Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"extraocular muscle"”.
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The Effects of Self-Regulated Extraocular Muscle Tension on Intraocular Pressure.
… study was to examine the relationship between extraocular muscle tension and fluctuations in intraocular pressure (IOP) in normal subjects. Twenty subjects were asked to increase and decrease their EMG activity from the orbicularis muscle around the eye according to a biofeedback paradigm. …
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Duchenne muscular dystrophy and extraocular muscle: a potential sparing mechanism with therapeutic implications.
This project investigates the role of extraocular muscle (EOM) progenitor cells in sparing the muscles from pathology associated with Duchenne Muscular Dystrophy (DMD). Mouse models of muscular dystrophy and wild type mice were analyzed by flow cytometry and cell culture for the size, heterogeneity …
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Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis
… develop immunosuppressive therapyresistant extraocular muscle (EOM) dysfunction. We hypothesized that these patients have deficient DAF expression in their EOMs resulting in less protection from complement injury.
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Treatment-resistant ophthalmoplegia in Myasthenia gravis: extraocular muscle pathology, the role of TGFβ1 and the derivation of induced pluripotency towards 'disease-in-a-dish' modeling
… of patients has antibodies directed against muscle-specific tyrosine kinase (MuSK). In MG the pathogenic antibodies result in failure of neuromuscular transmission with consequent fatiguable skeletal muscle weakness. MG frequently affects the extraocular muscles (EOMs) early in the course of …
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Development of the ocular motor system in mouse embryos
… obtain precise visual feedback. In humans, six extraocular muscles form an oppositional pulley system to mediate slow, smooth tracking events as well as fast saccades. Their movement is dependent on three cranial nerves: the oculomotor, trochlear, and abducens. This study focuses on the …
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Force-extension of the Amylose Polysaccharide
… develop immunosuppressive therapy-resistant extraocular muscle (EOM) dysfunction. We hypothesized that these patients have deficient DAF expression in their EOMs resulting in less protection from complement injury. Sequence analysis of relevant regions of the DAF gene revealed a single …
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Identification and characterisation of novel marker proteins involved in X-linked muscular dystrophy
… cause fibre degeneration leading to severe muscle weakness. Skeletal muscle deteriorates to the extent that sufferers are wheelchair bound by early adulthood and severe diaphragm degeneration can lead to respiratory failure. Therapy in this area has lengthened life-span but at a more …
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Growth factors in extraocular muscles: effects on contractile properties
Extraocular muscles are a unique group of skeletal muscles, with distinct biological properties, including specialized myofiber types, a unique transverse and longitudinal organization of myofibers, continued muscle plasticity and the retention of activated progenitor cells in adult normal muscles. …
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Treatment-resistant ophthalmoplegia in myasthenia gravis: Clinical, molecular and functional studies of patient-derived orbital tissues
… the neuromuscular junction. Weakness of the extraocular muscles (EOMs) occurs frequently in MG and typically responds to immune therapies similarly to the non-ocular muscles. Susceptible individuals with the ophthalmoplegic subphenotype of MG (OP-MG), which occurs almost exclusively in …
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Investigating the functionality of candidate susceptibility genes in ophthalmoplegic myasthenia gravis using patient-derived material
… described by our group is characterised by extraocular muscle (EOM) weakness which does not respond to standard immunosuppressive therapy whilst the non-ocular muscles do respond to treatment. OP-MG predominantly affects patients of African genetic ancestry and most commonly those with …
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Identifying the molecular basis for treatment resistance in a subset of myasthenia gravis patients of African ancestory
… or destroy the acetylcholine receptors of the muscle endplate resulting in failure of neuromuscular transmission and fatigable weakness. We have previously shown that a subpopulation of South African MG patients of African genetic ancestry develop a severe extraocular muscle (EOM) phenotype …