Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"extracellular recording"”.
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Effects of sound direction on spectral and temporal processing in the frog midbrain
… processing, were investigated by single-unit extracellular recording from the frog inferior colliculus (IC). The neural activities were evaluated from 3 to 5 sound directions within 180$\sp\circ$ of frontal field in the free-field stimulus system. The results from this study provide …
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Scalable Bundle Design for Massively Parallel Neuronal Recordings <i>In Vivo</i>
… networks to understand how the brain functions. Extracellular recording is the oldest method of measuring neural activity and can sample at a temporal resolution to resolve fast spiking neurons. If scaled to a sufficiently large number of simultaneous recorded neurons, this technique would be an …
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Ground truth in ultra-dense neural recording
… there have been very few multi-electrode recordings done in concert with techniques such as patch clamp, which report the "ground truth" voltage state of a single neuron in a population. Such recordings would allow for the direct evaluation of spike sorting, which in turn could lead to …
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Functional and Categorical Analysis of Waveshapes Recorded on Microelectrode Arrays
… to several weeks. The signature wave shapes from extracellular recording of neuronal activity display a great variety of shapes with triphasic signals predominating. I characterized extracellular recordings from over 600 neuronal signals. I have preformed a categorical study by dividing wave …
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Autonomous cricket biosensors for acoustic localization
… the cercal system appears to be most reactive. Extracellular recording electrodes are permanently implanted into a cricket's ventral nerve cord to record the action potentials emanating from the cerci. In order to calibrate this system, we attempt to find the relationships between the frequency …
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Temporal synchronization of CA1 pyramidal cells by high-frequency, depressing inhibition, in the presence of intracellular noise
… Wave-associated Ripple is a high-frequency, extracellular recording observed in the rat hippocampus during periods of immobility. During the ripple, pyramidal cells synchronize over a short period of time despite the fact that these cells have sparse recurrent connections. Additionally, the …
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Electrophysiological characterization of a mouse deficient for oligophrenin1: a mouse model of X-linked mental retardation
… the functioning of a neuronal population using extracellular recording of fast oscillations which are thought to underlie higher cognitive performance. I showed that \(Ophn-1\) null mice displayed weaker gamma oscillations. Thereafter, Investigation of the synaptic properties of CA3 pyramidal …
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Characterization of Thermosensitive Preoptic Neurons in the Green Sunfish, Lepomis Cyanellus
… acclimated to 25(DEGREES)C were obtained using extracellular recording techniques and classified into 5 basic types. Type 1 neurons, which comprised 4% of the total, had low firing rates (approximately 5/second) at 25(DEGREES)C brain temperature. Firing rate increased exponentially with …
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Microsystem Based on CMOS Multielectrode Array for Extracellular Neural Stimulation and Recording
… standard techniques for accurate stimulation and recording of electrical activities in neurons. Nevertheless, the number of electrodes that can be introduced into the working chamber is severely limited by the electrode dimension and head stages. Integrating electrodes on chip with complementary …
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Supraspinal actions of pentobarbital on transmission through the spinothalamic tract
… in the rat, was assessed using single neuron extracellular recording techniques before, during and after microinjections of PB into the MPTA. Spontaneous firing rate (SFR), antidromic firing index (FI) and sciatic as well as sural nerve-evoked responses (Sc-, Su-ER) of STT neurons in …
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Functional Identification of Nucleus Tractus Solitarius (NTS) Barosensitive Neurons: Effect of Chronic Intermittent Hypoxia (CIH)
… anaesthetized with Ket/Ace. Using single-unit extracellular recording technique, we recorded NTS barosensitive neurons in response to arterial pressure (AP) changes induced by descending aorta occlusion. Our data indicated that 1) the mean arterial pressure and HR were similar in RA control and …
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Inference of functional neural connectivity and convergence acceleration methods
… experimental methods which allow a simultaneous recording of the spiking activity, but not the intracellular voltage, of thousands of neurons gives us an opportunity to start filling that gap. In Chapter 2, I present a method for the inference of the parameters of the leaky integrate-and-fire …
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Effect of dopamine on synchronous neuronal oscillations in the globus pallidus-subthalamic nucleus network
… receptor antagonist CNQX (10 μM). Paired extracellular recordings of STN cells showed uncorrelated firing. Oscillatory burst activity was induced pharmacologically using the glutamate receptor agonist, NMDA (20 μM), in combination with the potassium channel blocker apamin (50 -100 nM). The …
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A P-glycoprotein-like mechanism in the nicotine-resistant insect, Manduca sexta.
… the non-feeding pupal and adult stages. Using an extracellular recording technique to monitor levels of neural activity in isolated abdominal nerve cords, I demonstrated that, in contrast with larval M. sexta, the CNS of both the pupal and adult stages are both highly nicotine-sensitive. …
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Analysis and Synthesis of the Dynamic Response of Retinal Neurons
… obtained from the in-situ retina by means of extracellular recording of impulse activity in single optic nerve fibers. Test ommatidia were chosen in the interior of the retina, to avoid asymmetries introduced by the edge of the retina. Stimuli which varied in both space and time were produced …
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Role of galanin in synaptic transmission and plasticity in the CA1 area of the rodent hippocampus
… were investigated using both intracellular and extracellular recording techniques in vitro. LTP induced in either apical or basal dendrites of CA1 pyramidal neurones by different paradigms was significantly inhibited by galanin. Galanin also inhibited LTP in hippocampal slices prepared from …
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Investigations into the physiological actions of nitric oxide in the nervous systems of the ring dove and the rat
… ganglion and enhance synaptic transmission when extracellularly recording the compound action potential (CAP), intracellular recording did not reveal such clear responses. This difference was attributed to the fact that a subpopulation of the principal neurones receives a NO input. These findings …
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Optimizing Multi-Well Micro-Electrode Array (MW-MEA) Design to Study the Electrophysiology of Neurons
… was to optimize the MEA design to improve the recording efficiency from a group of cells in an area to have a better understanding of what is happening over a larger network. This study included three phases: investigating the effectiveness of a preliminary version of multi-well MEA design with …
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Somatosensory processing by rat medial pontomedullary reticular formation neurones : responses to innocuous and noxious thermal and mechanical stimuli
… at 38 ± 0,5°C. Standard stereotactic and extracellular recording techniques were employed. PMRF giant neurones were identified by their stereotactic location, large, stable spike amplitudes of long duration, responses to cutaneous mechanical stimuli and receptive field properties, and …
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Advancing three-dimensional electrophysiology: Development and evaluation of versatile platform for tailored 3D microelectrode array fabrication
… conventional standard for decades, enabling the extracellular recording and stimulation of cultured neuronal cells and tissue slices. However, the effectiveness of planar MEAs diminishes when stimulating or recording from 3D in vitro neuronal cultures or brain slices owing to rapid data …
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