTS OF SOCIAL STRESS AND PRIOR ETHANOL EXPOSURE ON DOPAMINE IN THE RAT BRAIN
… or experiment. The current thesis uses in vitro fast-scan cyclic voltammetry to examine the effects of social defeat stress and chronic ethanol exposure on ethanol-induced dopamine changes in key structures of these two dopaminergic pathways, the nucleus accumbens core and dorsolateral striatum. …
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REGULATION OF DOPAMINE TERMINAL RELEASE IN THE NUCLEUS ACCUMBENS: IMPLICATIONS FOR ALCOHOL ADDICTION
… signaling in nucleus accumbens slices with fast scan cyclic voltammetry allows for pharmacological assessment of dopamine terminal release regulation and has provided a wealth of information regarding how drugs of abuse affect dopamine terminal function. However, this experimental approach …
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Development Of Single And Array Electro-Chemical Sensors For Real-Time Trace Metal Analysis In Aqueous Environmental Media
… concerns. Recently, we developed a method using fast-scan cyclic voltammetry (FSCV) at carbon-fiber microelectrodes (CFMs) to achieve rapid measurement of metal ions with high sensitivity, selectivity, and stability. Through optimizations this method showed strengths in real-time trace metal …
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Improving dopamine monitoring with NCAM and the effects of intranasal oxytocin on dopamine signaling in the rat brain
… has also been implicated in learning and memory. Fast-scan cyclic voltammetry (FSCV) is a method used for the real-time examination of DA neurotransmission in the brain. Implanting FSCV electrodes is an invasive technique that likely results in an inflammatory response (i.e. gliosis) that can …
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Novel Electrochemical Methods for Human Neurochemistry
… Montague Laboratory and collaborators adapted fast scan cyclic voltammetry (FSCV) from rodent experiments for use in human patients already receiving brain surgery. The process of modifying established FSCV methods for clinical application has led improved model building strategies, and a new …
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Neurochemical Measurements in Rodents that Model Huntingtion's Disease and Oxidative Stress
… and extensive striatal degeneration. We used fast-scan cyclic voltammetry to measure dopamine release and reserve pool dopamine in genetically and chemically altered rodents that model HD. Genetic HD model mice and rats (R6/1 mice, R/2 mice, and HDtg rats) showed an age-dependent decrease in …
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Long-term characterization of the chronic dopamine microelectrode and effect of electrical conditioning
… in movement, reward learning and addiction. Fast-scan cyclic voltammetry (FSCV) has long been an indispensable tool for monitoring real-time DA signaling. Development of polyimide fused silica-encased FSCV microelectrodes have made the technique more suitable for chronic DA monitoring …
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Effect of low endogenous brain-derived neurotrophic factor levels on striatal dopamine dynamics
… neurochemical techniques, slice (in vitro) fast scan cyclic voltammetry (FSCV) and in vivo microdialysis were used to characterize striatal DA dynamics in wildtype and BDNF heterozygous mutant (BDNF+/-) mice. </p> <p>Overall, our findings highlight that (1) we were able to develop a reliable …
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Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball
… of this neurochemical synergism, in vivo fast-scan cyclic voltammetry (FSCV) was used to compare evoked DA release and DA transporter (DAT)-mediated reuptake kinetic parameters following acute administration of cocaine, heroin and speedball in drug-naïve rats, as well in rats with chronic …
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A Novel, Ultra-Fast Electrochemical Tool To Study Speciation Of Trace Metals In Aqueous Solution
… to the challenge of analysis in real systems. Fast scan cyclic voltammetry is explored in the context of rapid, minimally invasive and robust analysis of Cu2+ and Pb2+ in aqueous samples with carbon fiber microelectrodes. Unique Cu2+-specific and Pb2+-specific waveforms were generated with …
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Development Of Carbon Based Neural Interface For Neural Stimulation/recording And Neurotransmitter Detection
… for peripheral nerve stimulation. </p> <p>Fast scan cyclic voltammetry is an electrochemical detection technique suitable for in-vivo neurotransmitter detection because of the miniaturization, fast time response, good sensitivity and selectivity. Traditional single carbon fiber …
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The effects of chronic intermittent ethanol exposure on withdrawal related behaviors, dopamine terminal function and kappa opioid system sensitivity in the nucleus accumbens core
… of accumbal dopamine transmission with fast scan cyclic voltammetry in brain slices showed reduced dopamine release, augmented uptake and increased sensitivity of KORs and D3Rs following five weeks of CIE exposure. A subsequent examination of interactions between KORs and dopamine …
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Striatal Dopamine Dynamics Upon Manganese Accumulation
… the Mn-treated animals. The first study used fast scan cyclic voltammetry, microdialysis, and tissue content analysis to characterize the dopamine system after the sub-acute treatment protocol. Behavioral tests were subsequently used to elucidate any phenotypic differences in the treated mice …
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The influence of anesthesia and nicotine on dopamine signaling in the rat dorsal striatum
… striatum) reward learning (ventral striatum). Fast-scan cyclic voltammetry (FSCV) is a technique that uses microelectrodes (diameter ~5 μm, length ~150 μm) to monitor dopamine signaling in the brain. Although urethane and isoflurane anesthetics are commonly used in in vivo studies, isoflurane’s …
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Multimaterial multifunctional fibers for biomedical applications
… and disorders. The most adapted methods are fast scan cyclic voltammetry and microdialysis. However, both have some limitations such as offline sensing or lack of selectivity. Furthermore, by concentrating optical fields at the nanoscale, plasmonic nanostructures can serve as optical …
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Investigation Of Dopamine Dynamics In Bdnf+/- Mice Using In Vivo Microdialysis And Electrochemical Analysis Of Purine And Monoamine Molecules Using A Boron-Doped Diamond Electrode
… series of <i>in vivo</i> microdialysis and slice voltammetry experiments, we have discerned that female BDNF<sup>+/-</sup> mice are hyperdopaminergic similar to their male BDNF<sup>+/-</sup> counterparts. The <i>in vivo</i> microdialysis method zero-net flux highlighted that female …
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Evaluation Of Presynaptic Dopamine Dynamics After: Toluene Inhalation Or Trkb Receptor Activation
… and neurochemical techniques such as slice fast scan cyclic voltammetry (FSCV), in vivo microdialysis, and brain tissue content analysis to examine how toluene inhalation alters the striatal DA system. Overall, both behavior and neurochemical data confirmed that toluene inhalation alters …
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In-situ spectroelectrochemical surface studies of fundamental fuel cell catalysis
… results required clarification with the use of fast-scan cyclic voltammetry. Acetaldehyde oxidation in alkaline electrolytes shows unique CO behavior that is not observed in ethanol oxidation in the same electrolyte, adding further evidence that acetaldehyde is not a long-lived intermediate in …
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The Effect Of An Intermittent Manganese (ii) Exposure On The Striatal Dopamine System
… were used: ex vivo tissue content, in vitro fast scan cyclic voltammetry, in vivo microdialysis, and graphite furnace atomic absorption spectroscopy. The results demonstrate a bi-phasic striatal DA response depending on the dose of Mn administered.</p> <p>More specifically, the low dose of Mn …
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