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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"factor H"”.
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Complement Factor H Related Proteins and their Biological Role During Bacterial Infection
… to meningococcal disease but further genetic factors that contribute to disease susceptibility are less well understood. A genome wide association study has linked polymorphisms in the Complement Factor H (CFH) locus with meningococcal disease in the general population. CFH is a negative …
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Genetic Factors Associated with Anti-Factor H Autoantibodies in Atypical Hemolytic Uremic Syndrome (aHUS)
… of the complement system. Autoantibodies against factor H (anti-FHs), a regulator of the AP, were reported in 10% of patients, and are associated with the deficiency of factor H related 1 (FHR1), a FH homologous protein. <br></br><br></br> The aim of this thesis was to evaluate the contribution of …
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Interaction of Bacillus Anthracis Exosporium Protein Bcla With Complement Factor H and Spore Persistence In The Lung
… can target specific proteins, such as Factor H (fH) of the complement system. Spores of <em>B. anthracis</em> are enclosed by an exosporium, which consists of a basal layer surrounded by a nap of hair-like filaments. The major structural component of the filaments is called …
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Survival strategies of the human respiratory tract pathogen Haemophilus influenzae
… the majority of the H. influenzae tested bound factor H, the inhibitor of the alternative pathway. Importantly, the capacity to bind C4BP and factor H appears to render the bacteria more resistant to serum mediated killing. Furthermore, both C4BP and factor H bound to the surface of H. …
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Effect of Sialylation of Histophilus somni Lipooligosaccharide on Virulence and Resistance to Host Defenses
… killing, binding of complement factor H (which converts C3b to inactive C3b (iC3b) and inhibit the alternative complement pathway) to the bacteria, complement activation by the LOS, and phagocytosis and killing of the bacteria by bovine polymorphonuclear leukocytes (PMN). Killing …
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Analysis of plasminogen binding to Treponema denticola, a key periopathogen
… of the human complement regulatory protein, Factor H (FH), to the factor H-binding protein (FhbB). FH serves as cofactor in the Factor-I mediated cleavage of C3b and accelerates the decay of the C3 convertase complex, leading to downregulation of C3b production. Several pathogens bind FH, and …
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Selected Learner Traits Related to Learning Interpersonal Skills: An Empirical-Descriptive Exploratory Study
… open-mindedness and ten selected factors from the Sixteen Factor Personality Questionnaire (Factors A+, B+, E+, H+, I+, L-, M+, O-, Q1+ and Q2+) and achievement in a sequence of instruction in interpersonal skills. The secondary purposes were to link these traits to a theory of …
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Characterization of Complement C3 Dysregulation Predisposing to Two Human Disease States
… mutations in the regulatory proteins Factor H, CD46 and Factor I have been shown to predispose to the disease. This is due to a lack of proper control of complement activation on endothelial cells in the renal microvasculature. The first goal of this thesis work was to characterize the …
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The Relapsing Fever Spirochete, Borrelia Hermsii, and Complement Regulatory Proteins
… America, binds the complement regulatory protein factor H (FH) as a means of evading opsonophagocytosis and the alternative pathway of complement. The sequence of the gene encoding the FH-binding protein has been determined. The protein is unique to B. hermsii and has been designated FhbA. …
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Studies of the pathogenesis of IgA nephropathy and Henoch-Schönlein purpura, with special reference to Streptococcus pyogenes infections and complement
… mutation heterozygous mutation in exon 2 of the factor H gene (CFH) in a child with IgAN complicated by thrombotic microangiopathy (TMA) most probably triggered by malignant hypertension. In addition, three heterozygous CFH polymorphisms were identified, known to increase the risk for TMA. This …
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Complement evasion strategies of human pathogens - the evolutionary arms race
… complement inhibitor found in human serum, factor I, and its two major cofactors C4b-binding protein (C4BP) and Factor H. This mechanism contributes to complement resistance of this bacterium. We also found that major periopathogens have the ability to bind to the membrane-bound complement …
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The role of complement FH and apoE interactions in the regulation of Aβ1-42 and C1q-mediated complement activation
… E (apoE) has been identified as a predisposing factor for late-onset Alzheimer’s disease (AD). ApoE is known to interact with one of the classically characterized hallmarks of AD, the amyloid-beta (Aβ) protein. Aβ activates the classical complement pathway by binding to C1q that may sustain …
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The Development and Implementation of a TMT-SRM Assay for the Validation of Candidate Biomarkers of Alzheimer’s Disease
… serum amyloid p-component and complement factor H. These proteins were previously found to be differentially expressed between plasma of Alzheimer’s disease subjects and non-demented controls. Additionally, apolipoprotein E4 was included in the panel as possession of the apolipoprotein e4 …
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Screen design for Borrelia burgdorferi lipoprotein secretion pathway components using periplasmic protein capture and suppressor mutations
… subsurface mutant of CspA. CspA is a complement factor H binding protein that renders the bacteria serum-resistant. The resulting subsurface mutant would provide a basis for a functional suppressor screen, selecting for pathway mutants that are capable of transporting the mutant CspA to the …
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Design and performance testing of a novel ceiling panel for simultaneous heat and moisture transfer to moderate indoor temperature and relative humidity
… the occupants inside the building. Although many factors can affect comfort, the factor of particular interest in this research is the indoor humidity level. High indoor humidity levels can make the indoor air feel stuffy at warm temperatures and reduce the amount of moisture that can be removed …
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Large eddy simulation of shock boundary layer interaction control using micro-vortex generators
… health as measured by the incompressible shape factor, H. Regions directly behind the ramp centerline tended to have increased boundary layer thickness indicating the significant three-dimensionality of the flow field. Compared to baseline sizes, smaller micro-ramps yielded improved total …
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Parapsychological investigation of the theory of Psychopraxia: experimental and theoretical researches into an alternative theory explaining normal and paranormal phenomena
… situations: (1) High scoring on four personality factors as measured on Cattell's 16PF: Factor F (Liveliness), Factor H (Social Boldness), Factor EX (Extraversion), Factor IN (Independence); (2) Low scoring on Factor Q4 (Tension); (3) Extreme scores on the Transliminality Scale (a measure of the …