Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"extracellular matrix stiffness"”.
-
Influence of Extracellular Matrix Stiffness and Topography on Neuronal Cell Behavior and Neurite Outgrowth
… attempts to improve this by modifying the stiffness and topography of the extracellular matrix (ECM). However, the limitations of in vitro experiments make it difficult to control the individual factors influencing neuronal cell growth. A computational model can be used to decouple …
-
Extracellular matrix stiffness and geometry: The impact on static and dynamic cellular systems in vitro and the treatment of tissue ischemia
… how main cell functions can be controlled by the matrix mechanical properties, with a goal to emulate physiological processes in vitro and potentiate stem cell treatments with appropriate bio-matrix design. First, I describe a method to promote advanced cardiomyogenic and endothelial …
-
Biophysical and gene expression change in living cells by force-induced mechanotransduction
… forces transmitted through different natural extracellular matrix proteins or cell-cell adhesion molecules such as fibronectin, laminin or E-cadherin, have different effects on cell spreading, cell stiffness, Oct3/4 gene expression, and cell proliferation rate. Surprisingly, it was also …
-
Controlling Curvature and Stiffness in Fibrous Environments Uncovers Force-Driven Processes and Phenotypes
… Overall, we investigated cancer biology through stiffness gradients, geometric influence through biophysics on myoblasts, and immune cell migration forces as a strong indicator of cell behavior.