Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"extracellular traps"”.
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Neutrophil extracellular traps in periodontitis
… thesis has investigated the role of neutrophil extracellular traps (NETs) in the pathogenesis of periodontitis. A fluorometric assay was developed for the in vitro quantification of NET release and used to assess relative levels in chronic periodontitis patients, indicating elevated release …
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The effect of human cytomegalovirus on neutrophil survival, autophagy, and extracellular traps
… from granules, and formation of neutrophil extracellular traps (NETs). Despite this, certain pathogens have evolved mechanisms to benefit from neutrophil effector functions. Human cytomegalovirus (HCMV) is a clinically important pathogen that infects the majority of the human population. …
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Induction of Neutrophil Extracellular Traps by Nontypeable Haemophilus Influenzae And Defense Mechanisms Against Host NETs and Oxidative Stress
Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative commensal bacteria of the human nasopharynx. Normally residing in healthy individuals, NTHi rarely causes adverse effects. However, infection with NTHi in children often leads to middle ear inflammation and disease in the form of otitis …
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Synthesis, Radiolabeling and Evaluation of a suite of Tracers with <sup>44</sup>Sc for Detecting Extracellular DNA
<p>Neutrophil extracellular traps involve the rapid translocation of DNA to the outside of the cell under certain stimuli. This structure forms a fibrous network that is able to limit the spread of pathogens and to kill microorganisms. It has also been shown to be present in various pathological …
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Host-Defense Function of Anuclear Polymorphonuclear Neutrophil in Lung Injury
… to form web-like structures called Neutrophil Extracellular Traps (NETs). After NET release (NETosis), the PMN generates anuclear cells (PMNcyto). We found that 50% of PMN in lung microvessels had transitioned to PMN cytoplasts (PMNcyto) within 24h exposure to endotoxemia. Despite being …
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Human neutrophils generate extracellular vesicles that modulate their functional responses
… and chemokines, by generating neutrophil extracellular traps (NETs), and by modulating their own survival. Neutrophils also produce extracellular vesicles (EVs) termed ectosomes, which influence the function of other immune cells. Here, we studied neutrophil-derived ectosomes (NDEs) and …
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The role of megakaryocytes and platelets in infection and immunothrombosis
… functions, including: phagocytosis, formation of extracellular traps, and chemotaxis towards pathogenic stimuli. MKs were also observed to directionally release platelets towards pathogenic stimuli. In addition to their primary role as immune cells, MKs were also shown to contain extranuclear …
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Early and late events in NET formation
… are known to produce NETs (for neutrophil extracellular traps) – networks of extruded decondensed chromatin adorned with antimicrobial molecules, which primarily serve to immobilize and inactivate pathogens (bacteria, viruses, yeasts, and fungi). In addition, it has been widely reported …
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Characterization of the Staphylococcus aureus Immunodominant Surface Antigen B, IsaB
… pH induce expression. We found that IsaB is an extracellular nucleic acid binding protein, able to bind to dsDNA, ssDNA, and RNA and leads significant accumulation of eDNA on the cell surface. We employed multiple virulence models to ascertain the role of IsaB in virulence. Excitingly, we found …
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Hypoxia induces selective neutrophil degranulation to promote endothelial damage in COPD
… reactive oxygen species and release neutrophil extracellular traps (NETs). However, these anti-microbial strategies can also cause substantial bystander tissue injury. Infected and inflamed tissues are profoundly hypoxic, and this oxygen depletion both compromises neutrophil-mediated bacterial …
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Mild traumatic brain injury augments innate immune responses through neurokinin and cholinergic signaling
… from mTBI mice produced more neutrophil extracellular traps in response to bacterial challenge. These studies show that neurokinin signaling in our model contributes to enhanced bacterial clearance. Cholinergic anti-inflammatory pathway signaling though the α7 nicotinic acetylcholine …
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Development of 3D multicellular liver organoids derived from human induced pluripotent stem cells to model antiretroviral therapy induced liver injury
… oxidative stress, protein synthesis, neutrophil extracellular traps (NETs) formation, the ATP-dependent chromatin remodelling and necroptosis. Conclusion: We successfully generated multicellular 3D liver organoids consisting of hepatocytes, Kupffer cells and hepatic stellate cells. Proteomic data …
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Characterizing The Source of Neutrophil Elastase and Proteinase 3 Cross-Presentation In B-Cell Acute Lymphoblastic Leukemia
… NE and P3 in the microenvironment is neutrophil extracellular traps (NETs). NETs are composed of deoxyribonucleic acid (DNA)/histones extruded from polymorphonuclear neutrophils (PMNs) abundant in antimicrobial proteases, including NE and P3. Although a main function of NETs is elimination of …
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Autoimmune Consequences of Histone Deimination during Neutrophil Activation
… modification of histones and results in the extracellular release of chromatin. The extracellular chromatin incorporates histones in which arginines have been converted to citrullines by peptidylarginine deiminase IV (PAD4) creating structures that capture or "trap" bacterial pathogens. …
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Novel innate immune functions of saliva
… decorated with AMPs known as neutrophil extracellular traps (NETs). These saliva-induced NETs had great capacity for entrapment and killing of bacteria. Lastly, we explored the effect of saliva on plasma, in presence of pathogenic streptococci. Streptococcal pharyngitis is defined by …
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Immune Recognition of Self Nucleic Acids Driven By Endogenous Antimicrobial Peptides: Role In Autoimmunity
Innate immune recognition of extracellular host-derived self-DNA and self-RNA is prevented by endosomal seclusion of the Toll-like receptors (TLRs) in the dendritic cells (DCs). However, in psoriasis plasmacytoid dendritic cells have been found to be able to sense self-DNA molecules in complex with …
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Unraveling Epigenetic Mechanisms That Regulate Breast Cancer Lung Metastatic Relapse by Rewiring the Immune Microenvironment
… depleting antibody, Sivelestat (Neutrophil Extracellular Traps inhibitor) and anti-LAG3+anti-CTLA4 immunotherapy regime abrogated the Brd7-KO induced lung metastasis.</p> <p>Taken together, our findings that BRD7 is a suppressor of breast cancer lung metastasis and a predictive cancer …
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Investigating the immunosuppressive functions of the GPCR adapter protein Norbin
… degranulate more and produce more neutrophils extracellular traps (NETs) than control neutrophils, and their elevated killing of *S. aureus* is dependent on NETs, whereas their production of inflammatory cytokines is normal. I showed that Norbin controls the Rac-GEFs Vav, which is …
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Characterizing Inflammatory Mechanisms in Hidradenitis Suppurativa
… cells and neutrophils, formation of neutrophil extracellular traps, and increased production of epithelium-derived inflammatory cytokines. Our work demonstrates that dermal tunnels are active contributors to the inflammatory burden of HS. To address whether tunnels are associated with a unique …
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