Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 71 for “"extracellular signal regulated kinase"”.
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Role of Extracellular Signal-Regulated Kinase (ERK) in Regulation of Intestinal Epithelial Tight Junctions
<p>Evidence indicates that MAP kinase (ERK1/2) is involved in regulation of epithelial tight junctions. There are different opinions expressed by investigators as to whether ERK disrupts the junctions or protects them. ERK has also been demonstrated to mediate the EGF-caused protection of the …
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Analysis of the role of extracellular signal regulated kinase (ERK5) in the differentiation of muscle cells
The MEK5/ ERK5 kinase module is a relatively new discovered mitogen-activated protein kinase (MAPK) signalling pathway with a poorly defined physiological function. Since ERK5 and its upstream activator MEK5 are abundant in skeletal muscle a function of the cascade during muscle differentiation was …
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RAF-1 kinase inhibitor protein-mediated cholecystokinin-2 receptor desensitization and extracellular signal-regulated kinase activation
Raf-1 kinase inhibitor protein (RKIP) is initially known as a suppressor for Raf-1-mediated ERK activation. Moreover, recent findings indicate that RKIP also has a role in G-protein-coupled receptor (GPCR) desensitization. Protein kinase C (PKC)-mediated phosphorylation at Serine 153 (S153) on RKIP …
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Biological and biochemical characterization of the extracellular signal-regulated kinase 8 homolog (TbERK8) in Trypanosoma brucei
… small molecules. The mitogen-activated protein kinases (MAPK) pathway is a three-tiered signaling cascade that regulates cell responses to stimuli and are involved in essential processes. MAPKs can regulate differentiation, virulence, apoptosis, cell cycle and gene expression, which makes MAPKs …
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Functional Roles of A1-adrenergic Receptors in the Bovine Inferior Alveolar Artery: Regulation of Contraction and Activation of Extracellular Signal Regulated Kinase
The bovine inferior alveoiar artery (BIAA) runs inside the length of the mandibie and branches to form dental arteries that supply blood to the teeth. I investigated the effects of 5-hydroxytryptamine (5-HT), acetylcholine (ACH), calcitonin gene-related peptide (CGRP) and norepinephrine (NE) on …
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Activation of the Transient Receptor Potential Vanilloid-1 (TRPV1) channel mediates Extracellular Signal Regulated Kinase (ERK) phosphorylation via Beta-arrestin-2 signaling
… Interestingly, β-arrestin-2 also acts as a signaling scaffold for the MAPK (ERK1/2) pathway which was described as an important nociceptive marker. In this thesis, several experimental approaches were employed to investigate TRPV1 signaling and to characterize whether β-arrestin-2 as well as …
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Extracellular Signal-Regulated Kinase 7, A Fast Evolving Map Kinase Under Positive Selection, Is Associated With Multiple Levels Of Honeybee Behavioral Plasticity
Submitted by Jason Ebaugh (ebaugh@illinois.edu) on 2009-07-04T21:26:59Z No. of bitstreams: 1 EbaughJasonDissertation.pdf: 9370507 bytes, checksum: 6fc1987ff7690d3a540912672da149c0 (MD5)
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The Effects of PPAR-γ Activators on the Growth and Apoptosis of Melanocytes
… apoptosis. I further examined the regulation of extracellular signal regulated kinase (ERK) pathway under ciglitazone treatment. METHODS: The growth of melanocytes was measured using the Coulter counter and the effects on pigmentation were investigated with measurement of melanin contents of …
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Design, Synthesis and Evaluation of Diphenylamines as MEK5 Inhibitors
The mitogen-activated protein kinases (MAPK) are a family of interrelated signal transduction kinases mediating intracellular responses to extracellular events. They are involved in mediating complex cellular events including, cell differentiation, cell proliferation, and cell death. Extracellular …
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DUSP5 Regulation of Inflammation and Insulin Signaling
… tumor necrosis factor ? (TNF?). TNF? stimulates signaling of mitogen-activated protein kinases (MAPKs) within adipocytes (i.e. fat cells) and muscle cells that drive systemic inflammation and insulin resistance, leading to T2D. Until recently, most studies focused on the role of upstream kinases …
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Observing the effects of acetylcholinesterase and brain-derived neurotrophic factor on the levels of soluble amyloid precusor protein α in lung cancer cell media
… we hypothesize that the levels of sAPPα are regulated by AChE and mBDNF. When cells were treated with AChE, sAPPα levels were decreased while Aβ levels increased which suggests that AChE might play a role in shifting APP processing towards the amyloidogenic pathway and away from the …
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Regulatory role of phosphatidylinositol 4-phosphate 5-kinases in brain inflammation
… by the type I phosphatidylinositol 4-phosphate 5-kinase (PIP5KI) family members, PIP5KIα, PIP5KIβ and PIP5KIγ, is an important regulator of diverse cellular processes at the cell surface, such as cell survival, cell proliferation, phagocytosis, macropinocytosis membraned ruffles, ion channels …
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Quantitative analysis of TLR-4-mediated cell responses in murine macrophages
… can in tandem initiate a pair of downstream signaling pathways to regulate cytokine/chemokine release, endotoxin tolerance and apoptosis, which have been suggested to directly or indirectly participate in the regulation of innate and adaptive immune responses. However, little is known about …
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Novel mechanism of gastric proton pump inhibitor (PPI) : Suppression of Helicobacter-pylori induced angiogenesis and selective induction of apoptosis in gastric cancer cells.
… in an ischemic microenvironment with a lower extracellular pH, ability to up-regulate proton extrusion is critical for cancer cell survival. Gastric H+/K+-ATPase exchanges luminal K+ for cytoplasmic H+ and is the enzyme primarily responsible for gastric acidification. On the basis of the fact …
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Intracellular Signaling Contributions to Behaviors Relevant to Nicotine Addiction
… daily exposure/after 8+ days of abstinence is regulated by extracellular signal-regulated kinase (ERK) signaling in the nucleus accumbens (NAc) shell or anterior cingulate cortex (PFC). ERK kinase inhibitor U0126 was infused in the NAc shell or PFC of Long Evans rats immediately prior to daily …
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Isoflurane-induced post-conditioning in senescent hearts is attenuated by failure to activate reperfusion injury salvage kinase pathway
… the activation of the reperfusion injury salvage kinase (RISK) pathway to address a possible mechanism underlying age-related differences. METHODS AND RESULTS: Male Wistar rats were assigned to age groups (young, 3–5 months; old, 20–24 months), and randomly selected to receive isoflurane (1 …
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Analysis of ASCL1 in Neuroendocrine Lung Cancer
… regulate the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway through a negative feedback mechanism. Finally, we found that expression of ASCL1 in certain NSCLC could induce neuroendocrine features which are reminiscent of SCLC.
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With No Lysine (WNK) Family Proteins and Their Interaction with Downstream Kinases
With no lysine (WNK) kinases are a family of protein kinases characterized by unusual kinase domain architecture. These large proteins, divergent outside of a kinase core and protein-protein interaction motifs, have been associated with pseudohypoaldosteronism 2, a form of Mendelian-inherited …
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Two Sides of The Same Coin in The Levodopa Treatment of Parkinson's Disease
… role of NMDA receptor-mediated activation of the extracellular signal-regulated kinase-mitogen-activated protein (ERK-MAP) kinase pathway in Hcy - dependent neurotoxicity on NPCs in isolated from the postnatal subventricular zone (SVZ) and in PD animal model.
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Dysregulated ERK signal pathway and immune profiles in Fragile X Syndrome
… observed delayed early-phase phosphorylation of extracellular-signal regulated kinase (ERK), a nodal point for cell signaling cascades, in both neurons and thymocytes of fmr-1 KO mice. We further reported that early-phase kinetics of ERK activation in lymphocytes from human peripheral blood is …
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