Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"extrinsic regulators"”.
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Understanding the role of extrinsic regulators in normal and malignant haematopoiesis
… studies have highlighted the central role that extrinsic regulators play in both normal and malignant haematopoiesis. Recent evidence suggests that variations in key molecules can directly modulate haematopoietic stem cell (HSC) fate, implicating noncell intrinsic mechanisms for both maintaining …
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Co-optation of B Cell Developmental States in Malignancy and Autoimmunity
… is regulated through both cell-intrinsic and -extrinsic mechanisms, and can diversify through tightly regulated transitions. However, perturbations to these regulatory mechanisms facilitate shifts in cell phenotypes and function that, gone unchecked, can disrupt homeostasis and drive disease. …
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Epigenetic Regulation Controls Intrinsic and Extrinsic Drivers of Gastrointestinal Development
… I investigated how epigenetic forces control extrinsic regulators of lineage fate decisions, specifically intercellular communication. Here, I show that mesenchymal cells control epithelial fate and function through Polycomb Repressive Complex 2 (PRC2)-mediated chromatin bivalency. While key …