Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"extracellular regulated kinase (ERK)"”.
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Einfluss von Angiotensin II und Endothelin-1 auf die Kontraktilität isolierter Kardiomyozyten aus gesundem und terminal insuffizientem Myokard
… H7 ist ein spezifischer Hemmstoff der Proteinkinase C (PKC). Es zeigte sich, dass die ET-1-Wirkung am Vorhof PKC-vermittelt ist, jedoch unabhängig von einer Aktivierung des NHE ist. Die Ang II-Wirkung an Vorhofzellen konnte ebenfalls durch eine Hemmung der PKC blockiert werden. An Zellen aus …
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Biomolecular effects and bioclinical applications of PARPs inhibitors
… also acts in a DNA independent way within the Extracellular-Regulated-Kinase (ERK) signaling cascade, which regulates cell proliferation and differentiation. By western analysis and confocal laser scanning microscopy (LSM), we analysed the effects of PJ-34 on PARP-1 expression, phospho-ERK and …
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Role of the PI-3K/Akt and ERK pathways in phencyclidine-induced neurotoxicity in neonatal rats and the protection by lithium and BDNF
… action of PCP on the phosphatidylinositol-3 kinase (PI-3K)/Akt and extracellular regulated kinase (ERK) pathways and suppressed activation of the pro-apoptotic factor, glycogen synthase kinase-3â (GSK-3â), evoked by PCP. Furthermore, blocking either the PI-3K/Akt or the ERK pathway …
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A Mechanistic Evaluation of how Melatonin Enhances Alkaline Phosphatase Activity in Human Adult Mesenchymal Stem Cells
… differentiation. The mitogen activated protein kinase signaling mechanisms has been implicated in osteoblast differentiation. Based on these findings, we hypothesized that melatonin acts through the mitogen activated protein kinase signaling cascade to enhance hAMSC differentiation into an …
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BETA 2 NICOTINIC ACETYLCHOLINE RECEPTOR CONTRIBUTIONS TO ANXIETY-LIKE BEHAVIOR
… exposure to stressors reduces phosphorylation of extracellular regulated kinase (ERK) in the lateral septum. In these studies, levels of pERK in the lateral septum were inversely associated with alpha4beta2*nAChR expression as well as anxiogenic-like behavior. In sum, these preclinical studies …
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The Role Of ROS-mediated ERK and JNK Activation In The Induction Of Autophagy And Apoptosis In Tumour Cells By A Novel Small Molecule Compound
… of autophagy and apoptosis via activation of extracellular regulated kinase (ERK) and c-Jun N-terminal kinase (JNK). Inhibition of ERK and JNK virtually completely blocked drug-induced autophagy and apoptosis. Interestingly, inhibition of JNK activity reversed C1-induced increase in Atg7 …
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The crosstalk between the ERK and the cAMP signalling pathways in PC12 Cells
The extracellular-regulated kinase (ERK) signalling pathway is involved in the control of different biological processes such as survival, proliferation and differentiation. In PC12 cells, the ERK signalling pathway integrates different external stimuli: epidermal growth factor (EGF) stimulates the …
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MECHANISMS OF NEUROPROTECTION IN SCN2.2 CELLS
… this endogenous neuroprotection in SCN2.2 cells. Extracellular regulated kinase (ERK) is expressed in the SCN, activated by Glu, and is anti-apoptotic in other systems. Therefore, this thesis was designed to test the following central hypothesis: SCN2.2 cells are dependent on ERK signaling for …