Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"extracellular signal-regulated protein kinase"”.
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues that are …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues that are …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues that are …
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PPARγ-pERK interaction restores memory consolidation in an Alzheimer’s disease model
… the Tg2576 mouse model for AD amyloidosis. Since extracellular signal-regulated protein kinase mitogen-activated protein kinase (ERK MAPK) is required for many forms of learning and memory that are affected in AD, and since both PPARγ and ERK are key mediators of insulin signaling, we tested the …
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Characterization of Agrin Function in Chicken and Zebrafish Embryogenesis.
Agrin is an extracellular matrix heparan sulfate proteoglycan that plays a key role in the development of the neuromuscular junction (NMJ) by inducing the clustering of acetylcholine receptors at synaptic sites of the NMJ. Although recent studies have extended our understanding of agrin's function …
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Chlorpyrifos and chlorpyrifos oxon induce neurite retraction and cytoskeletal disruption in mouse N2a cells and human neural progenitor stem cells
… toxicity to the regulation of cytoskeletal proteins involved in neural differentiation. At 3 μM, both compounds reduced the numbers of axon-like processes in pre-differentiated N2a cells, as indicated by morphometric analysis of carboxyfluorescein succinimidyl ester-labelled cells. …
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Nuclear Behaviors of ERK1/2 Signaling
… fibrosarcoma (Raf)- mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK) kinase (MEK)- ERK pathway is essential for proper development and homeostatic regulation in eukaryotic cells. Many pathway functions are carried out by ERK1 and ERK2 (ERK1/2), …
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The effect of exercise on spatial learning and hippocampal proteins in maternally separated adult rats
… increases in levels of synaptophysin and phospho-extracellular signal-regulated protein kinase (pERK) in the hippocampus of non-separated-exercised rats. In the current study, the same MS technique and three-week voluntary exercise regimen were tested to determine their effect on spatial learning …
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Induction of Anopheles stephensi nitric oxide synthase by Plasmodium-derived factor(s)
… factors that can induce AsNOS expression and the signaling pathways responsible for transduction in A. stephensi have not been identified until completion of the work described herein. In my studies, I have determined that P. falciparum glycosylphosphatidylinositol (PfGPIs) can induce AsNOS …
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Role of Redox-Active Trace Metal (RATM) Oxidants in the Regulation of Toll-Like Receptor 4 (TLR4) Signaling-Mediated Inflammatory Phenotype in Synovial Fibroblasts
… cytometry (FC), respectively. Activation of TLR4 signaling pathway was determined by measuring the expression of TLR4 and the downstream signaling proteins. Either ELISA kits or FC quantified levels of TNF-α, interleukin (IL-1β), and HMGB1 (as pro-inflammatory agents), and IL-10 (as an …
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Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in
… of senescent cells is the failure of phospho-extracellular signal-regulated protein kinase 1/2 (pErk1/2) translocation to nuclei in response to growth factor stimulation. However, when senescent cells are treated with 12-O-tetradecanoylphorbol-13-acetate (TPA), old cell morphology starts to …
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The Effects of PPAR-γ Activators on the Growth and Apoptosis of Melanocytes
… apoptosis. I further examined the regulation of extracellular signal regulated kinase (ERK) pathway under ciglitazone treatment. METHODS: The growth of melanocytes was measured using the Coulter counter and the effects on pigmentation were investigated with measurement of melanin contents of …