Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"fasciculation"”.
-
Balancing growth and repulsion: Slit proteolysis generates diverse signals in axon guidance
… by promoting axon growth, branching, and fasciculation. Slit-N appears to only act as a repellent at higher than endogenous concentrations. Despite these early findings, the majority of subsequent studies have used Slit-FL and Slit-N as interchangeable repellents. In Chapter 2, we clarify …
-
Axon guidance in the zebrafish visual system: Analysis of Esrom Mutant
… mutant esrom shows that it is required for axon fasciculation, targeting, branching and skin pigmentation. In the visual system esrom is necessary for the formation of topographic map along the A-P and D-V axis, correct innervation of the pretectal targets and axon bundling in the optic tract. …
-
Quantitative analysis of axon elongation : a novel application of stochastic modeling techniques to long-term, high-resolution time-lapse microscopy of cortical axons
… such as elongation, turning, branching, and fasciculation, all in service of the complex goal of wiring up the brain. In order to quantify these behaviors, I have developed a system for in vitro imaging of axon growth cones with time-lapse fluorescence microscopy. Image tiles are …
-
Inhibition of Retinoic Acid Receptors Results in Defasciculation of the Trigeminal Nerve in Xenopus laevis
… is downregulated just prior to the observed defasciculation phenotype. The pattern of expression of these genes combined with known expression of NT-3 receptors allows us to suggest a model whereby RA signaling regulates Sema4B, ALCAM and NT-3, which support the survival, guidance and …
-
Novel EphB Receptor Forward Signaling Pathways in the Development of Major White Matter Tracts of the Mammalian Brain
… during their development through a selective fasciculation event. Together, these findings represent a major step forward in the understanding of axon connectivity in specific regions of the mammalian brain and also highlight the widespread function and importance of EphB receptors and …
-
Γονιδιακή κλωνοποίηση μορίου κυτταρικής συνάφειας του νευρικού συστήματος
… differentiation, cell aggregation, growth and fasciculation of axons, synaptic connections). In this work, LN-10 cell adhesion molecule (chick) has been cloned with the use of heterologous cDNA probe (rat). The LN-10 molecule is expressed specifically in the chick nervous system (cerebellum, …
-
The Molecular Regulation of Spinal Nerve Outgrowth
… properties of somites and in axon guidance and fasciculation. I focused on the functional analysis of one molecule of the posterior half-sclerotome, the extracellular matrix protein Fibulin-2. To look at its role in the segmentation of spinal axons, I used ectopic misexpression in a subset of …
-
The mechanical regulation of Eph/ephrin signalling in the developing Xenopus brain
… how substrate stiffness affects axon fasciculation independently of chemical cues, I developed an in vitro assay combining stiffness gradient hydrogels and micropatterning. Since Eph/ephrin signalling in Xenopus RGCs is affected by substrate stiffness in vitro, and a stiffness gradient …
-
Structure of the Chicken Neuron-Glia Cell Adhesion Molecule, Ng-CAM: Origin of the Polypeptides and Relation to the Ig Superfamily
… adhesion, neuron-glia adhesion, neurite fasciculation, and neuronal migration on glial cells. This thesis describes the characterization of cDNA that encode the entire Ng-CAM protein and the determination of the origin of the polypeptide components. An analysis of the deduced amino acid …