Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 129 for “"factor I"”.
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Regulation of IGFBP-5 and Osteoblast Functions by Nuclear Factor I
The Insulin-like Growth Factor (IGF) system is a major target of GC inhibition in bone. We found that GCs inhibit expression of IGF binding protein-5 (IGFBP5) which binds IGFs and stimulates osteoblast activity by IGF dependent and independent mechanisms. GC-induced inhibition of IGFPB5 promoter …
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The Role of Insulin-Like Growth Factor-I in Myeloid Cell Differentiation
… as a survival as well as a differentiation factor during both RA and vitamin D$\sb3$-induced myeloid differentiation processes.
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Nutritional Regulation of Serum Insulin-Like Growth Factor-I Concentration in Cattle
… mechanisms by which serum insulin-like growth factor-I (IGF-I) is regulated by nutritional intake in cattle. Two studies were conducted to achieve this objective. In the first study, effects of feeding levels on basal and growth hormone (GH)-stimulated serum concentrations of IGF-I, IGF binding …
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Characterization of insulin-like growth factor-I system gene expression in pcd mice
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Growth Hormone and Nutritional Regulation of Insulin-Like Growth Factor-I Gene Expression
… were to characterize insulin-like growth factor-I (IGF-I) gene expression in cattle, to determine how IGF-I gene expression is affected by nutritional intake and growth hormone (GH) in cattle, and to identify the regulatory DNA region that mediates GH stimulation of IGF-I gene expression. …
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Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells
… other well-known hematopoietic transcription factors, including pSTAT1, RUNX1, RAD21, STAT3, ETO2, FLI1, GATA2, LYL1, LDB1 and PU.1. We showed NFIX and PU.1 together target genes regulating hematopoietic cell adhesion, cell death and differentiation in hematopoietic cells. Our data support a …
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Genetic, molecular and functional analyses of factor I - an inhibitor of the complement system
Factor I (FI) is a serine protease that inhibits the complement system by cleaving activated C3 and C4 complement proteins, in the presence of cofactors. Mutations in the gene coding for FI have been identified in complete FI deficient- and atypical hemolytic uremic syndrome (aHUS) patients. The …
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The oxidative folding of insulin-like growth factor-I analogues / by Steven John Milner.
This thesis investigates the effect of mutations and an N-terminal extension on the oxidative folding pathway of IGF-I, analyses the structure of the stable mis-folded molecule in terms of its biological interactions, examines the kinetics of the late stages of oxidative folding and finally …
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Cloning and characterization of ovine insulin, insulin-like growth factor-I and -II genes
Genes encoding ovine insulin like growth factor-I (oIGF-D), -II (oIGF-II) and insulin were cloned, sequenced and characterized. The olGF-I gene contains six exons spanning greater than 30 kilobases. Class 1 and class 2 oIGF-I transcripts contained exons 1 and 2 alternatively-spliced to exon 3, …
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Mechanisms of Growth Hormone Regulation of Insulin-Like Growth Factor-I Gene Expression in Liver
… hormone (GH) regulates insulin-like growth factor-I (IGF-I) gene expression in liver. Previous studies have suggested that GH regulation of IGF-I gene expression in liver is mediated by binding of the transcription factor signal transducer and activator of transcription (STAT) 5 to four …
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Oral Insulin-Like Growth Factor-I and Development of the Small Intestine in the Neonatal Piglet
Given that IGF-I modulation of intestinal development did not lead to an increase in overall piglet growth, we conclude that the effects of IGF-I in the normal, healthy neonate are modest. However, since IGF-I stimulates intestinal growth and development without undesirable systemic effects, it may …
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Glucose regulation in Thoroughbred weanlings: Regulation by insulin, growth hormone and insulin-like growth factor-I
… growth hormone (GH) and insulin-like growth factor-I (IGF-I) concentrations. Insulin sensitivity, glucose effectiveness, acute insulin response to glucose and disposition index were derived using Minmod Millennium and WinSAAM software. Diet groups were compared using the non-parametric …
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Insulin-like growth factor-I in growing horses and RNA isolation from small articular cartilage samples
… synovial fluid (SF) total insulin-like growth factor-I (IGF-I) concentrations, as well as their association with measurements of skeletal growth in Thoroughbred horses. Horses were randomly assigned to one of two dietary treatment groups and fed diets with either a high or low starch content to …
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The Role of Insulin-like Growth Factor-I and IGF-binding Proteins in Mammary Gland Development
… is likely mediated by locally produced growth factors acting in concert with circulating mitogens. To investigate the importance of mammary synthesis of insulin-like growth factor-I (IGF-I) and IGF-binding proteins (IGFBP), the initial objective was to evaluate the physiological effects of …
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Another piece for the puzzle: Psychophysiological indicators of the absence of empathic responding in Factor I psychopathy
… with a biological dimension (psychopathy Factor I), who can be distinguished early in life from merely delinquent individuals. As the research literature indicates, lack of empathy seems to be a prominent marker distinguishing psychopathic reactions from other antisocial behaviours. The …
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Refining the evaluation of growth and the growth hormone/insulin-like growth factor-I axis in children
… The growth hormone (GH)/Insulin-like growth factor-I (IGF) axis is a key mediator of childhood growth. Current diagnostic tests have poor specificity for disorders affecting this system, namely the growth hormone stimulation test (GHST) and IGF-I measurement. Aim: To improve the diagnostic …
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Intestinal Development and Gene Expression of Piglets Suckling Sows Transgenic for Human Insulin-Like Growth Factor-I
… from previous studies. Insulin like growth factor-I appeared to act via the type I IGF receptor at d 21 in the ileum of piglets suckling IGF. Microarray analysis elucidated differentially expressed genes involved in proliferation, as well as genes involved in immune function and metabolism, …
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Overexpression of ovine insulin-like growth factor-I (IGF-I) in the mammary glands of transgenic mice
… by the production of insulin-like growth factor-I (IGF-I). To generate a model for investigation of the effects of enhanced IGF-I synthesis in the mammary gland, six transgenic founder mice were produced by microinjection of a cDNA sequence encoding ovine IGF-I (oIGF-I) under the control …
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Microphysiometry Studies of Rapid Binding of Insulin-Like Growth Factor I by Parental and Transfected Mammary Epithelial Cell Lines
… Members of the family of insulin-like growth factors (IGFs) are proposed to play a major role in the development and subsequent uncontrolled proliferation of breast cancer cells. Insulin-like growth factor-I (IGF-I) is known to be a potent mitogen for mammary epithelial cells. IGF-I acts by …
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Interaction of growth hormone and insulin-like growth factor-I in the control of steroidogenesis by cultured porcine granulosa cells
In order to better understand the factors controlling or modulating ovarian function, and in an attempt to develop a way to increase ovulation rate in gilts, the effects of metabolic hormones such as growth hormone (GH), insulin or prolactin and growth factors such as insulin-like growth factor I …
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