Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"familial breast cancer"”.
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Assessing risk of familial breast cancer: effectiveness of current UK guidelines
Breast cancer risk is a common indication for referral to clinical genetics. National Institute of Health and Care Excellence (NICE) guidelines use family history to stratify patients by 10-year risk of breast cancer from the ages 40-49. Patients are divided into low (10-year risk <3%), moderate …
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Identification of low-penetrance alleles, genetic modifiers and mutation analysis in familial breast cancer cases
… are responsible for approximately 30- 35% of breast cancer familial clustering, leaving the majority of them unexplained. In addition, the variability of the risk conferred by <i>BRCA1</i> and <i>BRCA2</i> mutations suggests the presence of genetic modifiers of this risk. Therefore, the …
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Consequences of telomerase inhibition and telomere dysfunction in BRCA1 mutant cancer cells
… account for approximately half of all hereditary breast and ovarian cancers, and the gene is silenced via promoter methylation and loss of heterozygosity in a proportion of sporadic breast and ovarian cancers. The objective of this study was to determine whether GRN163L, a telomerase inhibitor, …
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Molecular Epidemiology of Breast Cancer
Hereditary breast cancer constitutes a considerable fraction of the total number of breast cancer cases occurring each year. Up until recently very few breast cancer predisposing genes were known, but many new common polymorphisms contributing to increased cancer susceptibility are continuously …
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Identifying New Genes for Inherited Breast Cancer by Exome Sequencing
Breast cancer is the most common cancer among American women and family history is an important risk factor for its occurrence. More than 20 genes have been identified with inherited mutations that lead to significantly increased risk of breast cancer. However, most familial breast cancer is not …
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Analysis and confirmation of the results of a yeast two-hybrid screen carried out to identify proteins that interact with drosophila XRCC2
… and strand transfer. The proteins encoded by the familial breast cancer genes, brcal and brca2, also play an important role in HRR.</p> <p>My project is concerned with studying proteins that interact with <em>Drosophila melanogaster </em>(XRCC2). Proteins interacting with DmXRCC2 were identified …
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Breast Cancer Risk For Female Relatives of Male Breast Cancer Patients With Negative Brca1/2 Testing
… exist to estimate a female’s lifetime risk of breast cancer in the absence of a hereditary predisposition to cancer, namely Hereditary Breast and Ovarian Cancer syndrome. These risk models consider various factors such as reproductive history and family history, but few models take a family …
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Insights into breast cancer: New familial patterns and identification of a potential predictive marker
The last proportion of heredity in breast cancer has proven to be somewhat elusive despite massive attempts to identify the associated factors. Approximately 50 percent of breast cancer caused by familial factors is currently explained. The five-year survival for breast cancer patients is …