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Showing 1 to 11 of 11 for “"factor XIII"”.

  1. Roles of coagulation factor XIII in the functions of blood platelets

    Magwenzi, Simbarashe G.Hull York Medical School, the University of Hull and the University of York2011

    Activated blood coagulation factor XIII (FXIIIa) is a transglutaminase that stabilises fibrin clots and associates with platelets. In the present study, the role of factor XIII (FXIII) in modulating physiological platelet functional responses including adhesion, signal transduction and spreading …

    hull Repository record

  2. Roles of coagulation factor XIII in the functions of blood platelets

    Magwenzi, Simbarashe G.Hull York Medical School, the University of Hull and the University of York2011

    … of blood platelets and soluble coagulation factors in forming blood clots at sites of vascular injury. Platelets are recruited from flowing blood and become activated to fulfil their haemostatic roles (Marcus, 1969, Ruggeri and Mendolicchio, 2007). Coagulation factors are also spatially …

    hull Repository record

  3. Gene transfer of keratinocytes with a human Factor XIII - plasmid construct

    Horváth, Laura

    Factor XIII (plasma transgutaminase) is essential to the clotting process. It catalyses the cross-links between the fibrin monomers, in consequence of the forming fibrin clot achieves an improved stability and a high fibrinolysis resistance. This provides a provisional matrix for the cell migration …

    freiburg-diss Repository record

  4. Assessing gene expression of coagulation factors and Factor XIII polymorphisms in type 2 diabetes mellitus patients

    University of Pretoria2018

    … was to assess the mRNA levels of coagulation factors and the identification of two FXIII SNPs (Val34Leu and Tyr204Phe) in T2DM patients (n=100) compared to controls (n=100). Methodology: Thromboelastography (TEG) was used to assess the viscoelastic properties of pre-selected clot parameters. …

    pretoria Repository record

  5. Viscoelastic haemostatic assays and fibrinogen concentration tests during haemodilution: The effects of fibrinogen and factor XIII

    Winstedt, DagAnaesthesiology and Intensive Care2014

    … The efficacy of concentrates of fibrinogen and factor XIII in hypothermia and haemodilution has not yet been completely investigated. Clauss methods have not previously been evaluated perioperatively. Methods: Coagulation was assessed with rotational thromboelastometry (ROTEM) or free …

    lund Repository record

  6. Evaluation of the Role of Endogenous Factor XIII as a Determinant of Bleeding-Related Outcomes and Death Among Severely Injured Patients

    Gomez Builes, Johana Carolina2025

    … by reducing clot destruction with coagulation factors such as factor XIII (FXIII). Lower serum FXIII levels can cause reduced clot stability and premature clot breakdown. We hypothesize that lower FXIII levels result in worse bleeding-related outcomes and death. To test the hypothesis, we first …

    toronto-retro Repository record

  7. Coagulation Factor XIII (FXIII) and Vascular Endothelial Growth Factors VEGF and VEGF-C Produced by Platelers : From Clinical Findings to Molecular Characteristics

    Wartiovaara, UllaHelsingin yliopisto1999

    helsinki Repository record

  8. An integrated process for the recovery of clinically significant trace proteins from human plasma

    Benny, Athol GraemeResearchSpace@Auckland1990

    Methods for the preparation of concentrates of factor VIII, factor IX, high purity factor IX, Cl esterase inhibitor, specific immunoglobulin and platelet factor XIII are described. These procedures were developed or modified with the aim of integration into an automated process that would allow …

    auckland-ms Repository record

  9. Autologous Fibrinogen Purification and Concentration For Use in Fibrin Sealant

    Alston, Steven M.2005

    … In addition, it was shown that almost 50% of the factor XIII in the plasma was also precipitated along with the fibrinogen. The tensile and adhesion strengths and kinetics of fibrin sealant prepared from protamine-fibrinogen concentrate were evaluated. Tensile strength and adhesion strength both …

    byu Repository record

  10. Proteases of the neutrophil membrane represent an alternative fibrinolytic pathway to that mediated by plasmin

    Adams, Susan AnnUCT/MRC Liver Research Centre1996

    … products in a process dependent on calcium and factor XIII. The reformed products have a similar molecular weight to those produced by plasmic lysis of fibrin, as well as a putative crosslinked site. However, the isoelectric point of these reformed products indicates they are distinctly …

    cape-town Repository record

  11. Design, Synthesis and Evaluation of Covalent Inhibitors for Tissue Transglutaminase and Factor XIIIa

    Akbar, AbdullahUniversité d'Ottawa / University of Ottawa2019

    … human tissue transglutaminase (hTG2) and human factor XIIIa (FXIIIa). Divided into two projects for each enzyme, the main objective of this thesis was directed towards the discovery of potent and selective covalent inhibitors for each isozyme, namely hTG2 and hFXIIIa. The first project was …

    ottawa-retro Repository record