Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"extravasation"”.
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Intravenous Extravasation Management
… awareness in the topic of reducing intravenous extravasations. An assessment of my microsystem was completed that helped me identified the unit’s need for IV management safety. The problem assessed showed that approximately fifteen percent of intravenous catheters were infiltrated by the time …
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Tumor cell extravasation in an in vitro microvascular network platform
… understanding of the mechanisms of tumor cell extravasation is essential in creating therapies that target this crucial step in cancer metastasis. Extravasation assays exist, but with limitations; data from in vivo models are frequently inferred from low-resolution end-point assays while most …
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In vitro study of cancer cell extravasation in microfluidic platform
… into to a secondary site through a process of extravasation. Microfluidic systems have a major advantage in studying cancer extravasation since they can mimic aspects of the 3D in vivo situation in a controlled environment while simultaneously providing in situ imaging capabilities for …
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Discovery of Novel Mechanisms Regulating Cancer Extravasation in the Chorioallantoic Membrane Model
… then survive and leave by a process known as extravasation. Finally, extravasated cells proliferate and establish the secondary site in the metastatic cascade. Although extravasation encompasses key events during cancer cell invasion to aid in the development of effective treatments, an in …
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Blood-brain barrier model on a microfluidic chip for the study of tumor cell extravasation
… Understanding the mechanisms of tumor cell extravasation at the brain is therefore crucial to the development of therapeutic agents targeting this step in cancer metastasis, and to the overall improvement of cancer survival rates . Investigating the interactions between tumor cells and brain …
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A microvessel-on-a-chip for studying how tumor-derived factors prime the endothelium for extravasation
… tissue of distant organs. This process, called extravasation, is critical. If extravasation does not occur, distant metastases cannot form and 5-year survival increases from 25% to 56%. Better understanding extravasation is therefore key to stopping distant metastasis and reducing the mortality …
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Anatomically aware machine learning modeling of PET count rates for detection and quantification of radiotracer extravasation
Υπόβαθρο: Η Τομογραφία Εκπομπής Ποζιτρονίων σε συνδυασμό με την Αξονι κή Τομογραφία (PET/CT) χρησιμοποιείται ευρέως για την εκτίμηση της έκτασης των νοσημάτων και της μεταβολικής δραστηριότητας. Ενώ η αξονική τομογραφία παρέχει ανατομική πληροφορία, η PET επιτρέπει την ποσοτική αξιολόγηση …
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Engineered microvasculature platforms to study tumor-host-matrix interactions during metastatic seeding
… via the circulation. In particular, tumor cell extravasation is thought to be an essential and potential rate-limiting step, as most metastases are found in the extravascular space rather than intraluminal at distant organs. However, mechanistic insights into the cellular and molecular players …
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Corneal Wound Healing: Cells and Molecules
… response involving neutrophil (PMN) and platelet extravasation from the limbus. While these cells deliver important growth factors that promote wound healing, resolution of the inflammatory response (i.e., PMN clearance) is also needed to restore corneal homeostasis. This dissertation evaluated …
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Evaluation of a relatively hyperosmolar irrigation solution for use in equine femorotibial arthroscopy
… solutions have been shown to decrease fluid extravasation during arthroscopic procedures and safety has been demonstrated in canine and human studies. Prospective, blinded, randomized controlled trial was performed to compare lactated Ringer's solution (273 mOsm/L) and a hyperosmolar (600 …
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The Effect of Early Dietary Intervention on Alzheimer's Disease-Related Pathology and Cognitive Function in Mice
… (Aβ) deposition, decreased fibrinogen extravasation from blood vessels into the brain parenchyma, and improved cognitive function. RNAseq analysis revealed that HFD affected the expression of genes in the AD mouse cortex related to the stress response, protein folding, endoplasmic …
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Circadian Flux of Extravascular Polymorphonuclear Leukocytes in the Mouse Limbus
… determine if there is a circadian flux of PMN extravasation at the limbus in the uninjured cornea, and Aim 2 will determine if consumption of a HFD affects PMN extravasation at the limbus. Methods: C57BL/6 male mice (7 weeks of age; n=65 total) were fed a normal diet (ND) or a HFD. Some mice …
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Intracellular and extracellular promoters of metastasis to different organs
… IQGAP1 knockout significantly decreased extravasation of tumor cells from circulation.
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Inhibition of Margination and Diapedesis of Neutrophils by Protein Synthesis Blockade
… study tailored to its prevention. Neutrophil extravasation within the tissues during inflammation is the hallmark of this syndrome. Our study sought to block excessive neutrophil infiltration by inhibiting the biosynthesis of some essential proteins necessary for the process. In this initial …
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Effekte von Diaspirin cross-linked Hemoglobin (DCLHbTM) auf die Mikrozirkulation und den Gewebe–pO2 im Vergleich zu unterschiedlich lang gelagerten Erythrozytenkonzentraten im validierten Rückenhautkammermodel am Syrischen Goldhamster
… Kapillardichte, Leukozyten/Endothel-Interaktion, Extravasation, Scherrate. Zur Beurteilung der Makrohämodynamik wurden kontinuierlich der mittlere arterielle Blutdruck und die Herzfrequenz aufgezeichnet. Zur Beurteilung der lokalen Gewebe-Sauerstoffversorgung wurden für jede der 4 untersuchten …
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The third inguinal ring
… to the pubic tubercle and not medial to it, (9) Extravasation of urine is shown to extend largely as an infiltration of the superficial fasciae rather than as an extravasation deep to them, (104 Femoral hernia may emerge above or below the attachment of .Scarpa's fascia in the groin. The size of …
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Perception and Performance on the Prevention Management of Peripheral Intravenous Therapy Complications
… catheter embolism, hematoma, infiltration, extravasation, septicemia and venous spasm were rated 3.46, 3.39, 3.29, 3.28, 3.28, 3.27, 3.20, 3.16, 3.13, 3.09, 2.66 respectively. 3) After investigating the performance level of the prevention management of PITC, it has been found that air …
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Targeting Thromboxane A2 Receptor Signaling in Breast Cancer Metastasis
… reduces tumor cell motility, reduce tumor cell extravasation from the circulatory system, and most importantly, reduce breast cancer metastasis in vivo. These data provide compelling evidence suggesting that the TxA2-TP pathway plays an important role in breast cancer metastasis.
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Head Trauma Release of Histamine from Dural Mast Cells Alters Blood-Brain Barrier: Attenuation with Zolantidine
… before the trauma blocked 65% of the Evan's blue extravasation compared with the control and 2.5 mg group.
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Engineering M13 bacteriophage platforms for cancer therapy applications
… optimizing for phage blood circulation and tumor extravasation. Secondly, we have added to our cancer targeting M13 platform collection by cloning for chlorotoxin display on the tail p3 capsid protein of M13. Chlorotoxin can induce passage across blood-brain barrier, targets for cancer cells, and …
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