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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 37 for “"extracellular-signal regulated kinase (ERK)"”.

  1. Role of Extracellular Signal-Regulated Kinase (ERK) in Regulation of Intestinal Epithelial Tight Junctions

    Aggarwal, Sudhir2016

    <p>Evidence indicates that MAP kinase (ERK1/2) is involved in regulation of epithelial tight junctions. There are different opinions expressed by investigators as to whether ERK disrupts the junctions or protects them. ERK has also been demonstrated to mediate the EGF-caused protection of the …

    tenn-hsc Repository record

  2. Activation of the Transient Receptor Potential Vanilloid-1 (TRPV1) channel mediates Extracellular Signal Regulated Kinase (ERK) phosphorylation via Beta-arrestin-2 signaling

    Aboushousha, ReemGraduate Studies2015

    … Interestingly, β-arrestin-2 also acts as a signaling scaffold for the MAPK (ERK1/2) pathway which was described as an important nociceptive marker. In this thesis, several experimental approaches were employed to investigate TRPV1 signaling and to characterize whether β-arrestin-2 as well as …

    calgary Repository record

  3. Observing the effects of acetylcholinesterase and brain-derived neurotrophic factor on the levels of soluble amyloid precusor protein α in lung cancer cell media

    Coleman, Kai-ling Elle2023

    … we hypothesize that the levels of sAPPα are regulated by AChE and mBDNF. When cells were treated with AChE, sAPPα levels were decreased while Aβ levels increased which suggests that AChE might play a role in shifting APP processing towards the amyloidogenic pathway and away from the …

    emich Repository record

  4. Quantitative analysis of TLR-4-mediated cell responses in murine macrophages

    Wu, RongcongMassachusetts Institute of Technology2008

    … can in tandem initiate a pair of downstream signaling pathways to regulate cytokine/chemokine release, endotoxin tolerance and apoptosis, which have been suggested to directly or indirectly participate in the regulation of innate and adaptive immune responses. However, little is known about …

    mit Repository record

  5. Intracellular Signaling Contributions to Behaviors Relevant to Nicotine Addiction

    Thompson, Lauren2016

    … daily exposure/after 8+ days of abstinence is regulated by extracellular signal-regulated kinase (ERK) signaling in the nucleus accumbens (NAc) shell or anterior cingulate cortex (PFC). ERK kinase inhibitor U0126 was infused in the NAc shell or PFC of Long Evans rats immediately prior to daily …

    vcu Repository record

  6. Analysis of ASCL1 in Neuroendocrine Lung Cancer

    He, Min2017

    … regulate the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway through a negative feedback mechanism. Finally, we found that expression of ASCL1 in certain NSCLC could induce neuroendocrine features which are reminiscent of SCLC.

    utswmed Repository record

  7. Dysregulated ERK signal pathway and immune profiles in Fragile X Syndrome

    Weng, NingUniversity of Illinois at Urbana-Champaign2012

    … observed delayed early-phase phosphorylation of extracellular-signal regulated kinase (ERK), a nodal point for cell signaling cascades, in both neurons and thymocytes of fmr-1 KO mice. We further reported that early-phase kinetics of ERK activation in lymphocytes from human peripheral blood is …

    uiuc Repository record

  8. Assessing eIF4E-S209 Signaling and Translationally Regulated Mechanisms in Neurodegeneration

    Tuccitto, Maria Alessandra2023

    … models have implicated mitogen activated protein kinase (MAPK) signaling cascades. The MAPKs extracellular signal-regulated kinase (ERK) and p38 can play an important role in translational control through the mRNA cap binding protein, eukaryotic translation initiation factor 4E (eIF4E). Downstream …

    toronto-retro Repository record

  9. The Potential of CRL4-DCAF1 and KSR1 as Therapeutic Targets in Low-grade Merlin-Deficient Tumours

    Lyons Rimmer, Jade2018

    … protein that is frequently mutated or downregulated in cancer. Biallelic Merlin inactivation is causative of tumour formation, including schwannoma, meningioma and ependymoma. These tumours can occur sporadically or as part of the genetic condition Neurofibromatosis type 2 (NF2) and cause …

    plymouth Repository record

  10. The Effects of PPAR-γ Activators on the Growth and Apoptosis of Melanocytes

    이, 중선2011

    … apoptosis. I further examined the regulation of extracellular signal regulated kinase (ERK) pathway under ciglitazone treatment. METHODS: The growth of melanocytes was measured using the Coulter counter and the effects on pigmentation were investigated with measurement of melanin contents of …

    ajou Repository record

  11. Learning to be a cocaine addict: behavioral, pharmacological, and molecular characterization of individual differences in initial learning of cocaine-environment associations

    Adriane M dela CruzThe University of Texas Medical Branch2009

    … glutamate receptor subunit 1 (GluR1), and a signaling system associated with these receptors (i.e., the mitogen-activated protein kinase extracellular-signal regulated kinase; ERK) in the cortical-limbic regions--may modulate the acquisition and expression of cocaine-environment associations. …

    utmb Repository record

  12. Characterization and Reversal of Doxorubicin-Mediated Changes In Sensory Neurons

    Coughlin, Brittany L, <p>orcid.org/0000-0002-0796-1512</p>2018

    … In addition, DOX leads to dynamic activation of extracellular signal-regulated kinase (ERK), consisting of an immediate and a delayed phase of activation, and to transient activation of p38 mitogen-activated protein kinase (p38 MAPK) in <em>Aplysia</em> sensory neurons. These two MAPKs have …

    uthsc Repository record

  13. The Immunomodulatory Functions Of Diacylglycerol Kinase Zeta On Type 2 Immune Responses

    Singh, Brenal2019

    … of allergy and asthma. Weak TCR-mediated extracellular signal-regulated kinase (ERK) signals are thought to promote Th2 differentiation in vitro. However, it was unclear whether selective enhancement of specific TCR-mediated signal transduction pathways could suppress Th2 differentiation …

    penn Repository record

  14. Investigation on the Intracellular Sognal Transduction Mechanism of Human Dermal Fibroblasts of Photorejuvenation in Photodynamic Therapy

    장, 용현2011

    … was to investigate the effects of PDT on the signal transduction mechanism in human dermal fibroblast and the role of reactive oxygen species (ROS) in vitro. Normal human fibroblasts were treated with various sublethal and relatively low doses of 5-aminolevulinic acid (ALA) and red light. The …

    ajou Repository record

  15. Investigation of Cellular Responses Activated by Mechanical Compression in Equine Chondrocytes: Device Design, Construction and Testing

    Cassino, Theresa R.Virginia Tech2006

    … activity of cartilage cells (chondrocytes) is regulated by mechanical forces which act on them. Chondrocytes can respond to these forces through synthesis or degradation of extracellular matrix and changes in gene expression. The overall objective of this study was to investigate the effects of …

    vt Repository record

  16. Untersuchungen zu intrazellulären Folgereaktionen von Neisseria meningitidis und Escherichia coli K1 in HBMEC (human brain microvascular endothelial cells)

    Nikulin, JoannaUniversität Würzburg

    … den initialen Kontakt des Erregers ausgelösten Signalkaskaden. Die Rolle des für eine ADP-Ribosyltransferase kodierenden narE Gens in der Pathogenese der Meningokokken-Infektion und die mögliche Bedeutung in der Aktivierung von Signaltransduktionsmechanismen wird diskutiert. Eine narE …

    wurz-thes Repository record

  17. RAF-1 kinase inhibitor protein-mediated cholecystokinin-2 receptor desensitization and extracellular signal-regulated kinase activation

    Jeseong ParkThe University of Texas Medical Branch2009

    Raf-1 kinase inhibitor protein (RKIP) is initially known as a suppressor for Raf-1-mediated ERK activation. Moreover, recent findings indicate that RKIP also has a role in G-protein-coupled receptor (GPCR) desensitization. Protein kinase C (PKC)-mediated phosphorylation at Serine 153 (S153) on RKIP …

    utmb Repository record

  18. The direct effects of estradiol and several xenoestrogens on cell numbers of early- vs. late-stage prostate cancer cells

    Koong, Luke YThe University of Texas Medical Branch at Galveston2016

    … we identified cellular pathways and rapid signaling events that act via estrogen receptors (ERs) and contribute to estradiol (E2) or DES-mediated cell killing/growth arrest. E2 was much more effective than DES at reducing cell numbers of both LAPC-4 early-stage androgen-dependent and PC-3 …

    utmb Repository record

  19. ROLE OF THE Na,K-ATPase IN POLYCYSTIC KIDNEY DISEASE

    Nguyen, Anh-Nguyet ThiUniversity of Kansas2008

    … The transport properties of the Na,K-ATPase is regulated by the hormone ouabain, which inhibits its movement of the cations. In addition, ouabain binding to the Na,K-ATPase has been been found to activate a cascade of phosphorylating events, leading to cell growth. Interestingly, we have found a …

    ku Repository record

  20. Isoform-Specific Roles of Extracellular Signal-Regulated Kinases in Pain

    Alter, Benedict2013

    … OF THE DISSERTATION Isoform-specific roles of Extracellular Signal-Regulated Kinases in pain by Benedict Joseph Alter Doctor of Philosophy in Biology and Biomedical Sciences Neurosciences Washington University in St. Louis, 2012 Professor Robert Gereau, Chairperson The extracellular …

    wustl Repository record

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